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{{notability|date=March 2014}}


'''Eric J. Nestler, M.D., Ph.D.''', is the Nash Family Professor of Neuroscience, Chairman of the Department of Neuroscience and Director of the Friedman Brain Institute at the [[Mount Sinai Hospital, New York|Mount Sinai Medical Center]] in [[New York City|New York]].<ref>[http://www.mountsinai.org/Find%20A%20Doctor/profile.do?id=0000072500004647234661&officeDrawer=pat Mount Sinai]</ref><ref>[http://mhprofessional.com/contributor.php?cat=116&id=39965 McGraw Hill Medical]</ref> His work in [[neuropsychopharmacology]] has been instrumental in forming a molecular approach to [[psychiatry]] and has furthered the understanding of the molecular basis of both depression and drug addiction,<ref>[http://findarticles.com/p/articles/mi_m0EIN/is_2005_Feb_17/ai_n9546261/ Bnet.com]</ref> using animal models to study the way drug use or stress affects the [[brain]].<ref>[http://www.futurestructuralbiology.org/c3speakers.pdf Future Structural Biology]</ref>
'''Eric J. Nestler, M.D., Ph.D.''', is the Nash Family Professor of Neuroscience, Chairman of the Department of Neuroscience and Director of the Friedman Brain Institute at the [[Mount Sinai Hospital, New York|Mount Sinai Medical Center]] in [[New York City|New York]].<ref name=MSH>{{cite web |url=http://www.mountsinai.org/profiles/eric-j-nestler |title=Mount Sinai Hospital Doctor Profile |publisher= |accessdate=9 June 2014 }}</ref><ref>{{cite web |url=http://mhprofessional.com/contributor.php?cat=116&id=39965 |title=McGraw Hill Medical |publisher= |accessdate=9 June 2014 }}</ref> His focus in [[neuropsychopharmacology]] concentrates on forming a molecular approach to [[psychiatry]] and furthering the understanding of the molecular basis of both depression and drug addiction, using animal models to study the way drug use or stress affects the [[brain]].<ref name=MSH/>


Dr. Nestler is the author (with [[Dennis S. Charney]]) of Neurobiology of Mental Illness (ISBN 0195189809), of Molecular Neuropharmacology (with Steven E. Hyman and Robert C. Malenka; ISBN 978-0-07-148127-4), and more than 400 chapters and peer-reviewed publications. He is active in eight research projects funded by the [[National Institute on Drug Abuse]] and the [[National Institute of Mental Health]]{{fact|date=February 2014}}{{when|date=February 2014}}.
Nestler is the author (with [[Dennis S. Charney]]) of ''Neurobiology of Mental Illness'' (ISBN 0195189809), of ''Molecular Neuropharmacology'' (with Steven E. Hyman and Robert C. Malenka; ISBN 978-0-07-148127-4), and more than 450 chapters and peer-reviewed publications.<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Nestler%20EJ[au] |title=PubMed |publisher=National Institutes of Health |accessdate=9 June 2014 }}</ref> He is active in seven research projects funded by the [[National Institute on Drug Abuse]] and the [[National Institute of Mental Health]].


==Biography==
==Biography==
===Education===
===Education===
Dr. Nestler, a graduate of Herricks High School (New Hyde Park, N.Y.), received his [[Bachelor of Arts|B.A.]], his [[Doctor of Philosophy|Ph.D.]] and his [[Doctor of Medicine|M.D.]] from [[Yale University]]. He completed his residency in psychiatry at both [[McLean Hospital]] in [[Massachusetts]] and Yale in 1987, then served as the Director of the Division of [[Molecular Psychiatry]] at Yale until 2000. He later served as Chairman of the Department of Psychiatry at the [[University of Texas Southwestern Medical Center at Dallas]].<ref>[http://archive.sciencewatch.com/nov-dec2001/sw_nov-dec2001_page3.htm Science Watch]</ref> In 2008, he joined the staff at Mount Sinai.
Nestler is a graduate of [[Herricks High School]] in [[New Hyde Park, New York]]. He received his [[Bachelor of Arts|B.A.]], his [[Doctor of Philosophy|Ph.D.]] and his [[Doctor of Medicine|M.D.]] from [[Yale University]]. He completed his residency in psychiatry at both [[McLean Hospital]] in [[Massachusetts]] and Yale in 1987.<ref name=MSH/>


