Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 22:00, 9 November 2007 (UTC)[edit]
Proteins without matches (20)[edit]
Proteins with a High Potential Match (5)[edit]
Created (6)[edit]
Manual Inspection (Page not found) (19)[edit]
Protein Status Grid - Date: 22:00, 9 November 2007 (UTC)[edit]
Vebose Log - Date: 22:00, 9 November 2007 (UTC)[edit]
- INFO: Beginning work on AP2A1... {November 9, 2007 1:26:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AP2A1 image.jpg {November 9, 2007 1:26:47 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:27:03 PM PST}
- CREATED: Created new protein page: AP2A1 {November 9, 2007 1:27:11 PM PST}
- INFO: Beginning work on CADM1... {November 9, 2007 1:49:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:51:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell adhesion molecule 1
| HGNCid = 5951
| Symbol = CADM1
| AltSymbols =; BL2; DKFZp686F1789; IGSF4; IGSF4A; MGC149785; MGC51880; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; synCAM1
| OMIM = 605686
| ECnumber =
| Homologene = 8641
| MGIid = 1889272
| GeneAtlas_image1 = PBB_GE_CADM1_209030_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CADM1_209032_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0001913 |text = T cell mediated cytotoxicity}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007157 |text = heterophilic cell adhesion}} {{GNF_GO|id=GO:0008037 |text = cell recognition}} {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}} {{GNF_GO|id=GO:0042271 |text = susceptibility to natural killer cell mediated cytotoxicity}} {{GNF_GO|id=GO:0050715 |text = positive regulation of cytokine secretion}} {{GNF_GO|id=GO:0050798 |text = activated T cell proliferation}} {{GNF_GO|id=GO:0051606 |text = detection of stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23705
| Hs_Ensembl = ENSG00000182985
| Hs_RefseqProtein = NP_055148
| Hs_RefseqmRNA = NM_014333
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 114552404
| Hs_GenLoc_end = 114880322
| Hs_Uniprot =
| Mm_EntrezGene = 54725
| Mm_Ensembl = ENSMUSG00000032076
| Mm_RefseqmRNA = NM_001025600
| Mm_RefseqProtein = NP_001020771
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 47281368
| Mm_GenLoc_end = 47601384
| Mm_Uniprot =
}}
}}
'''Cell adhesion molecule 1''', also known as '''CADM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Watabe K, Ito A, Koma YI, Kitamura Y |title=IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. |journal=Histol. Histopathol. |volume=18 |issue= 4 |pages= 1321-9 |year= 2004 |pmid= 12973698 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD1A... {November 9, 2007 1:29:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD1A image.jpg {November 9, 2007 1:29:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:30:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1onq.
| PDB = {{PDB2|1onq}}, {{PDB2|1xz0}}
| Name = CD1a molecule
| HGNCid = 1634
| Symbol = CD1A
| AltSymbols =; CD1; FCB6; HTA1; R4; T6
| OMIM = 188370
| ECnumber =
| Homologene = 74408
| MGIid =
| GeneAtlas_image1 = PBB_GE_CD1A_210325_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 909
| Hs_Ensembl = ENSG00000158477
| Hs_RefseqProtein = NP_001754
| Hs_RefseqmRNA = NM_001763
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 156490551
| Hs_GenLoc_end = 156494683
| Hs_Uniprot = P06126
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD1a molecule''', also known as '''CD1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.<ref>{{cite web | title = Entrez Gene: CD1A CD1a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=909| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82-8 |year= 1996 |pmid= 8729450 |doi= }}
*{{cite journal | author=Park SH, Bendelac A |title=CD1-restricted T-cell responses and microbial infection. |journal=Nature |volume=406 |issue= 6797 |pages= 788-92 |year= 2000 |pmid= 10963609 |doi= 10.1038/35021233 }}
*{{cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817-90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608 }}
*{{cite journal | author=Coventry B, Heinzel S |title=CD1a in human cancers: a new role for an old molecule. |journal=Trends Immunol. |volume=25 |issue= 5 |pages= 242-8 |year= 2004 |pmid= 15099564 |doi= 10.1016/j.it.2004.03.002 }}
