The Oklahoma Baptist Bison are composed of 19 teams representing Oklahoma Baptist University in intercollegiate athletics, including men and women's basketball, cross country, golf, soccer, swimming & diving, tennis, and track and field. Men's sports include baseball and football. Women's sports include lacrosse, softball, and volleyball. The Bison compete in the NAIA and are members of the Sooner Athletic Conference.
As of July 11, 2014, the NCAA Division II Membership Committee recommended the membership application for Oklahoma Baptist to set up the move from the NAIA to NCAA Division II, primarily joining the Great American Conference, effectively the 2015–16 season.
OBU has won NAIA championships in men's swimming and diving (2012 and 2013) and women's swimming and diving (2013).
On March 9, 2012, swim team member Ivan Maciuniak, age 22, drowned in the pool. A native of Las Palmas, Canary Islands, Spain, Maciuniak had joined his brother, Mateo, at OBU in January 2012. The Maciuniak brothers were on the four-man 400-meter relay team which won the final event of the meet to claim the national championship in OBU’s first year of intercollegiate swimming.