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Richard Lewontin

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Richard Lewontin
Born
Richard Charles Lewontin

(1929-03-29)March 29, 1929
New York City, New York, U.S.
DiedJuly 4, 2021(2021-07-04) (aged 92)
Alma materHarvard University (BS)
Columbia University (MS, PhD)
Known forEvolutionary biology
Population genetics
AwardsSewall Wright Award (1994), Crafoord Prize (2015), Thomas Hunt Morgan Medal (2017)
Scientific career
FieldsGenetics
Evolutionary biology
Population genetics
InstitutionsHarvard University
North Carolina State University
University of Rochester
University of Chicago
Columbia University
ThesisThe Effects of Population Density and Composition on Viability in Drosophila melanogaster (1955)
Doctoral advisorTheodosius Dobzhansky[1]
Doctoral studentsAdriana Briscoe
Jerry Coyne
Joseph Felsenstein
Martin Kreitman[2]
Russell Lande

Richard Charles Lewontin (March 29, 1929 – July 4, 2021[3]) was an American evolutionary biologist, mathematician, geneticist, and social commentator. A leader in developing the mathematical basis of population genetics and evolutionary theory, he pioneered the application of techniques from molecular biology, such as gel electrophoresis, to questions of genetic variation and evolution.

In a pair of seminal 1966 papers co-authored with J. L. Hubby in the journal Genetics,[4][5] Lewontin helped set the stage for the modern field of molecular evolution. In 1979 he and Stephen Jay Gould introduced the term "spandrel" into evolutionary theory. From 1973 to 1998, he held an endowed chair in zoology and biology at Harvard University, and from 2003 until his death in 2021 he was a research professor there.

Lewontin opposed genetic determinism.[6]

Early life and education

Lewontin was born in New York City, to parents descended from late 19th-century Ashkenazi Jewish immigrants. His father was a broker of textiles, and his mother a homemaker.[7] He attended Forest Hills High School and the École Libre des Hautes Études in New York. In 1951 he graduated from Harvard College with a BS degree in biology. In 1952, Lewontin received an MS degree in mathematical statistics, followed by a PhD degree in zoology in 1954,[8] both from Columbia University, where he was a student of Theodosius Dobzhansky.

He held faculty positions at North Carolina State University, the University of Rochester, and the University of Chicago. In 1973 Lewontin was appointed as Alexander Agassiz Professor of Zoology and Professor of Biology at Harvard University, holding the position until 1998.

Career

Work in population genetics

Lewontin worked in both theoretical and experimental population genetics. A hallmark of his work was an interest in new technology. He was the first person to do a computer simulation of the behavior of a single gene locus (previous simulation work having been of models with multiple loci).[citation needed] In 1960, he and Ken-Ichi Kojima were the first population geneticists to give the equations for change of haplotype frequencies with interacting natural selection at two loci.[9] This set off a wave of theoretical work on two-locus selection in the 1960s and 1970s. Their paper gave a theoretical derivation of the equilibria expected, and also investigated the dynamics of the model by computer iteration. Lewontin later introduced the D' measure of linkage disequilibrium.[10] (He also introduced the term "linkage disequilibrium", about which many population geneticists have been unenthusiastic.[11])

In 1966, he and J. L. Hubby published a paper that revolutionized population genetics.[4] They used protein gel electrophoresis to survey dozens of loci in the fruit fly Drosophila pseudoobscura, and reported that a large fraction of the loci were polymorphic, and that at the average locus there was about a 15% chance that the individual was heterozygous. (Harry Harris reported similar results for humans at about the same time.)[12] Previous work with gel electrophoresis had been reports of variation in single loci and did not give any sense of how common variation was.