*{{cite journal | author=Moody DB, Zajonc DM, Wilson IA |title=Anatomy of CD1-lipid antigen complexes. |journal=Nat. Rev. Immunol. |volume=5 |issue= 5 |pages= 387-99 |year= 2005 |pmid= 15864273 |doi= 10.1038/nri1605 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
*{{cite journal | author=Quaranta MG, Mattioli B, Giordani L, Viora M |title=The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. |journal=FASEB J. |volume=20 |issue= 13 |pages= 2198-208 |year= 2006 |pmid= 17077296 |doi= 10.1096/fj.06-6260rev }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD22... {November 9, 2007 1:31:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:32:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD22 molecule
| HGNCid = 1643
| Symbol = CD22
| AltSymbols =; MGC130020; SIGLEC-2; SIGLEC2
| OMIM = 107266
| ECnumber =
| Homologene = 31052
| MGIid = 88322
| GeneAtlas_image1 = PBB_GE_CD22_38521_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD22_204581_at_tn.png
| GeneAtlas_image3 = PBB_GE_CD22_217422_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 933
| Hs_Ensembl = ENSG00000012124
| Hs_RefseqProtein = NP_001762
| Hs_RefseqmRNA = NM_001771
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 40511944
| Hs_GenLoc_end = 40530098
| Hs_Uniprot = P20273
| Mm_EntrezGene = 12483
| Mm_Ensembl = ENSMUSG00000030577
| Mm_RefseqmRNA = NM_001043317
| Mm_RefseqProtein = NP_001036782
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 30574589
| Mm_GenLoc_end = 30589029
| Mm_Uniprot = Q3T9T5
}}
}}
'''CD22 molecule''', also known as '''CD22''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tedder TF, Tuscano J, Sato S, Kehrl JH |title=CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. |journal=Annu. Rev. Immunol. |volume=15 |issue= |pages= 481-504 |year= 1997 |pmid= 9143697 |doi= 10.1146/annurev.immunol.15.1.481 }}
*{{cite journal | author=Blasioli J, Goodnow CC |title=Lyn/CD22/SHP-1 and their importance in autoimmunity. |journal=Curr. Dir. Autoimmun. |volume=5 |issue= |pages= 151-60 |year= 2002 |pmid= 11826756 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD5... {November 9, 2007 1:30:16 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 1:30:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:31:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ja4.
| PDB = {{PDB2|2ja4}}, {{PDB2|2ott}}
| Name = CD5 molecule
| HGNCid = 1685
| Symbol = CD5
| AltSymbols =; T1; LEU1
| OMIM = 153340
| ECnumber =
| Homologene = 7260
| MGIid = 88340
| GeneAtlas_image1 = PBB_GE_CD5_206485_at_tn.png
| Function = {{GNF_GO|id=GO:0005044 |text = scavenger receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}}
| Process = {{GNF_GO|id=GO:0008037 |text = cell recognition}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}} {{GNF_GO|id=GO:0031295 |text = T cell costimulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 921
| Hs_Ensembl = ENSG00000110448
| Hs_RefseqProtein = NP_055022
| Hs_RefseqmRNA = NM_014207
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 60626543
| Hs_GenLoc_end = 60651895
| Hs_Uniprot = P06127
| Mm_EntrezGene = 12507
| Mm_Ensembl = ENSMUSG00000024669
| Mm_RefseqmRNA = NM_007650
| Mm_RefseqProtein = NP_031676
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 10785188
| Mm_GenLoc_end = 10806019
| Mm_Uniprot = Q3UP78
}}
}}
'''CD5 molecule''', also known as '''CD5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berland R, Wortis HH |title=Origins and functions of B-1 cells with notes on the role of CD5. |journal=Annu. Rev. Immunol. |volume=20 |issue= |pages= 253-300 |year= 2002 |pmid= 11861604 |doi= 10.1146/annurev.immunol.20.100301.064833 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDC73... {November 9, 2007 1:51:02 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:51:24 PM PST}
- CREATED: Created new protein page: CDC73 {November 9, 2007 1:51:39 PM PST}
- INFO: Beginning work on COL6A1... {November 9, 2007 1:32:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:34:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type VI, alpha 1
| HGNCid = 2211
| Symbol = COL6A1
| AltSymbols =; OPLL