===Career===
===Career===
Nestler has served on the Board of Scientific Counselors of the National Institute on Drug Abuse, on the National Advisory Mental Health Council for the National Institute of Mental Health, and as Council Member of the American College of Neuropsychopharmacology (for which he served as president in 2011) and the [[Society for Neuroscience]]. He is a member of the Scientific Advisory Board of the [[NARSAD|National Alliance for Research in Schizophrenia and Depression]] (now known as the [[Brain & Behavior Research Foundation]]) and of the International Mental Health Research Organization, as well as a member of the Board of Directors of the McKnight Endowment Fund in Neuroscience. He currently serves on the National Advisory Drug Abuse Council for the National Institute on Drug Abuse and was elected to the [[Institute of Medicine]] in 1998 and the [[American Academy of Arts and Sciences]] in 2005.<ref>[http://www.futurestructuralbiology.org/c3speakers.pdf Future Structural Biology]</ref><ref>[http://www.mcknight.org/neuroscience/snapshot/directors.aspx The McKnight Endowment Fund for Neuroscience]</ref>
Nestler served as the Director of the Division of Molecular Psychiatry at Yale until 2000, and as Chairman of the Department of Psychiatry at the [[University of Texas Southwestern Medical Center at Dallas]].<ref name=MSH/> He joined Mount Sinai in 2008. He has served on the Board of Scientific Counselors of the National Institute on Drug Abuse, on the National Advisory Mental Health Council for the National Institute of Mental Health, the National Advisory Drug Abuse Council for the National Institute on Drug Abuse,<ref>{{cite web |url=http://archives.drugabuse.gov/about/organization/nacda/minutes103rd.html |title=National Institute on Drug Abuse |publisher= |accessdate=9 June 2014 }}]</ref> as Council Member of the American College of Neuropsychopharmacology (for which he served as president in 2011) and the [[Society for Neuroscience]]. He is a member of the Scientific Advisory Board of the [[NARSAD|National Alliance for Research in Schizophrenia and Depression]] (now known as the [[Brain & Behavior Research Foundation]]) and of the International Mental Health Research Organization,<ref>{{cite web |url=https://www.imhro.org/research/rising-star-awards |title=International Mental Health Research Organization |publisher= |accessdate=9 June 2014 }}</ref> as well as a member of the Board of Directors of the McKnight Endowment Fund in Neuroscience.<ref name=McK>{{cite web |url=http://www.neuroscience.mcknight.org/about-us/directors |title=The McKnight Endowment Fund for Neuroscience |publisher= |accessdate=9 June 2014 }}</ref> He was elected to the [[Institute of Medicine]] in 1998 and the [[American Academy of Arts and Sciences]] in 2005.<ref name=McK/><ref>{{cite web |url=http://www.brainhealth.utdallas.edu/S=5f454f4170103281c701374298204fc5b10bfacb/about_us/team/eric-nestler-md-phd |title=Center for Brain Health |publisher= |accessdate=9 June 2014 }}</ref>


