An agoraphobic man falls ill and refuses to leave his home to be treated at the hospital. House and the team go to his home to figure out what might be causing his seizures. Cameron takes charge of the case as she had treated the patient in the past and she and the team figure out ways to treat him at his home. However, with Cameron's feelings for people who are sick, she does not end up giving the man the best diagnosis possible, leaving House and his team simple tools to diagnose with. The patient’s condition worsens and it becomes difficult to treat him at his home, therefore House and the team plan to get the man into the hospital for surgery without causing any problems. Cameron and Chase attempt to work through issues in their relationship, and House deals with an annoying itch he cannot seem to scratch, with Wilson making his own analogies about the problem. The final diagnosis is lead poisoning from bullet fragments from a seven year old shooting that stayed in his system.
House removes the bullet fragments, curing the patient of his seizures but he remains agoraphobic. The scene cuts to Taub and his wife making up, Chase and Cameron smiling after getting through their issues, House approaching Cuddy's doorstep, and the patient attempting to overcome his agoraphobia. Right as he is about to knock on Cuddy's door, House hesitates, looking at her through the window for a long time. Then he turns around and walks away as the video and music fade away. At the same time, the patient overcomes his fear and leaves the house.