| OMIM = 120220
| ECnumber =
| Homologene = 1391
| MGIid = 88459
| GeneAtlas_image1 = PBB_GE_COL6A1_212091_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL6A1_212937_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL6A1_212938_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005589 |text = collagen type VI}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1291
| Hs_Ensembl = ENSG00000142156
| Hs_RefseqProtein = NP_001839
| Hs_RefseqmRNA = NM_001848
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 46226111
| Hs_GenLoc_end = 46248443
| Hs_Uniprot = P12109
| Mm_EntrezGene = 12833
| Mm_Ensembl = ENSMUSG00000001119
| Mm_RefseqmRNA = NM_009933
| Mm_RefseqProtein = NP_034063
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 76152508
| Mm_GenLoc_end = 76169760
| Mm_Uniprot = Q8C6Y0
}}
}}
'''Collagen, type VI, alpha 1''', also known as '''COL6A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.<ref>{{cite web | title = Entrez Gene: COL6A1 collagen, type VI, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1291| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bertini E, Pepe G |title=Collagen type VI and related disorders: Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. |journal=Eur. J. Paediatr. Neurol. |volume=6 |issue= 4 |pages= 193-8 |year= 2002 |pmid= 12374585 |doi= }}
*{{cite journal | author=Lampe AK, Bushby KM |title=Collagen VI related muscle disorders. |journal=J. Med. Genet. |volume=42 |issue= 9 |pages= 673-85 |year= 2006 |pmid= 16141002 |doi= 10.1136/jmg.2002.002311 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CPT2... {November 9, 2007 1:34:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:35:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carnitine palmitoyltransferase II
| HGNCid = 2330
| Symbol = CPT2
| AltSymbols =; CPT1; CPTASE
| OMIM = 600650
| ECnumber =
| Homologene = 77
| MGIid = 109176
| GeneAtlas_image1 = PBB_GE_CPT2_204264_at_tn.png
| GeneAtlas_image2 = PBB_GE_CPT2_204263_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004095 |text = carnitine O-palmitoyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006635 |text = fatty acid beta-oxidation}} {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1376
| Hs_Ensembl = ENSG00000157184
| Hs_RefseqProtein = NP_000089
| Hs_RefseqmRNA = NM_000098
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 53434689
| Hs_GenLoc_end = 53626815
| Hs_Uniprot = P23786
| Mm_EntrezGene = 12896
| Mm_Ensembl = ENSMUSG00000028607
| Mm_RefseqmRNA = NM_009949
| Mm_RefseqProtein = NP_034079
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 107401912
| Mm_GenLoc_end = 107421466
| Mm_Uniprot = Q3TFS0
}}
}}
'''Carnitine palmitoyltransferase II''', also known as '''CPT2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carnitine palmitoyltransferase II precursor (CPT2) is a nuclear protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.<ref>{{cite web | title = Entrez Gene: CPT2 carnitine palmitoyltransferase II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1376| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bonnefont JP, Demaugre F, Prip-Buus C, ''et al.'' |title=Carnitine palmitoyltransferase deficiencies. |journal=Mol. Genet. Metab. |volume=68 |issue= 4 |pages= 424-40 |year= 2000 |pmid= 10607472 |doi= 10.1006/mgme.1999.2938 }}
*{{cite journal | author=van der Leij FR, Huijkman NC, Boomsma C, ''et al.'' |title=Genomics of the human carnitine acyltransferase genes. |journal=Mol. Genet. Metab. |volume=71 |issue= 1-2 |pages= 139-53 |year= 2000 |pmid= 11001805 |doi= 10.1006/mgme.2000.3055 }}
*{{cite journal | author=Sigauke E, Rakheja D, Kitson K, Bennett MJ |title=Carnitine palmitoyltransferase II deficiency: a clinical, biochemical, and molecular review. |journal=Lab. Invest. |volume=83 |issue= 11 |pages= 1543-54 |year= 2003 |pmid= 14615409 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSTB... {November 9, 2007 1:35:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CSTB image.jpg {November 9, 2007 1:36:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:36:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSTB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1stf.
