Clifford Adams based UseModWiki on the code of AtisWiki by Marcus Denker. AtisWiki was based on CvWiki by Peter Merel. CvWiki was the first GNU-licensed wiki based on WikiBase, the wiki engine of the original WikiWikiWeb by Ward Cunningham.
The first installation of UseModWiki was Adams's usemod.com wiki, the basis of the Usenet Moderation Project (Usemod) which had been running on AtisWiki since October 11, 1999. The second wiki to use UseModWiki, the MeatballWiki created by Adams and Sunir Shah dedicated to online communities, was installed on the usemod.com Web site on April 24, 2000.
From January 15, 2001 until early 2002, UseModWiki was also used to run Wikipedia. All language instances of Wikipedia have since been moved over to MediaWiki.
UseMod was also used by Peter Harrison, the leader of the Festiniog Railway Heritage Group, to run its wiki, which had no name and was referred to as "FestWiki". In 2006, Harrison heavily modified a copy of UseMod 1.0 to run the site. The modified version was also called FestWiki, and bore a similar appearance to the MediaWiki of the time. The site used FestWiki until 2010, when it was migrated to MediaWiki itself.