User talk:Andrew73

Welcome!

Welcome to Wikipedia, Andrew73! My name is Ryan, aka Acetic Acid. I noticed that you were new and haven't received any messages yet. I just wanted to see how you were doing. Wikipedia can be a little intimidating at first, since it uses different formatting than other sites that use HTML and CSS. In the long run, though, you'll find that the WikiSyntax is a lot easier and faster than those other ways. Here are a few links to get you started:

• How to edit a page
• Editing, policy, conduct, and structure tutorial
• Picture tutorial
• How to write a great article

There are a lot of policies and guides to read, but I highly recommend reading over those first. If you have any questions, feel free to leave me a message on my talk page. Please be sure to sign your name on Talk Pages using four tildes (~~~~) to produce your name and the current date, along with a link to your user page. This way, others know when you left a message and how to find you. It's easier than having to type out your name, right? :)

I hope you enjoy contributing to Wikipedia. We can use all the help we can get! Have a nice day. Sincerely, Acetic'^Acid 22:05, September 5, 2005 (UTC)

Maze v maze

Andrew,

I added the bit about the Maze procedure to the atrial fibrillation page. Both capitalizations have been used. Cox, who developed the procedure, prefers Maze in his recent publications:

• Cox JL. The Role of Surgical Intervention in the Management of Atrial Fibrillation. Tex Heart Inst J. 2004; 31(3): 257–265. PMID 15562846

I think that he actually intends it to be a proper noun, like "Kleenex", to distinguish it from other (lesser) "Maze-like" procedures. I'd rather not go around and around on this, but I'd prefer the Maze capitalization so that it is internally consistent, in agreement with Cox, and consistent with the other wikipedia subject that I wrote, minimaze. There I have been very careful to use what I believe to be the proper capitalizations.

So I intend to change the capitalizations back to Maze where appropriate unless you plan to change them back again to maze.

jamesmcclelland 20:15, 2 January 2006 (UTC)

Thanks. I responded on Talk:Atrial fibrillation. Andrew73 21:07, 2 January 2006 (UTC)

Medic?

Hi Andrew, your contribs suggest a medical background. Would you like to join Wikipedia:WikiProject Clinical medicine? Please have a look. JFW | T@lk 07:10, 6 September 2005 (UTC)

You a hematologist then? JFW | T@lk 17:02, 22 September 2005 (UTC)

Training to become a hematologist! Andrew73 00:43, 11 October 2005 (UTC)

Paid Editing Project

Hi: My name is Tess and I work for a global independent research firm in New York. I am interested in hiring you for a Wikipedia editing project, based on your technology and medical experience and expertise. I attempted to email you through your user page. If you received it, please read it over and contact me with any questions. If you did not receive this email, please let me know and I would be more than happy to tell you more about this project. (You can call 512-651-1797 or email tfurman@glgroup.com). Thank you and I hope to hear from you soon! Tess - Gerson Lehrman Group 18:41, 28 September 2005 (UTC)

Erythromelalgia

I'm not sure if you're right about it not being a disease. OMIM seems to be happy to classify it as a clinical entity. JFW | T@lk 21:45, 8 October 2005 (UTC)

Good point. In the the thrombocytosis section, erythromelalgia was referring to the symptoms of erythromelalgia as secondary to e.g. essential thrombocytosis, rather than primary erythromelalgia in and of itself. Andrew73 21:52, 8 October 2005 (UTC)

Bone marrow biopsy

Hi,

I dewikified aspirate in this article as it's redirecting to aspiration (phonetics) which seems completely irrelevant. There's also aspiration (medicine) but that doesn't seem to fit with what the article says either (could be wrong - I'm not a medic). If not, could you mention what an aspirate is in the article? Thanks, CTOAGN 23:23, 10 October 2005 (UTC)

Embarrassingly, I didn't see your prior edit! I created a disambiguation page for aspirate and removed the redirect to aspiration (phonetics). I now wikified aspirate to the page describing needle aspiration biopsy 00:43, 11 October 2005 (UTC)

The CMAJ is a general medical journal

See the about CMAJ. The short of the long of it is the Annals of Internal Medicine is an internal medicine journal.