| PDB = {{PDB2|1stf}}, {{PDB2|2oct}}
| Name = Cystatin B (stefin B)
| HGNCid = 2482
| Symbol = CSTB
| AltSymbols =; CST6; EPM1; PME; STFB
| OMIM = 601145
| ECnumber =
| Homologene = 79
| MGIid = 109514
| GeneAtlas_image1 = PBB_GE_CSTB_201201_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1476
| Hs_Ensembl = ENSG00000160213
| Hs_RefseqProtein = NP_000091
| Hs_RefseqmRNA = NM_000100
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 44016826
| Hs_GenLoc_end = 44020585
| Hs_Uniprot = P04080
| Mm_EntrezGene = 13014
| Mm_Ensembl = ENSMUSG00000005054
| Mm_RefseqmRNA = NM_007793
| Mm_RefseqProtein = NP_031819
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 77828799
| Mm_GenLoc_end = 77830755
| Mm_Uniprot = Q62426
}}
}}
'''Cystatin B (stefin B)''', also known as '''CSTB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).<ref>{{cite web | title = Entrez Gene: CSTB cystatin B (stefin B)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1476| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Turk V, Bode W |title=The cystatins: protein inhibitors of cysteine proteinases. |journal=FEBS Lett. |volume=285 |issue= 2 |pages= 213-9 |year= 1991 |pmid= 1855589 |doi= }}
*{{cite journal | author=Järvinen M, Rinne A, Hopsu-Havu VK |title=Human cystatins in normal and diseased tissues--a review. |journal=Acta Histochem. |volume=82 |issue= 1 |pages= 5-18 |year= 1988 |pmid= 3122506 |doi= }}
*{{cite journal | author=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5-12 |year= 1997 |pmid= 9007972 |doi= }}
*{{cite journal | author=Kos J, Lah TT |title=Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). |journal=Oncol. Rep. |volume=5 |issue= 6 |pages= 1349-61 |year= 1998 |pmid= 9769367 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DAZL... {November 9, 2007 1:36:19 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:36:59 PM PST}
- CREATED: Created new protein page: DAZL {November 9, 2007 1:37:08 PM PST}
- INFO: Beginning work on DKC1... {November 9, 2007 1:37:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:38:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dyskeratosis congenita 1, dyskerin
| HGNCid = 2890
| Symbol = DKC1
| AltSymbols =; DKC; NAP57; NOLA4; XAP101; dyskerin
| OMIM = 300126
| ECnumber =
| Homologene = 1045
| MGIid =
| GeneAtlas_image1 = PBB_GE_DKC1_201479_at_tn.png
| GeneAtlas_image2 = PBB_GE_DKC1_201478_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DKC1_216212_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003720 |text = telomerase activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005697 |text = telomerase holoenzyme complex}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1736
| Hs_Ensembl = ENSG00000130826
| Hs_RefseqProtein = NP_001354
| Hs_RefseqmRNA = NM_001363
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153644229
| Hs_GenLoc_end = 153659158
| Hs_Uniprot = O60832
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Dyskeratosis congenita 1, dyskerin''', also known as '''DKC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein (MPP1) gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita disease.<ref>{{cite web | title = Entrez Gene: DKC1 dyskeratosis congenita 1, dyskerin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1736| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marrone A, Dokal I |title=Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer. |journal=Expert reviews in molecular medicine |volume=6 |issue= 26 |pages= 1-23 |year= 2007 |pmid= 15613268 |doi= 10.1017/S1462399404008671 }}
*{{cite journal | author=Yamaguchi H |title=Mutations of telomerase complex genes linked to bone marrow failures. |journal=Journal of Nippon Medical School = Nihon Ika Daigaku zasshi |volume=74 |issue= 3 |pages= 202-9 |year= 2007 |pmid= 17625368 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EXT1... {November 9, 2007 1:38:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:39:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Exostoses (multiple) 1
