Clindamycin/tretinoin: Difference between revisions
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'''Clindamycin/tretinoin''' is a [[Topical gels|topical gel]] used in the treatment of [[acne]]. The two active ingredients are the antibiotic [[clindamycin]] phosphate (1.2%) and [[tretinoin]] (0.025%), a [[retinoid]].<ref>{{cite web |url=http://www.ziana.com |title=Ziana Gel |access-date= |
'''Clindamycin/tretinoin''' is a [[Topical gels|topical gel]] used in the treatment of [[acne]]. The two active ingredients are the antibiotic [[clindamycin]] phosphate (1.2%) and [[tretinoin]] (0.025%), a [[retinoid]].<ref>{{cite web |url=http://www.ziana.com |title=Ziana Gel |access-date=16 November 2008}}</ref> The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.<ref>{{Cite web|title=BNF is only available in the UK|url=https://www.nice.org.uk/bnf-uk-only|access-date=5 October 2021|website=NICE}}</ref> The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.<ref>{{cite journal | vauthors = Zasada M, Budzisz E | title = Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments | journal = Postepy Dermatologii I Alergologii | volume = 36 | issue = 4 | pages = 392–397 | date = August 2019 | pmid = 31616211 | pmc = 6791161 | doi = 10.5114/ada.2019.87443 }}</ref> The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.<ref>{{cite web |url=http://www.medicis.com/products/pi/pi_ziana.pdf |title=Ziana Prescribing Information |access-date=15 November 2008 |archive-url=https://web.archive.org/web/20070617182911/http://www.medicis.com/products/pi/pi_ziana.pdf |archive-date=17 June 2007 |url-status=dead }}</ref> Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or [[colitis]]. Sun exposure while using this preparation can cause skin irritation.<ref>{{Cite journal |last=Kurokawa |first=Ichiro |date=19 May 2016 |title=Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris. |doi=10.3410/f.726161029.793518600 |doi-access=free }}</ref> |
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== Citations == |
== Citations == |
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Latest revision as of 06:50, 20 June 2024
| Combination of | |
|---|---|
| Clindamycin phosphate | Antibiotic |
| Tretinoin | Topical retinoid |
| Clinical data | |
| Trade names | Ziana, others |
| MedlinePlus | a609005 |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | |
| KEGG | |
| (verify) | |
Clindamycin/tretinoin is a topical gel used in the treatment of acne. The two active ingredients are the antibiotic clindamycin phosphate (1.2%) and tretinoin (0.025%), a retinoid.[1] The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.[2] The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.[3] The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.[4] Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or colitis. Sun exposure while using this preparation can cause skin irritation.[5]
Citations
[edit]- ^ "Ziana Gel". Retrieved 16 November 2008.
- ^ "BNF is only available in the UK". NICE. Retrieved 5 October 2021.
- ^ Zasada M, Budzisz E (August 2019). "Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments". Postepy Dermatologii I Alergologii. 36 (4): 392–397. doi:10.5114/ada.2019.87443. PMC 6791161. PMID 31616211.
- ^ "Ziana Prescribing Information" (PDF). Archived from the original (PDF) on 17 June 2007. Retrieved 15 November 2008.
- ^ Kurokawa I (19 May 2016). "Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris". doi:10.3410/f.726161029.793518600.
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