The article says: "It is considered to be one of the top five general medical journals..." [emphasis added]

Annals of Internal Medicine isn't a general medical journal. Nephron 00:55, 15 October 2005 (UTC)

Interestingly, if you go to the ISI Web of Knowledge, Journal Citation Reports, where the impact factors are calculated and the journals are ranked, the category is "medicine, general & internal," so general medical and internal medicine journals are actually lumped together! So in the actual ranking scheme, it's #8. Andrew73 12:58, 15 October 2005 (UTC)

PE

I'm curious if you are aware of any historical accounts on the recognition of PE as a clinical entity. The article now mentions some classical papers, but not when the signs and symptoms (and etiology) of VTE/PE were first recognised.

You're closer to Dr Goldhaber than me - he may be the person to ask :-) JFW | T@lk 06:51, 16 October 2005 (UTC)

I'll look into those classical papers later today! Andrew73 12:12, 16 October 2005 (UTC)

Re:Heparin-Induced Thrombocytopenia

Makes sense...I don't have any problem with your removal. I was veiwing that page as a drug-induced thrombocytopenia page with heparin being the classical example, but I now agree that their inclusion was out of place. Later.--Jfurr1981 20:05, 16 October 2005 (UTC)

MDS

Thanks for adding that to the page. It's much better now imo. CTOAGN 23:15, 17 October 2005 (UTC)

Blood (journal)

I've started Blood (journal). I could not find a good historical account about the journal. Are you aware of any good resource for this purpose? JFW | T@lk 03:39, 21 October 2005 (UTC)

Well the first issue is available online as a pdf, though it does not offer any additional information! Andrew73 11:31, 21 October 2005 (UTC)

Do you have an URL? Can't find it. And Dr Damashek must have written something quotable? Heck, this guy and Max Wintrobe were the grand men of US haematology! JFW | T@lk 22:15, 22 October 2005 (UTC)

The url is | http://www.bloodjournal.org/content/vol1/issue1/. (It turns out that all of the issues of Blood are available online!). I can e-mail you the pdf if you don't have access to it. Andrew73 23:07, 22 October 2005 (UTC)

I just wrote up Max Wintrobe. Would you mind having a look? JFW | T@lk 01:30, 23 October 2005 (UTC)

Very impressed! Andrew73

Who are you?

[Name deleted]? Just a guess...heme/onc, updating MGH and Harvard Medical School websites...probably born in 1973. If not and you are at MGH, I probably still know you! InvictaHOG 02:31, 23 October 2005 (UTC)

Your detective work serves you well! Now do I know you?! Andrew73 02:45, 23 October 2005 (UTC)

Probably not, though I've met you before. I'm a third year med/peds at MGH, [Name deleted]. I've used your eponyms program since med school. It should be a wiki! InvictaHOG 03:24, 23 October 2005 (UTC)

Of course I know you [Name deleted]! We've had patients together! Andrew73 14:34, 23 October 2005 (UTC)

Andrew, do you indeed have an eponyms program? Would you licence its contents under the GFDL? I've meant to approach Ole Daniel Enersen, the webmaster of http://www.whonamedit.com, about the copyright status of his site. JFW | T@lk 11:11, 23 October 2005 (UTC)

Yes I do indeed have an eponyms program for the Palm OS. At this time though, I'd like to decline the invitation to wiki its contents...perhaps this is out of a quixotic hope to do something more with it in the future! Andrew73 14:34, 23 October 2005 (UTC)

Extra period in PMID converter?