| HGNCid = 3512
| Symbol = EXT1
| AltSymbols =; EXT; ttv
| OMIM = 608177
| ECnumber =
| Homologene = 30957
| MGIid = 894663
| GeneAtlas_image1 = PBB_GE_EXT1_201995_at_tn.png
| GeneAtlas_image2 = PBB_GE_EXT1_214985_at_tn.png
| Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0050508 |text = glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity}} {{GNF_GO|id=GO:0050509 |text = N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006024 |text = glycosaminoglycan biosynthetic process}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007369 |text = gastrulation}} {{GNF_GO|id=GO:0007492 |text = endoderm development}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0015012 |text = heparan sulfate proteoglycan biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2131
| Hs_Ensembl = ENSG00000182197
| Hs_RefseqProtein = NP_000118
| Hs_RefseqmRNA = NM_000127
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 118875910
| Hs_GenLoc_end = 119193119
| Hs_Uniprot = Q16394
| Mm_EntrezGene = 14042
| Mm_Ensembl = ENSMUSG00000061731
| Mm_RefseqmRNA = NM_010162
| Mm_RefseqProtein = NP_034292
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 52898747
| Mm_GenLoc_end = 53175446
| Mm_Uniprot = Q3V1P4
}}
}}
'''Exostoses (multiple) 1''', also known as '''EXT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses.<ref>{{cite web | title = Entrez Gene: EXT1 exostoses (multiple) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2131| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wuyts W, Van Hul W |title=Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes. |journal=Hum. Mutat. |volume=15 |issue= 3 |pages= 220-7 |year= 2000 |pmid= 10679937 |doi= 10.1002/(SICI)1098-1004(200003)15:3<220::AID-HUMU2>3.0.CO;2-K }}
*{{cite journal | author=Duncan G, McCormick C, Tufaro F |title=The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins. |journal=J. Clin. Invest. |volume=108 |issue= 4 |pages= 511-6 |year= 2001 |pmid= 11518722 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FMO3... {November 9, 2007 1:39:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:40:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Flavin containing monooxygenase 3
| HGNCid = 3771
| Symbol = FMO3
| AltSymbols =; FMOII; MGC34400; dJ127D3.1
| OMIM = 136132
| ECnumber =
| Homologene = 68130
| MGIid = 1100496
| GeneAtlas_image1 = PBB_GE_FMO3_40665_at_tn.png
| GeneAtlas_image2 = PBB_GE_FMO3_206496_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0004499 |text = flavin-containing monooxygenase activity}} {{GNF_GO|id=GO:0015036 |text = disulfide oxidoreductase activity}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031227 |text = intrinsic to endoplasmic reticulum membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2328
| Hs_Ensembl = ENSG00000007933
| Hs_RefseqProtein = NP_001002294
| Hs_RefseqmRNA = NM_001002294
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 169326642
| Hs_GenLoc_end = 169353583
| Hs_Uniprot = P31513
| Mm_EntrezGene = 14262
| Mm_Ensembl = ENSMUSG00000026691
| Mm_RefseqmRNA = NM_008030
| Mm_RefseqProtein = NP_032056
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 164790475
| Mm_GenLoc_end = 164821205
| Mm_Uniprot = Q3UEN4
}}
}}
'''Flavin containing monooxygenase 3''', also known as '''FMO3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GGCX... {November 9, 2007 1:40:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:41:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gamma-glutamyl carboxylase
| HGNCid = 4247
| Symbol = GGCX
| AltSymbols =; FLJ26629; VKCFD1
| OMIM = 137167
| ECnumber =
| Homologene = 639
| MGIid = 1927655
| GeneAtlas_image1 = PBB_GE_GGCX_205351_at_tn.png
| GeneAtlas_image2 = PBB_GE_GGCX_214006_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008488 |text = gamma-glutamyl carboxylase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0017187 |text = peptidyl-glutamic acid carboxylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2677
| Hs_Ensembl = ENSG00000115486
| Hs_RefseqProtein = NP_000812
