Nsimbi as he is efficiently known as in the football circles sign for Abafana Bes'thende in 2005 from Safa Second Division side Uthukela. He played well for Arrows and contributed to the club's first major silverware which was the MTN8 in 2009. He attracted many clubs and eventually signed for Orlando Pirates in 2011.
Sangweni signed with Orlando Pirates at the beginning of the 2011/12 season. Hailed as one of the best signings of the season due to his defensive abilities. He was a regular starter for Bafana Bafana while playing for Golden Arrows. Siyabonga became a regular at Orlando Pirates and went on to have 28 league appearances in his first season at Pirates. Due to him being very instrumental in the Pirates treble winning of the season, he was nominated as a Footballer of the Season which eventually went to the League's leading goalscorer, Siyabonga Nomvethe of Swallows. He has enjoyed much game-time along Lucky Lekgwati and Rooi Mahamutsa. He got an injury that kept him to almost all the 2013/14 season.