Happy to hear you like the converter. :-) Actually, the converter isn't adding the period; it's just that Template:Journal reference issue always adds a period to titles and in your case the title has already got a period of its own (see [1]). I've tweaked the converter so it removes trailing periods in titles, but this won't solve the larger issue of using Template:Journal reference issue et al to reference articles whose titles have trailing punctuation. For example, "Long-term potentiation--A decade of progress?" [2] would still render pretty oddly. To solve this the right way would require lots of updates to existing wiki articles using it, but Template:Journal reference issue should probably let the user provide their own trailing punctuation in journal article titles. --David Iberri | Talk 16:01, 28 October 2005 (UTC)

Thanks. I've actually taken the liberty of removing the period from the template, and now the articles display correctly! Andrew73 14:50, 29 October 2005 (UTC)

Emergency department

The above article is likely to be selected as next weeks choice at Wikipedia:Article Improvement Drive if it receives a few more votes. It is of interest to Wikipedians in general, and would improve the profile of medical-related topics on Wikipedia. To vote, click on WP:AID and sign your name in the Emergency department section.--File Éireann 18:48, 14 November 2005 (UTC)

Emergency department

Many thanks for your support!--File Éireann 23:48, 23 November 2005 (UTC)

COMMENT ON MUMPS PAGE BY USER MIDGELEY

Why did you restore a comment that was deleted because it was invalid? The introduction of MMR in 1988 was planned and known about before 1988. The comment added is therefore incorrect and disruptive. It is not an assertion that events in 1988 caused events in 1987. As a BMA member User Midgeley knows that is the case.

Is this not taking things to an unusual level?

80.1.224.12 14:23, 20 December 2005 (UTC)

I restored the comment (invalid or valid) because it's on a discussion page, not the actual article. Andrew73 14:26, 20 December 2005 (UTC)

Not clear what the point is here. Can you elucidate please?

80.1.224.12 14:44, 20 December 2005 (UTC)

Since it's a discussion page, comments should be left in place for the sake of discussion, even if it's incorrect or disruptive. Perhaps you could add a comment to argue your point. Andrew73 15:24, 20 December 2005 (UTC)

Breast Cancer Adjuvant external link

If you feel the Adjuvant external link is especially necessary on the Breast Cancer#External links page, can you add a brief explanation of it? There are hundreds of "good" cancer resources out there, and this page shouldn't be just a listing of them. If that one, in particular, is unusually notable (which it might be -- I don't know enough about it), it'd be helpful to at least let a reader know what it is or why she should click. Jkatzen 19:32, 24 December 2005 (UTC)

I agree, the external link section has the potential to be populated with trivial or commercial links. But Adjuvant! is actually used in clinical practice, it's referenced further on PMID 11181660 In any event, I expanded its description on the article. Andrew73 19:39, 24 December 2005 (UTC)

Quack

Wikipedia is not a sitting duck for quacks. In recognition of your efforts the sitting duck award. JFW 00:29, 26 December 2005 (UTC).

RfC on See also

I started an RfC on the vaccine/autism See Also sections at Talk:Thimerosal InvictaHOG 05:42, 2 January 2006 (UTC)

Polio edits

Will you stop removing my links [3]. john 13:51, 2 January 2006 (UTC)

John, the link to Jim West was a non sequitur in the polio vaccine article. Why not discuss his relevance in the text of the article rather than a link that is out of the blue? Andrew73 15:30, 2 January 2006 (UTC)

Thanks for vigilance against vandalism.

Hello,

I noticed that you caught the vandalism to the article on Breast cancer. Thanks for catching that! Folajimi^(talk)

Biographies

and ad hominem etc etc... I see you picked out some continuing adverse editing on Mumps.

I think the anti-vaccinationists article has the potential to be both interesting and good, if it is not disrupted. The scatter of failed biogrpahies of people whose only noticeable trait is to have been against vaccination doesn't help anything, and I wonder if we can do an effort to roll the whole damn lot up into paragprahs in the one article, unless any of them actually did interesti ng things as well. mendelsohn might make it I think, none of the others.

I think it would be tedious if all the medical biographies got a line "he was in favour of vaccination and called people who were not idiots" - it would do for Osler... but it would not be encyclopedic there, and therefore its obverse is not encyclopedic in a (non-)biography.