| Hs_RefseqmRNA = NM_000821
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 85629718
| Hs_GenLoc_end = 85642090
| Hs_Uniprot = P38435
| Mm_EntrezGene = 56316
| Mm_Ensembl = ENSMUSG00000053460
| Mm_RefseqmRNA = NM_019802
| Mm_RefseqProtein = NP_062776
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 72343843
| Mm_GenLoc_end = 72360221
| Mm_Uniprot = Q3TME3
}}
}}
'''Gamma-glutamyl carboxylase''', also known as '''GGCX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLF4... {November 9, 2007 1:47:32 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:48:24 PM PST}
- CREATED: Created new protein page: KLF4 {November 9, 2007 1:48:31 PM PST}
- INFO: Beginning work on KRIT1... {November 9, 2007 1:28:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:29:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = KRIT1, ankyrin repeat containing
| HGNCid = 1573
| Symbol = KRIT1
| AltSymbols =; CAM; CCM1
| OMIM = 604214
| ECnumber =
| Homologene = 12746
| MGIid = 1930618
| GeneAtlas_image1 = PBB_GE_KRIT1_216713_at_tn.png
| Function = {{GNF_GO|id=GO:0005083 |text = small GTPase regulator activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 889
| Hs_Ensembl = ENSG00000001631
| Hs_RefseqProtein = NP_001013424
| Hs_RefseqmRNA = NM_001013406
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 91666219
| Hs_GenLoc_end = 91713350
| Hs_Uniprot = O00522
| Mm_EntrezGene = 79264
| Mm_Ensembl = ENSMUSG00000000600
| Mm_RefseqmRNA = NM_030675
| Mm_RefseqProtein = NP_109600
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 3809195
| Mm_GenLoc_end = 3847363
| Mm_Uniprot = Q5U463
}}
}}
'''KRIT1, ankyrin repeat containing''', also known as '''KRIT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Verlaan DJ, Davenport WJ, Stefan H, ''et al.'' |title=Cerebral cavernous malformations: mutations in Krit1. |journal=Neurology |volume=58 |issue= 6 |pages= 853-7 |year= 2002 |pmid= 11914398 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1I3... {November 9, 2007 1:48:31 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 1:49:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:49:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1I3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xv9.
| PDB = {{PDB2|1xv9}}, {{PDB2|1xvp}}
| Name = Nuclear receptor subfamily 1, group I, member 3
| HGNCid = 7969
| Symbol = NR1I3
| AltSymbols =; CAR; CAR1; MB67; MGC150433; MGC97144; MGC97209
| OMIM = 603881
| ECnumber =
| Homologene = 3759
| MGIid = 1346307
| GeneAtlas_image1 = PBB_GE_NR1I3_207007_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0004882 |text = androgen receptor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9970
| Hs_Ensembl = ENSG00000143257
| Hs_RefseqProtein = NP_001070937
| Hs_RefseqmRNA = NM_001077469
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 159466079
| Hs_GenLoc_end = 159474590
| Hs_Uniprot = Q14994
| Mm_EntrezGene = 12355
| Mm_Ensembl = ENSMUSG00000005677
| Mm_RefseqmRNA = NM_009803
| Mm_RefseqProtein = NP_033933
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173050645
| Mm_GenLoc_end = 173055519
| Mm_Uniprot = Q3UEP1
}}
}}
'''Nuclear receptor subfamily 1, group I, member 3''', also known as '''NR1I3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: NR1I3 nuclear receptor subfamily 1, group I, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9970| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAB11A... {November 9, 2007 1:45:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RAB11A image.jpg {November 9, 2007 1:45:52 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:46:05 PM PST}
- CREATED: Created new protein page: RAB11A {November 9, 2007 1:46:13 PM PST}
- INFO: Beginning work on RPS6KA5... {November 9, 2007 1:46:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RPS6KA5 image.jpg {November 9, 2007 1:47:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:47:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RPS6KA5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vzo.