Lewontin and Hubby's paper also discussed the possible explanation of the high levels of variability by either balancing selection or neutral mutation. Although they did not commit themselves to advocating neutrality, this was the first clear statement of the neutral theory for levels of variability within species. Lewontin and Hubby's paper had great impact—the discovery of high levels of molecular variability gave population geneticists ample material to work on, and gave them access to variation at single loci. The possible theoretical explanations of this rampant polymorphism became the focus of most population genetics work thereafter. Martin Kreitman was later to do a pioneering survey of population-level variability in DNA sequences while a Ph.D. student in Lewontin's lab.[13]

Work on human genetic diversity

File:Lewontin globe.png
Richard Lewontin surrounded by wife, his main influences, his mentors and friends. Three at the top are: James F. Crow, Steven Rose, and Marcus Feldman. Five right above Lewontin: Montgomery Slatkin, Stephen J Gould, Leon Kamin, Mary Jane Lewontin, John L Hubby. Six arching below Lewontin: Friedrich Engels, Karl Marx, G.W.F. Hegel, Charles R. Darwin, Richard Levins, Theodosius Dobzhansky.

In a landmark paper, published in 1972, Lewontin identified that most of the variation (80–85%) within human populations is found within local geographic groups, and differences attributable to traditional "race" groups are a minor part of human genetic variability (1–15%).[14] In a 2003 paper, A. W. F. Edwards criticized Lewontin's conclusion that race is an invalid taxonomic construct, terming it Lewontin's fallacy. He argued that the probability of racial misclassification of an individual based on variation in a single genetic locus is approximately 30% and the misclassification probability becomes close to zero if enough loci are studied.[15] Edwards' criticism in turn garnered its own criticism from biologists such as Jonathan Marks, who argued that "the point of the theory of race was to discover large clusters of people that are principally homogeneous within and heterogeneous between, contrasting groups. Lewontin's analysis shows that such groups do not exist in the human species, and Edwards' critique does not contradict that interpretation."[16][17][18]

Affiliations

As of 2003, Lewontin was the Alexander Agassiz Research Professor at Harvard. He has worked with and had great influence on many philosophers of biology, including William C. Wimsatt, Elliott Sober, Philip Kitcher, Elisabeth Lloyd, Peter Godfrey-Smith, Sahotra Sarkar, and Robert Brandon, often inviting them to work in his lab.

Since 2013, Lewontin has been listed on the Advisory Council of the National Center for Science Education.[19]

Debates within mainstream evolutionary biology

In 1975, when E. O. Wilson's book Sociobiology proposed evolutionary explanations for human social behaviors, biologists including Lewontin, his Harvard colleagues Stephen Jay Gould and Ruth Hubbard responded negatively.[20]

Lewontin and Gould introduced the term spandrel to evolutionary biology, inspired by the architectural term "spandrel", in an influential 1979 paper, "The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme." "Spandrels" were described as features of an organism that exist as a necessary consequence of other (perhaps adaptive) features, but do not directly improve fitness (and thus are not necessarily adaptive).[21] The relative frequency of spandrels versus adaptations continues to stir controversy in evolutionary biology.

Lewontin was an early proponent of a hierarchy of levels of selection in his article, "The Units of Selection". He has been a major influence on philosophers of biology, notably William C. Wimsatt (who taught with Lewontin and Richard Levins at the University of Chicago), Robert Brandon and Elisabeth Lloyd (who studied with Lewontin as graduate students), Philip Kitcher, Elliott Sober, and Sahotra Sarkar. Lewontin briefly argued for the historical nature of biological causality in "Is Nature Probable or Capricious?".[22]

In "Organism and Environment" in Scientia, and in more popular form in the last chapter of Biology as Ideology, Lewontin argued that while traditional Darwinism has portrayed the organism as a passive recipient of environmental influences, a correct understanding should emphasize the organism as an active constructor of its own environment. Niches are not pre-formed, empty receptacles into which organisms are inserted, but are defined and created by organisms. The organism-environment relationship is reciprocal and dialectical. M. W. Feldman and others[23] have developed Lewontin's conception in more detailed models under the term niche construction.

