She is the vocalist of Gothenburg-based electronic band Little Dragon, which she established with her close high school friends Erik Bodin (drums), Fredrik Wallin (bass) and Håkan Wirenstrand (keyboards). Nagano worked with Swedish nu jazz duo Koop on the songs "Come to Me", "I See a Different You", and "Whenever There Is You". She and Erik Bodin play live with fellow Gothenburg artist, José González. Nagano is featured on Gorillaz's 2010 album Plastic Beach on the songs "Empire Ants" and "To Binge", both of which she co-wrote. In 2011, she was featured on SBTRKT's eponymous debut album with her vocals on the song "Wildfire". Nagano is also featured on Raphael Saadiq's 2011 album Stone Rollin' on the song "Just Don't". Nagano also provided vocals for "Scale It Back" on DJ Shadow's 2011 album The Less You Know, the Better and for "Descending", "Higher Res", and "Thom Pettie" from Big Boi's 2012 album Vicious Lies and Dangerous Rumors.