Talk:Gonadotropin-releasing hormone

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Additional site[edit]

This article identifies a second locus of the gene for GnRH on chromosome 20. --David Iberri (talk) 05:14, 28 January 2006 (UTC)

Template conflict[edit]

The {{protein}} template or one of the templates used inside it seems to have a conflict with the reference template {{ref}}. --JWSchmidt 22:12, 13 June 2006 (UTC)

Converting the references with this converter fixed the problem. --JWSchmidt 13:07, 14 June 2006 (UTC)

GnRH in other organs[edit]

Perhaps not yet fully understood, but I would argue against the assertion that GnRH activity outside the CNS is "poorly understood". Some fascinating articles out of UBC in Vancouver, Canada suggest a clear role for GnRH I and II in the differential regulation of matrix metalloproteinase expression (MMP-2, MMP-9) as well as that of TIMP-1 in the placenta. GnRH appears to be an essential regulator for the invasion of the endometrium by cytotrophoblast cells of the blastocyst. (see this article Chou, C.-S. et al. J Clin Endocrinol Metab 2003;88:4781-4790) -- JE.at.UWOU|T 15:36, 11 December 2006 (UTC)

"While GNRH has been synthesized and become available..."

Would you include where it is available? I read in a document that it isn't available in the US, but the document isn't recent. —Preceding unsigned comment added by Fairlind (talkcontribs) 03:44, 30 March 2009 (UTC)

^Not sure what you mean, GnRH agonists are widely available. That sentence could sound better though.

In regards to the placental stuff, there's also evidence for GnRH induced CXC chemokine expression in placental trophoblasts, affecting lymphocyte recruitment (see http://ajpcell.physiology.org/cgi/pdf_extract/297/1/C4 and original article by Babwah et al). But to be honest the whole section needs a re-write. GnRH is important for cardiac development in zebrafish for example, but then there's no mention of other forms of GnRH (GnRHII, GnRHIII), just a focus on mammalian GnRHI. So a whole lot of work to be done.Numb3rz (talk) 19:16, 28 January 2010 (UTC)

Link between GnRH and Testosterone Levels[edit]

http://linkinghub.elsevier.com/retrieve/pii/0093691X9500116P —Preceding unsigned comment added by 142.161.147.193 (talk) 16:53, 31 July 2009 (UTC)

Science in Action section[edit]

The Science in Action section should be deleted or moved to the Growth hormone releasing hormone article. Bruno Latours book refers to GHRH (also known as GRF) and not GnRH. This type of confusion is exactly why Schally himself prefers to use the name LHRH. 137.222.116.87 (talk) 13:00, 5 October 2009 (UTC) Anon

I went ahead and deleted it. The sentence "as Schally initially called it" is plain wrong to the point of irritation. 137.222.116.87 (talk) 13:11, 5 October 2009 (UTC) Anon

Anti-aging effects[edit]

'When the researchers injected GnRH into the hypothalamuses of mice, it promoted neuron generation and decelerated aging. The team gave daily GnRH injections to old mice over an extended period, finding that the treatment slowed cognitive decline due to aging.'

http://news.yahoo.com/brain-region-found-control-aging-191717771.html — Preceding unsigned comment added by 72.130.168.139 (talk) 05:59, 28 July 2013 (UTC)