In the adaptationist view of evolution, the organism is a function of both the organism and environment, while the environment is only a function of itself. The environment is seen as autonomous and unshaped by the organism. Lewontin instead believed in a constructivist view, in which the organism is a function of the organism and environment, with the environment being a function of the organism and environment as well. This means that the organism shapes the environment as the environment shapes the organism. The organism shapes the environment for future generations.[24]

Lewontin criticized traditional neo-Darwinian approaches to adaptation. In his article "Adaptation" in the Italian Enciclopedia Einaudi, and in a modified version for Scientific American, he emphasized the need to give an engineering characterization of adaptation separate from measurement of number of offspring, rather than simply assuming organs or organisms are at adaptive optima.[25] Lewontin said that his more general, technical criticism of adaptationism grew out of his recognition that the fallacies of sociobiology reflect fundamentally flawed assumptions of adaptiveness of all traits in much of the modern evolutionary synthesis.

Lewontin accused neo-Darwinists of telling Just-So Stories when they try to show how natural selection explains such novelties as long-necked giraffes.[26]

Sociobiology and evolutionary psychology

Along with others, such as Gould, Lewontin was a persistent critic of some themes in neo-Darwinism. Specifically, he criticized proponents of sociobiology and evolutionary psychology, such as Edward O. Wilson and Richard Dawkins, who attempt to explain animal behaviour and social structures in terms of evolutionary advantage or strategy. He and others criticize this approach when applied to humans, as he sees it as genetic determinism. In his writing, Lewontin suggests a more nuanced view of evolution is needed, which requires a more careful understanding of the context of the whole organism as well as the environment.[27]

Such concerns about what he viewed as the oversimplification of genetics led Lewontin to be a frequent participant in debates, and an active life as a public intellectual. He lectured widely to promote his views on evolutionary biology and science. In the book Not in Our Genes (co-authored with Steven Rose and Leon J. Kamin) and numerous articles, Lewontin questioned much of the claimed heritability of human behavioral traits, such as intelligence as measured by IQ tests.[citation needed]

Some academics have criticized him for rejecting sociobiology for non-scientific reasons. Edward Wilson (1995) suggested that Lewontin's political beliefs affected his scientific view. Others, such as Kitcher (1985), countered that Lewontin's criticisms of sociobiology are genuine scientific concerns about the discipline. He wrote that attacking Lewontin's motives amounts to an ad hominem argument.[citation needed] Lewontin at times identified himself as Marxist, and asserted that his philosophical views have bolstered his scientific work (Levins and Lewontin 1985).

Agribusiness

Lewontin has written on the economics of agribusiness. He has contended that hybrid corn was developed and propagated not because of its superior quality, but because it allowed agribusiness corporations to force farmers to buy new seed each year rather than plant seed produced by their previous crop of corn (Lewontin 1982). Lewontin testified in an unsuccessful suit in California challenging the state's financing of research to develop automatic tomato pickers. This favored the profits of agribusiness over the employment of farm workers (Lewontin 2000).

Personal life

As of mid-2015, Lewontin and his wife Mary Jane (Christianson) lived on a farm in Brattleboro, Vermont. They had four sons. He was an atheist.[28]

Lewontin died at his home in Cambridge, Massachusetts on July 4, 2021, at the age of 92.[3][29]

