TBC1D4
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TBC1D4, AS160, NIDDM5, TBC1 domain family member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 612465; MGI: 2429660; HomoloGene: 45451; GeneCards: TBC1D4; OMA:TBC1D4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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TBC1 domain family, member 4, also known as TBC1D4 and AS160, is a human gene.[5]
The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt, which phosphorylates AS160 after insulin stimulation.[6] Insulin stimulation of fat and muscle cells results in translocation of the glucose transporter GLUT4 to the plasma membrane, and this translocation process is dependent on phosphorylation of AS160.[7] The role of AS160 in GLUT4 translocation is mediated by its GTPase activating domain, which interacts with Rab proteins in vesicle formation. Specifically, AS160 activates RAB2A, RAB8A, RAB10 and RAB14.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136111 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033083 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TBC1D4 TBC1 domain family, member 4".
- ^ Kane S, Sano H, Liu SC; et al. (2002). "A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain". J. Biol. Chem. 277 (25): 22115–8. doi:10.1074/jbc.C200198200. PMID 11994271.
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(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Sano H, Kane S, Sano E; et al. (2003). "Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation". J. Biol. Chem. 278 (17): 14599–602. doi:10.1074/jbc.C300063200. PMID 12637568.
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(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Mîinea CP, Sano H, Kane S; et al. (2005). "AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain". Biochem. J. 391 (Pt 1): 87–93. doi:10.1042/BJ20050887. PMID 15971998.
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