Advice? Midgley 23:04, 28 January 2006 (UTC)

Personally, I'm not too opposed to keeping their biographies as separate articles, even if their biographies aren't too notable. I do agree with your efforts with the anti-vaccinationists article! In the end, I don't think there's a great solution. If there was one, I don't think this anti-vaccine controvery would still be an issue for over a century! Andrew73 23:25, 28 January 2006 (UTC)

Vaccine injury

Well done on balancing the POV in vaccine injury. JFW | T@lk 02:54, 7 February 2006 (UTC)

Equal signs

If you use two equal signs, it will turn the text into a first-level section heading. In principle, the single equal sign would produce the equivalent of a page heading, which by definition every page already has (and should be unique). If you use == and you get a subsection of something else, it's because that "something" has been tagged (wrongly) with a single equal sign. See Help:Section for details. --Pablo D. Flores (Talk) 15:24, 8 February 2006 (UTC)

Vandalism fighters can make mistakes

You deleted this (Influenza Report 2006) from the external links section of Influenza. I put it back. It is an online book with research level quality information and I highly recommend it.

Here is a sample:

In order to gain infectivity, influenza A virions must incorporate HA proteins which have been endoproteolytically processed from a HA0 precursor to a disulphide-linked HA1,2 dimer (Chen 1998). The newly created N-terminus of the HA2 subunit harbours a fusogenic peptide, composed of a highly lipophilic domain (Skehel 2001). This domain is vitally required during the fusion process of viral and lysosomal membranes because it initiates the penetration process of viral genomic segments into the host cell cytoplasm. The cleavage site of the HA of low pathogenic viruses is composed of two basic amino acids at positions -1/-4 (H5) and -1/-3 (H7) (Wood 1993). These sites are accessible to tissue-specific trypsin-like proteases which are preferentially expressed at the surface of respiratory and gastrointestinal epithelia. Therefore, efficient replication of LPAIVs is believed to be largely confined to these sites, at least in their natural hosts. In contrast, the cleavage site of HPAI viruses generally contains additional basic amino acids (arginine and/or lysine) which renders it processible for subtilysin-like endoproteases specific for a minimal consensus sequence of -R-X-K/R-R- (Horimoto 1994, Rott 1995). Proteases of this type (e.g. furin, proprotein-convertases) are active in virtually every tissue throughout the body. Therefore, viruses carrying these mutations have an advantage for replicating unrestrictedly in a systemic manner. This process has been documented in the field on several occasions. In Italy, for example, an LPAI H7N1 virus circulated for several months in the turkey and chicken population before, in December 1999, an HPAI H7N1 virus, distinguishable from its precursor only by its polybasic cleavage site, sprang up and caused devastating disease (Capua 2000).

It has been hypothesised that the HA gene of the H5 and H7 subtypes harbour distinct secondary RNA structures which favour insertional mutations (codon duplications) by a re-copying mechanism of the viral polymerase unit at a purine-rich sequence stretch encoding the endoproteolytic cleavage site of these HA proteins (Garcia 1996, Perdue 1997). This, and probably other mechanisms too, such as nucleotide substitutions or intersegmental recombination (Suarez 2004, Pasick 2005), may lead to the incorporation of additional basic amino acid residues. The latter has been experimentally proven by the generation of HPAIV from LPAIV precursors following repeated passaging in vitro and in vivo by site-directed mutagenesis (Li 1990, Walker and Kawaoka 1993, Horimoto and Kawaoka 1995, Ito 2001). Conversely, removal by reverse genetics of the polybasic cleavage site attenuates the HPAI phenotype (Tian 2005).

There are, however, viral strains in which the nucleotide sequence encoding the HA cleavage site and the pheno-/pathotype did not match in the predicted way: a Chilean H7N3 HPAIV which arose by intersegmental recombination displayed basic amino acid residues only at positions -1, -4 and -6 (Suarez 2004). Comparable examples exist for the H5 lineage (Kawaoka 1984). On the other hand, an H5N2 isolate from Texas was shown to harbour the HPAIV cleavage site consensus sequence, yet was clinically classified as LPAI (Lee 2005). These data re-emphasise the polygenic and intricate nature of influenza virus pathogenicity.