Recognition

Bibliography

Scholia has a profile for Richard Lewontin (Q659265).
  • Lewontin, R. C.; Kojima, K. (December 1960). "The Evolutionary Dynamics of Complex Polymorphisms". Evolution. 14 (4). Society for the Study of Evolution: 458–472. doi:10.2307/2405995. JSTOR 2405995.
  • Lewontin, R. C. (January 1966). "Is Nature Probable or Capricious?". BioScience. 16 (1, Logic in Biological Investigation). University of California Press: 25–27. doi:10.2307/1293548. JSTOR 1293548.
  • Lewontin, R. C. (1970). "The Units of Selection". Annual Review of Ecology and Systematics. 1: 1–18. doi:10.1146/annurev.es.01.110170.000245.
  • "The Apportionment of Human Diversity," Evolutionary Biology, vol. 6 (1972) pp. 391–398.
  • Lewontin, R. C. (1974). The Genetic Basis of Evolutionary Change. New York: Columbia University Press. ISBN 0-231-03392-3.
  • "Adattamento," Enciclopedia Einaudi, (1977) vol. 1, 198–214.
  • "Adaptation," Scientific American, vol. 239, (1978) 212–228.
  • Gould, S. J.; Lewontin, R. C. (1979). "The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme". Proceedings of the Royal Society B: Biological Sciences. 205 (1161): 581–98. Bibcode:1979RSPSB.205..581G. doi:10.1098/rspb.1979.0086. PMID 42062. S2CID 2129408.
  • Lewontin, R. C. (1982). Human diversity. New York: Scientific American Library. ISBN 0-7167-6013-4.
  • "The Organism as Subject and Object of Evolution," Scientia vol. 188 (1983) 65–82.
  • Not in Our Genes: Biology, Ideology and Human Nature (with Steven Rose and Leon J. Kamin) (1984) ISBN 0-394-72888-2.
  • The Dialectical Biologist (with Richard Levins), Harvard University Press (1985) ISBN 0-674-20283-X.
  • Biology as Ideology: The Doctrine of DNA (1991) ISBN 0-06-097519-9.
  • The Triple Helix: Gene, Organism, and Environment, Harvard University Press (2000) ISBN 0-674-00159-1.
  • It Ain't Necessarily So: The Dream of the Human Genome and Other Illusions, New York Review of Books (2000).
  • Biology Under The Influence: Dialectical Essays on the Coevolution of Nature and Society (with Richard Levins), (2007).
  • Agricultural research and the penetration of capital (1982) Science for the People 14 (1): 12–17
  • Lewontin, R.C. The maturing of capitalist agriculture: farmer as proletarian. P. 93–106 in F. Magdoff, J. B. Foster, and F. H. Buttel, Eds. 2000. Hungry for Profit: The Agribusiness Threat to Farmers, Food, and the Environment. Monthly Review Press, NY.

