Talk:Gonadotropin-releasing hormone

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Additional site[edit]

This article identifies a second locus of the gene for GnRH on chromosome 20. --David Iberri (talk) 05:14, 28 January 2006 (UTC)

Template conflict[edit]

The {{protein}} template or one of the templates used inside it seems to have a conflict with the reference template {{ref}}. --JWSchmidt 22:12, 13 June 2006 (UTC)

Converting the references with this converter fixed the problem. --JWSchmidt 13:07, 14 June 2006 (UTC)

GnRH in other organs[edit]

Perhaps not yet fully understood, but I would argue against the assertion that GnRH activity outside the CNS is "poorly understood". Some fascinating articles out of UBC in Vancouver, Canada suggest a clear role for GnRH I and II in the differential regulation of matrix metalloproteinase expression (MMP-2, MMP-9) as well as that of TIMP-1 in the placenta. GnRH appears to be an essential regulator for the invasion of the endometrium by cytotrophoblast cells of the blastocyst. (see this article Chou, C.-S. et al. J Clin Endocrinol Metab 2003;88:4781-4790) --|T 15:36, 11 December 2006 (UTC)

"While GNRH has been synthesized and become available..."

Would you include where it is available? I read in a document that it isn't available in the US, but the document isn't recent. —Preceding unsigned comment added by Fairlind (talkcontribs) 03:44, 30 March 2009 (UTC)

^Not sure what you mean, GnRH agonists are widely available. That sentence could sound better though.

In regards to the placental stuff, there's also evidence for GnRH induced CXC chemokine expression in placental trophoblasts, affecting lymphocyte recruitment (see and original article by Babwah et al). But to be honest the whole section needs a re-write. GnRH is important for cardiac development in zebrafish for example, but then there's no mention of other forms of GnRH (GnRHII, GnRHIII), just a focus on mammalian GnRHI. So a whole lot of work to be done.Numb3rz (talk) 19:16, 28 January 2010 (UTC)

Link between GnRH and Testosterone Levels[edit] —Preceding unsigned comment added by (talk) 16:53, 31 July 2009 (UTC)

Science in Action section[edit]

The Science in Action section should be deleted or moved to the Growth hormone releasing hormone article. Bruno Latours book refers to GHRH (also known as GRF) and not GnRH. This type of confusion is exactly why Schally himself prefers to use the name LHRH. (talk) 13:00, 5 October 2009 (UTC) Anon

I went ahead and deleted it. The sentence "as Schally initially called it" is plain wrong to the point of irritation. (talk) 13:11, 5 October 2009 (UTC) Anon

Anti-aging effects[edit]

'When the researchers injected GnRH into the hypothalamuses of mice, it promoted neuron generation and decelerated aging. The team gave daily GnRH injections to old mice over an extended period, finding that the treatment slowed cognitive decline due to aging.' — Preceding unsigned comment added by (talk) 05:59, 28 July 2013 (UTC)

Medical uses[edit]

@Doc James:. Since the order of sections of WP:MCBMOS and WP:MEDMOS conflict, I was first going to propose splitting this article into one focusing on the gene/protein and a second one of medical uses (similar to the split between insulin and insulin therapy). However it appears that the human medical use of natural GnRH has been discontinued (see Factrel and Cystorelin) and superseded by synthetic GnRH agonists. Natural GnRH is still used for veterinary use. Hence I propose to add a hat note to this article

This page is about the GnRH protein. For medical uses of GnRH, see GnRH agonists.

and to update the medical uses section of this article to make clear that this natural GnRH is no longer prescribed to humans and to include

Is this OK? Boghog (talk) 06:18, 5 March 2015 (UTC)

Thanks Bog. Sounds good. We need to figure out how to separate biochemicals from pharmaceuticals more effectively. This confusion occurs in a number of articles including Botox
Maybe separated into one tagged by (medicine) and the other with ? This is needed for epinephrine, norepinephrine etc. Doc James (talk · contribs · email) 19:06, 5 March 2015 (UTC)
Thanks Doc. I think this needs to be considered on a case by case basis. If the International Nonproprietary Name (INN) is distinct from scientific name (e.g., ciclosporin vs. cyclosporine), no disambiguation is necessary. Botox is a special case as an INN was never issued and the Botox trade name effectively became the generic name (similar to Adderall). In this case, we could split the articles between Botulinum toxin containing {{infobox enzyme}} and Botox containing {{infobox drug}}. If the INN and scientific name are identical, then I agree we need to disambiguate the two. If the drug vs. protein/biochemical subjects are unequal in prominence (see determining a primary topic), disambiguating the article that is less prominent would be appropriate. If the two articles are of equal prominence, the disambiguating both would be appropriate. Possible disambiguations included "(gene)" after gene/protein article name and "therapy" after drug article name. Boghog (talk) 21:42, 5 March 2015 (UTC)