Paolo Macchiarini, M.D., Ph.D. was head and chairman of the Hospital Clínic (Barcelona Metro) de Barcelona, University of Barcelona in Barcelona, Spain, as well as professor of surgery at the University of Barcelona in Spain, and at the Hannover Medical School in Hannover, Germany. Presently he is Professor of Regenerative Medicine at Karolinska Institutet in Stockholm (Sweden), as well as director of the ACTREM (Advanced Center for Regenerative Medicine) in the same Institute. He is also Honorary Professor at London University College.
Macchiarini completed his residency in thoracic surgery at the University of Pisa in Pisa, Italy. Macchiarini completed a fellowship in the department of thoracic surgery at the University of Alabama at Birmingham in Birmingham, Alabama, with an additional fellowship completed in the department of thoracic and vascular surgery and heart-lung transplantation, Hôpital Marie-Lannelongue, Paris-Sud University, Le Plessis Robinson, France.
Macchiarini's interests include extended surgery for lung, esophageal, and mediastinal tumors; adult and pediatric tracheal surgery; lung and heart-lung transplantation; pulmonary endarterectomy; (bio)artificial lung; and experimental research, education, training.
Macchiarini has contributed to the field of Regenerative medicine when in 2008 he performed the first Adult stem cell grown trachea transplant. The first successful operation on a child followed in March 2010. On June 9, 2011 at Karolinska University Hospital in Stockholm, Sweden, doctors including Paolo Macchiarini implanted a synthetic windpipe into a 36-year-old man with late-stage tracheal cancer. The synthetic windpipe was made at University College London, by Professor Alexander Seifalian.
In July 2011, Macchiarini came to the United States and interviewed Rachel Phillips, a former Royal Ballet of London dancer, to assess the potential of using this procedure to help with her severe case of tracheobronchomalasia brought on by ElhersDanlos Syndrome complications. After reviewing her case, Mrs. Phillips was approved for the treatment and will likely be the first American recipient of the procedure.
The second patient to receive a synthetic windpipe was another cancer patient from Baltimore, who was operated on in Stockholm in November 2011 and went home in January 2011, "in a good shape" as reported prof. Macchiarini. Among the patients candidate to surgery there is also a Korean baby, Hannah Warren, who was born (in August 2010) with an underdeveloped trachea and survived for 2 months thanks to a tube inserted in a bronchus through the oesophagus and an aesophagus-broncus fistula. On July 6, 2013, Hannah Warren died from complications with her surgery.
Christopher Lyles (second trachea transplant), Macchiarini's synthetic-trachea cancer patient from Baltimore, died in early March 2012.
With the current success of regenerative medicine via stem cell research and continued success of treating patients diagnosed with non-treatable diseases through traditional medicine the non-profit foundation "CHANGE A LIFE - REGENERATE A LIFE" was founded in February 2012 by Paolo Macchiarini, Alex Roberts and Luis Coronas. The main objective is to raise awareness of RM, (regenerative medicine) giving patients and their families hope of a better quality of life including life itself. The raising of funds will also help to further the research and development of RM via stem cells, including helping patients who are met with financial difficulties for such procedures where their medical insurance companies will not cover the expenses.
In June 2012 Macchiarini transplanted a syntetic trachea and cricoid (a part of the larynx) in two patients at Krasnodar University in Russia.
In April 2013, at the Children's Hospital of Illinois at OSF Saint Francis Medical Center (in a 9-hour procedure working with local pediatric surgeon Mark Holterman- the parents, a Newfoundland, Canada man and a South Korean woman living in her country), he gave a 3-inch long, bone marrow stem cell-cultured artificial trachea, or windpipe, to 2-year-old Hannah Warren, who had until then spent all her life in the Seoul National University Hospital in Seoul, South Korea, and was initially not expected to survive. She was the youngest patient yet to undergo that procedure, and only about 50,000 people in the world have her condition. Hannah died a few months later on July 6, 2013.
- ReachMD - Paolo Macchiarini, MD
- Paolo Macchiarini: CTSNET Member Homepage
- Adult stem cell breakthrough University of Bristol, November 19, 2008
- Adult Stem Cell Breakthrough: First Tissue-Engineered Trachea Successfully Transplanted Science Daily, November 18, 2008
- Doctors give woman a new windpipe, using her own stem cells New York Daily News/AP, November 19, 2008
- Windpipe transplant success in UK child BBC News, March 19, 2010
- Macchiarini P (2011). "Bioartificial tracheobronchial transplantation. Interview with Paolo Macchiarini". REGENERATIVE MEDICINE 6 (6 Supplement): 14–15. doi:10.2217/rme.11.81. PMID 21999257.
- "Youngest Girl Given Bio-Engineered Windpipe Dies". nbcbayarea.com. NBCUniversal Media. Retrieved 2 October 2013. "A nearly 3-year-old toddler who was the youngest person ever to receive a bio-engineered organ died Saturday in Illinois, surgeons involved in her treatment said."
- Paolo Macchiarini, M.D., Ph.D. profile from the Cardiothoracic Surgery Network
- Paolo Macchiarini articles in The Lancet
- Regeneration of airways and lung