From the top twelve placed CAF member associations, the winner of the domestic cup competition and the third placed club in the domestic league of the considered associations, are eligible to participate in the CAF Confederation Cup, while only domestic cup winners from member associations ranked from 13 till 55 are eligible to participate in the competition.
The matches of the Preliminary, the 1/16th, the 1/8th rounds are played according to the knock-out system with ties broken via the Away goals rule. The eight teams eliminated from the 1/8th finals of the CAF Champions League will automatically qualify to play the additional 1/8th finals round of the CAF Confederation Cup.
The eight teams which will qualify for the group matches from the additional 1/8th finals will be divided in two groups of four each. Each team shall play six matches against the other three opponents one match home and one match away and points granted upon the 3-1-0 system.
The two group winners shall meet in the final which shall be played in two matches, home and away. The team scoring the highest aggregate number of goals in the two matches will be declared winner.
In case of equality in the number of goals scored during the two matches, the team scoring the greatest number of away goals will be declared winner. If the number of goals scored on the away matches is equal, kicks from the penalty mark will be taken.
The winning team of the CAF Confederation Cup will take the engagement of playing the CAF Super Cup against the champion of the CAF Champions League. The match will be played in the following year to that of the concerned competition, in one match, on the CAF Champions League champion's venue.
The competition was founded by the CAF in 2004 by merging both the African Cup Winners' Cup and the CAF Cup in a single competition based upon the European model of the UEFA Cup which was also the adopted model while creating the CAF Cup previously in 1992.