| PDB = {{PDB2|1vzo}}
| Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 5
| HGNCid = 10434
| Symbol = RPS6KA5
| AltSymbols =; MGC1911; MSK1; MSPK1; RLPK
| OMIM = 603607
| ECnumber =
| Homologene = 48302
| MGIid = 1920336
| GeneAtlas_image1 = PBB_GE_RPS6KA5_204635_at_tn.png
| GeneAtlas_image2 = PBB_GE_RPS6KA5_204633_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0009605 |text = response to external stimulus}} {{GNF_GO|id=GO:0016572 |text = histone phosphorylation}} {{GNF_GO|id=GO:0042221 |text = response to chemical stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9252
| Hs_Ensembl = ENSG00000100784
| Hs_RefseqProtein = NP_004746
| Hs_RefseqmRNA = NM_004755
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 90406925
| Hs_GenLoc_end = 90596746
| Hs_Uniprot = O75582
| Mm_EntrezGene = 73086
| Mm_Ensembl = ENSMUSG00000021180
| Mm_RefseqmRNA = NM_153587
| Mm_RefseqProtein = NP_705815
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 100950828
| Mm_GenLoc_end = 101126078
| Mm_Uniprot = Q8C050
}}
}}
'''Ribosomal protein S6 kinase, 90kDa, polypeptide 5''', also known as '''RPS6KA5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SERPINH1... {November 9, 2007 1:27:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:28:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
| HGNCid = 1546
| Symbol = SERPINH1
| AltSymbols =; AsTP3; CBP1; CBP2; HSP47; PIG14; RA-A47; SERPINH2; gp46
| OMIM = 600943
| ECnumber =
| Homologene = 20331
| MGIid = 88283
| GeneAtlas_image1 = PBB_GE_SERPINH1_207714_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005518 |text = collagen binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 871
| Hs_Ensembl = ENSG00000149257
| Hs_RefseqProtein = NP_001226
| Hs_RefseqmRNA = NM_001235
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 74955043
| Hs_GenLoc_end = 74961473
| Hs_Uniprot = P50454
| Mm_EntrezGene = 12406
| Mm_Ensembl = ENSMUSG00000070436
| Mm_RefseqmRNA = XM_988921
| Mm_RefseqProtein = XP_994015
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 99219453
| Mm_GenLoc_end = 99227197
| Mm_Uniprot = Q3TJK3
}}
}}
'''Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)''', also known as '''SERPINH1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.<ref>{{cite web | title = Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=871| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Razzaque MS, Taguchi T |title=The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases. |journal=Histol. Histopathol. |volume=14 |issue= 4 |pages= 1199-212 |year= 1999 |pmid= 10506936 |doi= }}
*{{cite journal | author=Gettins PG |title=Serpin structure, mechanism, and function. |journal=Chem. Rev. |volume=102 |issue= 12 |pages= 4751-804 |year= 2003 |pmid= 12475206 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TEC... {November 9, 2007 1:42:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TEC image.jpg {November 9, 2007 1:42:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:43:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TEC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl5.
| PDB = {{PDB2|1gl5}}
| Name = Tec protein tyrosine kinase
| HGNCid = 11719
| Symbol = TEC
| AltSymbols =; MGC126760; MGC126762; PSCTK4
| OMIM = 600583
| ECnumber =
| Homologene = 1302
| MGIid = 98662
| GeneAtlas_image1 = PBB_GE_TEC_206301_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7006
| Hs_Ensembl = ENSG00000135605
| Hs_RefseqProtein = NP_003206
| Hs_RefseqmRNA = NM_003215
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 47832557
| Hs_GenLoc_end = 47966638
| Hs_Uniprot = P42680
| Mm_EntrezGene = 21682
| Mm_Ensembl = ENSMUSG00000029217
| Mm_RefseqmRNA = NM_013689
| Mm_RefseqProtein = NP_038717
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 73034869
| Mm_GenLoc_end = 73147618
| Mm_Uniprot = Q3U436
}}
}}
'''Tec protein tyrosine kinase''', also known as '''TEC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.<ref>{{cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mano H |title=Tec family of protein-tyrosine kinases: an overview of their structure and function. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 267-80 |year= 2000 |pmid= 10647781 |doi= }}
*{{cite journal | author=Yang WC, Collette Y, Nunès JA, Olive D |title=Tec kinases: a family with multiple roles in immunity. |journal=Immunity |volume=12 |issue= 4 |pages= 373-82 |year= 2000 |pmid= 10795735 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFF3... {November 9, 2007 1:43:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TFF3 image.jpg {November 9, 2007 1:43:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:43:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TFF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e9t.
