Adapalene/benzoyl peroxide

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Adapalene/benzoyl peroxide
Adapalene and benzoyl peroxide.svg
Combination of
Benzoyl peroxidePeroxide
Clinical data
Trade namesEpiduo
  • US: C (Risk not ruled out)
Routes of
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
 ☒N☑Y (what is this?)  (verify)

Adapalene/benzoyl peroxide is a prescription medication combination for the treatment of severe acne vulgaris; marketed by Galderma under the trade name Epiduo.[1] Its trade name in Canada is TactuPump, where it was previously known as Tactuo.[2] It consists of a combination of adapalene (0.1%) and benzoyl peroxide (2.5%) in a topical gel formulation.[1] Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[3]


People are advised to exercise caution in using Epiduo together with other skin products containing sulfur, resorcinol, or salicylic acid, or with medicated or abrasive dirts and cleansers.[4] Skin products with high levels of alcohol or astringents should also be avoided.[4] Using topical products with a strong drying effect in combination with Epiduo can increase irritation.[4] The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[5] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

Side effects[edit]

Commonly reported side effects include the following:[4]


People who use adapalene/benzoyl peroxide are advised to avoid exposure to sunlight and sunlamps, and use sunscreen when these cannot be avoided.[4]


  1. ^ a b "FDA OKs New Acne Gel Epiduo". Retrieved 2012-01-25.
  2. ^ "How Does Benzoyl Peroxide Work on Acne".
  3. ^ Tan, Jerry; Gollnick, Harald p. M.; Loesche, Christian; Ma, Y. May; Gold, Linda Stein (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678.
  4. ^ a b c d e "Full prescribing information" (PDF). Retrieved 2012-01-25.
  5. ^ Dréno, B.; Kaufmann, R.; Talarico, S.; Torres Lozada, V.; Rodríguez-Castellanos, M.A.; Gómez-Flores, M.; De Maubeuge, J.; Berg, M.; Foley, P.; Sysa-Jedrzejowska, A.; Kerrouche, N.; Paliargues, F.; Bettoli, V. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". British Journal of Dermatology. 165 (2): 383–390. doi:10.1111/j.1365-2133.2011.10374.x.

External links[edit]