Nitroxoline
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| Systematic (IUPAC) name | |
| 5-nitroquinolin-8-ol | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 4008-48-4  |
| ATC code | J01XX07 |
| PubChem | CID 19910 |
| DrugBank | DB01422 |
| ChemSpider | 18756 |
| UNII | A8M33244M6 |
| KEGG | D07245 |
| ChEMBL | CHEMBL1454910  |
| Chemical data | |
| Formula | C9H6N2O3 |
| Mol. mass | 190.156 g/mol |
| SMILES | eMolecules & PubChem |
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Nitroxoline is an antibiotic.[1]
It was recently discovered that nitroxoline has antiangiogenic properties, which could make it useful as an anti-cancer drug. [2]
[edit] References
- ^ Pelletier C, Prognon P, Bourlioux P (1995). "Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains". Antimicrob. Agents Chemother. 39 (3): 707–13. PMC 162609. PMID 7793877. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=7793877.
- ^ Joong Sup Shim, Yoshiyuki Matsui, Shridhar Bhat, Benjamin A. Nacev, Jing Xu, Hyo-eun C. Bhang, Surajit Dhara, Kee Chung Han, Curtis R. Chong, Martin G. Pomper, Alan So Jun O. Liu (2010). "Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer". J Natl Cancer Inst. 102 (24): 1855–1873. doi:10.1093/jnci/djq457. PMC 3001967. PMID 21088277. http://jnci.oxfordjournals.org/content/102/24/1855.full.
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