| PDB = {{PDB2|1e9t}}, {{PDB2|1pe3}}
| Name = Trefoil factor 3 (intestinal)
| HGNCid = 11757
| Symbol = TFF3
| AltSymbols =; HITF; ITF; TFI; hP1.B
| OMIM = 600633
| ECnumber =
| Homologene = 2427
| MGIid = 104638
| GeneAtlas_image1 = PBB_GE_TFF3_204623_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7033
| Hs_Ensembl = ENSG00000160180
| Hs_RefseqProtein = NP_003217
| Hs_RefseqmRNA = NM_003226
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42599751
| Hs_GenLoc_end = 42608775
| Hs_Uniprot = Q07654
| Mm_EntrezGene = 21786
| Mm_Ensembl = ENSMUSG00000024029
| Mm_RefseqmRNA = NM_011575
| Mm_RefseqProtein = NP_035705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30852327
| Mm_GenLoc_end = 30856623
| Mm_Uniprot = Q62395
}}
}}
'''Trefoil factor 3 (intestinal)''', also known as '''TFF3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF3 trefoil factor 3 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7033| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoffmann W, Jagla W, Wiede A |title=Molecular medicine of TFF-peptides: from gut to brain. |journal=Histol. Histopathol. |volume=16 |issue= 1 |pages= 319-34 |year= 2001 |pmid= 11193208 |doi= }}
*{{cite journal | author=Hoffmann W, Jagla W |title=Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. |journal=Int. Rev. Cytol. |volume=213 |issue= |pages= 147-81 |year= 2002 |pmid= 11837892 |doi= }}
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFR2... {November 9, 2007 1:43:58 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:44:54 PM PST}
- CREATED: Created new protein page: TFR2 {November 9, 2007 1:45:02 PM PST}
- INFO: Beginning work on TRA@... {November 9, 2007 1:41:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:42:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T cell receptor alpha locus
| HGNCid = 12027
| Symbol = TRA@
| AltSymbols =; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; TCRA; TCRD; TRA; TRDD3
| OMIM = 186880
| ECnumber =
| Homologene =
| MGIid =
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042287 |text = MHC protein binding}} {{GNF_GO|id=GO:0042605 |text = peptide antigen binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6955
| Hs_Ensembl =
| Hs_RefseqProtein =
| Hs_RefseqmRNA =
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''T cell receptor alpha locus''', also known as '''TRA@''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRIM5... {November 9, 2007 1:51:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:52:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tripartite motif-containing 5
| HGNCid = 16276
| Symbol = TRIM5
| AltSymbols =; RNF88; TRIM5alpha
| OMIM = 608487
| ECnumber =
| Homologene = 75345
| MGIid = 2441735
| GeneAtlas_image1 = PBB_GE_TRIM5_210705_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 85363
| Hs_Ensembl = ENSG00000132256
| Hs_RefseqProtein = NP_149023
| Hs_RefseqmRNA = NM_033034
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 5641363
| Hs_GenLoc_end = 5850164
| Hs_Uniprot = Q9C035
| Mm_EntrezGene = 319236
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_175677
| Mm_RefseqProtein = NP_783608
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tripartite motif-containing 5''', also known as '''TRIM5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Five alternatively spliced transcript variants for this gene have been described. However, the full length nature of two of the variants has not been determined.<ref>{{cite web | title = Entrez Gene: TRIM5 tripartite motif-containing 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85363| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luban J |title=Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. |journal=J. Virol. |volume=81 |issue= 3 |pages= 1054-61 |year= 2007 |pmid= 16956947 |doi= 10.1128/JVI.01519-06 }}
*{{cite journal | author=Freed EO, Mouland AJ |title=The cell biology of HIV-1 and other retroviruses. |journal=Retrovirology |volume=3 |issue= |pages= 77 |year= 2006 |pmid= 17083721 |doi= 10.1186/1742-4690-3-77 }}
}}
{{refend}}
{{protein-stub}}
end log.
.jpg)
