Marquette was born in Dallas, Texas, the son of Patricia Helen "Tisha" (née Market) and Jorge Luis "George" Rodriguez, a nuclear engineer. He is the youngest of the three Marquette brothers (himself, Chris and Eric), all of whom are active in entertainment. At age 9 he was accused of murder, though the charges were later dropped. His difficult upbringing was made him a target for bullies at his elementary school, John Jay. He made his acting debut on television on the ABCsoap operaAll My Children in 1994 playing Jamie Martin.