References

  1. ^ Richard Lewontin at the Mathematics Genealogy Project
  2. ^ Kreitman, Martin Edward (1983). Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster (PhD thesis). Harvard University. ProQuest 303271509.
  3. ^ a b Angier, Natalie (July 7, 2021). "Richard C. Lewontin, Eminent Geneticist With a Sharp Pen, Dies at 92". The New York Times. Retrieved July 8, 2021.
  4. ^ a b Lewontin, R. C.; Hubby, J. L. (1966). "A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura". Genetics. 54 (2): 595–609. doi:10.1093/genetics/54.2.595. PMC 1211186. PMID 5968643.
  5. ^ Hubby, J. L.; Lewontin, R. C. (1966). "A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura". Genetics. 54 (2): 577–594. doi:10.1093/genetics/54.2.577. PMC 1211185. PMID 5968642.
  6. ^ Peters, Ted (2003). Playing God? genetic determinism and human freedom (2nd ed.). New York: Routledge. pp. 29–31. ISBN 978-0-415-94249-2.
  7. ^ Langer, Emily (July 16, 2021). "Geneticist Warned Against 'Genomania'". Washington Post. Vol. 144, no. 223. p. B6. Retrieved July 17, 2021.
  8. ^ Lewontin, Richard Charles (2012). The Effects of Population Density and Composition on Viability in Drosophila melanogaster (PhD thesis). Columbia University. ProQuest 301991815.
  9. ^ Lewontin, R. C.; Kojima, Kenichi (1960). "The evolutionary dynamics of complex polymorphisms". Evolution 14: 458-472.
  10. ^ Lewontin, R. C. (1964). "The interaction of selection and linkage. I. General considerations; heterotic models". Genetics 49: 49-67.
  11. ^ Slatkin, Montgomery (June 2008). "Linkage disequilibrium — understanding the evolutionary past and mapping the medical future" (PDF). Nature Reviews Genetics. 9 (6): 477–485. doi:10.1038/nrg2361. PMC 5124487. PMID 18427557.
  12. ^ Harris, H. (1966). "Enzyme Polymorphisms in Man". Proceedings of the Royal Society B: Biological Sciences. 164 (995): 298–310. Bibcode:1966RSPSB.164..298H. doi:10.1098/rspb.1966.0032. PMID 4379519. S2CID 43582403.
  13. ^ Kreitman, M. (1983). "Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster". Nature. 304 (5925): 412–417. Bibcode:1983Natur.304..412K. doi:10.1038/304412a0. PMID 6410283. S2CID 4348580.
  14. ^ Lewontin, R (1972). "The Apportionment of Human Diversity". Evolutionary Biology. 6: 391–398. doi:10.1007/978-1-4684-9063-3_14. ISBN 978-1-4684-9065-7. S2CID 21095796.
  15. ^ Edwards, A. W. F. (2003). "Human genetic diversity: Lewontin's fallacy". BioEssays. 25 (8): 798–801. doi:10.1002/bies.10315. PMID 12879450.
  16. ^ Marks, Jonathan M. (2010). "Ten Facts about Human Variation". In Muehlenbein, M. P. (ed.). Human Evolutionary Biology. Cambridge University Press. p. 270. ISBN 9781139789004.
  17. ^ Kaplan, Jonathan Michael; Winther, Rasmus Grłnfeldt (2013). "Prisoners of Abstraction? The Theory and Measure of Genetic Variation, and the Very Concept of 'Race'" (PDF). Biological Theory. 7 (4): 401–412. doi:10.1007/s13752-012-0048-0. S2CID 52825769.
  18. ^ Jackson, John P; Depew, David J. (2017). Darwinism, Democracy, and Race American Anthropology and Evolutionary Biology in the Twentieth Century. Taylor & Francis. p. 223. ISBN 978-1351810777.
  19. ^ "Advisory Council". ncse.com. National Center for Science Education. Archived from the original on August 10, 2013. Retrieved October 30, 2018.
  20. ^ Elizabeth Allen et al., 1975, "Against 'Sociobiology'", The New York Review of Books, November 13, 1975
  21. ^ Gould SJ, Lewontin RC (1979). "The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme". Proc. R. Soc. Lond. B Biol. Sci. 205 (1161): 581–98. Bibcode:1979RSPSB.205..581G. doi:10.1098/rspb.1979.0086. PMID 42062. S2CID 2129408.
  22. ^ Lewontin RC (1966). "Is nature probable or capricious". BioScience. 16 (1): 25–27. doi:10.2307/1293548. JSTOR 1293548.
  23. ^ Niche Construction: The Neglected Process in Evolution Odling-Smee F. J., Laland K. N., Feldman M. W. Princeton University Press, 2003
  24. ^ Richard Levins and Richard Lewontin, The Dialectical Biologist, 1985
  25. ^ Lewontin, R. C. (1978). "Adaptation". Scientific American. 239 (3): 212–218, 220, 218 passim. Bibcode:1978SciAm.239c.212L. doi:10.1038/scientificamerican0978-212. PMID 705323.
  26. ^ "Science Contra Darwin", Newsweek, April 8, 1985, p.50
  27. ^ Lewontin, Richard; Leon Kamin; Steven Rose (1984). Not in Our Genes: Biology, Ideology, and Human Nature. Pantheon Books. ISBN 0-394-50817-3.
  28. ^ "The Wars Over Evolution" New York Review of Books October 20, 2005 "I, his student and scientific epigone, ingested my unwavering atheism..."
  29. ^ "Richard Lewontin: Pioneering evolutionary biologist dies aged 92". New Scientist. July 5, 2021. Retrieved July 5, 2021.
  30. ^ "Scientist as Activist". globetrotter.berkeley.edu. Institute of International Studies. Archived from the original on August 11, 2004. Retrieved October 31, 2018.
  31. ^ "Entry for Richard Lewinton for the National Academy of Sciences". United States National Academy of Sciences. Retrieved April 3, 2022.
  32. ^ "Genetics Society of America honors Richard Lewontin with 2017 Thomas Hunt Morgan Medal". eurekalert.org. Eurekalert. Archived from the original on March 24, 2017. Retrieved October 31, 2018.

Further reading

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