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Protein RAB8A PDB 2fu5.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RAB8A, MEL, RAB8, member RAS oncogene family
External IDs MGI: 96960 HomoloGene: 100934 GeneCards: RAB8A
RNA expression pattern
PBB GE RAB8A 208819 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 16.11 – 16.13 Mb Chr 8: 72.16 – 72.18 Mb
PubMed search [1] [2]
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Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[3][4][5]


The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[5]


RAB8A has been shown to interact with Optineurin[6] and MAP4K2.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (Aug 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene. 6 (8): 1347–51. PMID 1886711. 
  4. ^ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (Oct 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". The Journal of Cell Biology. 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815Freely accessible. PMID 8408203. 
  5. ^ a b "Entrez Gene: RAB8A RAB8A, member RAS oncogene family". 
  6. ^ Hattula K, Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Current Biology. 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. PMID 11137014. 
  7. ^ Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423Freely accessible. PMID 8643544. 

Further reading[edit]