Fortunately, nascency of HPAI phenotypes in the field appears to be a rare event. During the last fifty years, only 24 primary HPAI outbreaks caused by HPAIV, which likely arose de novo in this way in the field, have been reported world-wide (Table 1).

In addition, HPAIV have been shown to be able to infect mammals, and humans in particular. This has especially been observed for the Asian lineage H5N1 (WHO 2006). Host-dependent pathogenicity of HPAIV H5N1 for mammals has been studied in several model species: mice (Lu 1999, Li 2005a), ferrets (Zitzow 2002, Govorkova 2005), cynomolgous monkeys (Rimmelzwaan 2001) and pigs (Choi 2005). The outcome of infection was dependent on the viral strain and species of host. Ferrets appeared to mirror pathogenicity in humans better than mice (Maines 2005).

A number of genetic markers believed to be involved in pathogenicity have been located in different segments of the Z genotype of H5N1 (Table 2). Among these, mechanisms of interference with first-line defence mechanisms of the host, such as the interferon system, through the NS-1 gene product have received marked interest. Experimentally, it has been demonstrated using reverse genetics, that NS-1 proteins of some H5N1 strains carrying glutamic acid at position 92 are capable of circumventing the antiviral effects of interferon and tumour necrosis factor-alpha, eventually leading to enhanced replication in, and reduced clearance from, the infected host (Seo 2002+2004). In addition, immune-mediated damage resulting from NS-1-mediated disruption of cytokine networks may account for parts of the lung lesions (Cheung 2002, Lipatov 2005). However, none of the mutations (Table 2) on its own represents a true prerequisite for pathogenicity in mammals (Lipatov 2003). Therefore, optimal gene constellations, to a large extent, appear to drive pathotype specificities in a host-dependent manner in mammals (Lipatov 2004).

Thanks for helping make Wikipedia better. WAS 4.250 14:09, 15 February 2006 (UTC)

Thanks for catching this! Andrew73 14:20, 15 February 2006 (UTC)

Ficoll

Andrew73,

Thanks for the correction on my entry about using Ficoll to separate islets from pancreatic tissue.

Mouselady

Invitation

Please weigh in on this proposal and see User:Leifern/Wikiproject health controversies. Thanks in advance, and feel free to spread the word. --Leifern 17:25, 1 March 2006 (UTC)

Talk:Breast cancer

Left a note for you there. - RoyBoy ⁸⁰⁰ 03:08, 31 March 2006 (UTC)

“Medicine” on MCOTW

After a bit of inactivity, Medicine has been selected as the new medicine collaboration of the week. I am taking the unusual step of informing all participants, not just those who voted for it, since I feel that it is important that this highest-level topic for our collaboration be extremely well-written. In addition, it is a core topic for Wikipedia 1.0 and serves as the introduction to our other articles. Yet general articles are the ones that are most difficult for individuals to write, which is why I have invited all participants. I hope it isn't an intrusion; I don't make plan to make a habit of sending out these messages. — Knowledge Seeker দ 02:16, 16 April 2006 (UTC)

An article you edited

Wikipedia:Articles_for_deletion/Brian_Deer. By User:Whaleto Midgley 19:14, 16 April 2006 (UTC)

Arbitration on Biological psychiatry

Andrew73, first of all, thanks for your expert help with the Biological psychiatry article. Our goal is to make it scholarly and encyclopedic in tone and content. However we have a major problem in that Cesar Tort and Ombudsman are aggresively pushing Peter Breggin-style content into the article. That of course isn't consistent with an encyclopedia.

I asked Cesar Tort and Ombudsman for mediation or arbitration. They didn't respond so regretfully we must proceed. Without mediation, we go straight to arbitration. If you're willing to support this, please read the below. I'll file the request later today, unless you suggest otherwise. Joema 19:37, 19 April 2006 (UTC)

• Arbitration policy
• Arbitration template
• Arbitration evidence
• Wikipedia:Arbitration policy/Past decisions
• User:Snowspinner/Arbcom - Recommended reading: A guide to presenting effective Arbitration cases.