Protoporphyrinogen IX

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Protoporphyrinogen IX

Identifiers
CAS number	7412-77-3
PubChem	1039
MeSH	protoporphyrinogen
Properties
Molecular formula	C₃₄H₅₂N₄O₄
Molar mass	580.801 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Protoporphyrinogen IX is a precursor for protoporphyrin IX. See Porphyrins for the pathway and more information.

Heme synthesis - note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)

[edit] See also

Protoporphyrinogen oxidase

Types of tetrapyrroles

Bilanes
(Linear)

Bilirubin · Biliverdin · Stercobilinogen · Stercobilin · Urobilinogen · Urobilin

Phytochromobilin

Phycobilins	Phycoerythrobilin · Phycocyanobilin · Phycourobilin · Phycoviolobilin

Methylcobalamin · Adenosylcobalamin · Cyanocobalamin

Protoporphyrins	Protoporphyrin IX · Heme (b, c, a, o) · Zinc protoporphyrin · Magnesium protoporphyrin

Phytoporphyrins	Chlorophyll c1 · Chlorophyll c2 · Protochlorophyllide

Reduced
porphyrins

Porphyrinogens	Uroporphyrinogen (I, III) · Coproporphyrinogen (I, III) · Protoporphyrinogen IX

Chlorins	Chlorophyllide (a, b) · Chlorophyll (a, b) · Phaeophytin (a, b) · Bacteriochlorophyll c

Bacteriochlorins	Bacteriochlorophyll a

Isobacteriochlorins	Siroheme · Sirohydrochlorin

Corphins	Cofactor F430

biochemical families: proteins (amino acids/intermediates) · nucleic acids (constituents/intermediates) · carbohydrates (glycoproteins, alcohols, glycosides)
lipids (fatty acids/intermediates, phospholipids, steroids, sphingolipids, eicosanoids) · tetrapyrroles/intermediates

Heme metabolic intermediates

Porphyrin biosynthesis

early mitochondrial: D-Aminolevulinic acid

cytosolic: Porphobilinogen · Hydroxymethylbilane · Uroporphyrinogen III · Coproporphyrinogen III

late mitochondrial: Protoporphyrinogen IX · Protoporphyrin IX

Heme degradation
and excretion

Breakdown of heme	spleen: Heme → Biliverdin → Bilirubin blood: Bilirubin+Albumin liver: Bilirubin diglucuronide

Intestine, excretion in feces	Stercobilinogen · Stercobilin · Urobilinogen

Kidney, excretion in urine	Urobilin

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

biochemical families: proteins (amino acids/intermediates) · nucleic acids (constituents/intermediates) · carbohydrates (glycoproteins, alcohols, glycosides)
lipids (fatty acids/intermediates, phospholipids, steroids, sphingolipids, eicosanoids) · tetrapyrroles/intermediates

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