===Awards===
===Awards===
Dr. Nestler's awards and honors include the Pfizer Scholars Award (1987), the [[Sloan Fellowship|Sloan Research Fellowship]] (1987), the McKnight Scholar Award (1989), the Jordi-Folch-Pi Memorial Award from the American Society of Neurochemistry (1990), the Efron Award of the American College of Neuropsychopharmacology (1994), the Pasarow Foundation Award for Neuropsychiatric Research (1998), the NARSAD Established Investigator Award (1996), the [[Bristol-Myers Squibb]] Freedom to Discover Neuroscience Research Grant (2004), the [[Patricia Goldman-Rakic|Patricia S. Goldman-Rakic]] Award and the Falcone Prize both from NARSAD (2008, 2009), and the Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine (2010). He received an honorary doctorate from Uppsala University in Sweden in 2011.<ref>[http://asneurochem.org/History/Awards%20Recipients/FolchPirecipient1990.html American Society for Neurochemistry]</ref><ref>[http://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_bio.cfm?ID=492 The Michael J. Fox Foundation for Parkinson’s Research]</ref><ref>[http://asneurochem.org/History/PastAwardeesoftheJordiFolch-PiAward.htm Jordi Folch-Pi Awards]</ref><ref>[http://www.narsad.org/?q=node/889/latest-research NARSAD]</ref><ref>[http://www.businesswire.com/portal/site/bms/?ndmViewId=news_view&newsId=20081211006062&newsLang=en BusinessWire]</ref><ref>[http://www.newyorksocialdiary.com/node/71675 New York Social Diary]</ref>
Dr. Nestler's awards and honors include the Pfizer Scholars Award (1987), the [[Sloan Fellowship|Sloan Research Fellowship]] (1987), the McKnight Scholar Award (1989), the Jordi-Folch-Pi Memorial Award from the American Society of Neurochemistry (1990), the Efron Award of the American College of Neuropsychopharmacology (1994), the Pasarow Foundation Award for Neuropsychiatric Research (1998), the NARSAD Established Investigator Award (1996), the [[Bristol-Myers Squibb]] Freedom to Discover Neuroscience Research Grant (2004), the [[Patricia Goldman-Rakic|Patricia S. Goldman-Rakic]] Award and the Falcone Prize both from NARSAD (2008, 2009),<ref>{{cite web |url=http://bbrfoundation.org/past-outstanding-achievement-prizewinners |title=NARSAD |publisher= |accessdate=9 June 2014 }}</ref> and the Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine (2010). He received an honorary doctorate from Uppsala University in Sweden in 2011, and the Anna Monika Prize in Depression Research (2012).<ref>{{cite web |url=http://www.mpipsykl.mpg.de/1622411/10_rupprecht |title=Max Planck Intitute of Psychiatry |publisher= |accessdate=9 June 2014 }}</ref><ref>{{cite web |url=http://www.newyorksocialdiary.com/node/71675 |title=New York Social Diary |publisher= |accessdate=9 June 2014 }}</ref>

===Grants and Research===

{| class="wikitable"
|-
! Role
! Source, Title
! Identifier
|-
| Principal Investigator
| NIDA, Molecular Neurobiology of Drug Addiction<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmed/11579619 |title =NCBI |publisher= |accessdate=9 June 2014 }}</ref>
| P01 DA08227
|-
| Principal Investigator
| NIMH, Pharmacological Actions of Stress & Antidepressants Treatments<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmed/11124987 |title=NCBI |publisher= |accessdate=9 June 2014 }}</ref>
| R01 MH51399
|-
| Principal Investigator
| NIDA, Role of Neurotrophic Factors in the Actions of Drugs of Abuse<ref>{{cite web |url=http://archives.drugabuse.gov/DirReports/DirRep201/DirectorReport1.html |title=drugabuse.gov |publisher= |accessdate=9 June 2014 }}</ref>
| R01 DA14133
|-
| Principal Investigator
| NIDA, Molecular Studies of Cocaine Action in Brain<ref>{{cite web |url=http://www.labome.org/grant/k05/da/molecular/studies/molecular-studies-of-opiate-and-cocaine-action-in-brain-7188126.html |title=Labome |publisher= |accessdate=9 June 2014 }}</ref>
| R01 DA07359
|-
| Principal Investigator
| NIMH, Epigenetic Mechanisms of Depression<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmed/23020296 |title=NCBI |publisher= |accessdate=9 June 2014 }}</ref>
| P50 MH096890
|-
| Principal Investigator
| NIMH, Pharmacological Actions of Stress & Antidepressants Treatments
| R01 MH51399
|-
|}



==Publications==
==Publications==
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Partial list:
Partial list:


*Renthal W, Maze I, Krishnan V, Covington HE, Xiao GH, Kumar A, Russo SJ, Graham A, Tsankova N, Kerstetter KA, Kippin TE, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ. "Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli." Neuron 2007; 56: 517-529. PMID 17988634
*Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, Laplant Q, Cahill M, Nestler EJ, Shen L. “Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.” Genome Biol 2014; 15: R65. PMID 24758366
*Berton O, Covington HE, Ebner K, Tsankova NM, Carle TL, Ulery P, Bhonsle A, Barrot M, Krishnan V, Singewald GM, Singewald N, Birnbaum S, Neve RL, Nestler EJ. Induction of FosB in the periaqueductal gray by stress promotes active coping responses. Neuron 2007; 55: 289 -300. PMID 17640529
*Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. “G9a influences neuronal subtype specification in striatum.” Nature Neurosci 2014; 17: 533-539. PMID 24584053
*Scobie KN, Damez-Werno D, Sun H, Shao N, Gancarz A, Panganiban CH, Dias C, Koo J, Caiafa P, Kaufman L, Neve RL, Dietz DM, Shen L, Nestler EJ. “Essential role of poly(ADP-ribosyl)ation in cocaine action.” Proc Natl Acad Sci USA 2014; 111: 2005-10. PMID 24449909
*Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun HS, Scobie K, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo KM, Neve RL, Russo SJ, Han MH, Nestler EJ. “Novel role of BDNF as a negative modulator of morphine action.” Science 2012; 338: 124-128. PMID 23042896
⚫
*Vialou, V., Robison, A.J., LaPlant, Q.C., Covington, H.E. III, Dietz, D.M., Ohnishi, Y.N., Mouzon, E., Rush, A.J. III, Watts, E.L., Wallace, D.L., Iñiguez, S.D., Ohnishi, Y.H., Steiner, M.A., Warren, B., Krishnan, V., Neve, R.L., Ghose, S., Berton, O., Tamminga, C.A., and Nestler, E.J. (2010) ∆FosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature Neurosci. 13:745-752. PMID 20473292
⚫
*Maze, I., Covington, H.E. III, Dietz, D.M., LaPlant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y.H., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakovsky, A., Schaefer, A., and Nestler, E.J. (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216. PMID 20056891
⚫
*Lobo, M.K., Covington, H.E. III, Chaudhury, D., Friedman, A.K., Sun, H.S., Damez-Werno, D., Dietz, D., Zaman, S., Koo, J.W., Kennedy, P.J., Mouzon, E., Mogri, M., Neve, R.L., Deisseroth, K., Han, M.H., and Nestler, E.J. (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. {{DOI|10.1126/science.1188472}} PMID 20947769
⚫
*Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Convington, H.E. III, Mze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348. {{DOI|10.1016/j.neuron.2009.03.026}} PMID 19447090
*Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal WR, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. "The [[IRS2]]-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates." Nature Neurosci 2007; 10: 93-99. PMID 17143271
*Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal WR, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. "The [[IRS2]]-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates." Nature Neurosci 2007; 10: 93-99. PMID 17143271
*Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404. PMID 17956738
*Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchmann T, Berton O, Sim-Selley LJ, DiLeone RJ, Kumar A, Nestler EJ. "[[FOSB|FosB]]: An essential role for FosB in the nucleus accumbens in morphine action." Nature Neurosci 2006; 9: 205-211. PMID 16415864
*Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. "Sustained hippocampal chromatin regulation in hippocampus in a mouse model of depression and antidepressant action." Nature Neurosci 2006; 9: 519-525. PMID 16501568
*Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. "Sustained hippocampal chromatin regulation in hippocampus in a mouse model of depression and antidepressant action." Nature Neurosci 2006; 9: 519-525. PMID 16501568
*Berton O, McClung CA, DiLeone RJ, Krishnan V, Russo S, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. "Essential role of [[Brain-derived neurotrophic factor|BDNF]] in the mesolimbic dopamine pathway in social defeat stress." Science 2006; 311: 864-868. PMID 16469931
*Berton O, McClung CA, DiLeone RJ, Krishnan V, Russo S, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. "Essential role of [[Brain-derived neurotrophic factor|BDNF]] in the mesolimbic dopamine pathway in social defeat stress." Science 2006; 311: 864-868. PMID 16469931
⚫
*Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589. PMID 8599115
*Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814. PMID 9242609
*Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275. PMID 9856954
*Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ∆FosB in the brain controls sensitivity to cocaine. Nature 401:272-276. PMID 10499584
*McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and ∆FosB. Nature Neurosci 11:1208-1215. {{DOI|10.1038/nn1143}} PMID 14566342
*McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and ∆FosB. Nature Neurosci 11:1208-1215. {{DOI|10.1038/nn1143}} PMID 14566342
*Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., LaPlant, Q., Whistler, K., Neve, R.L., Self, D.W., and Nestler, E.J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314. PMID 16242410
*Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ∆FosB in the brain controls sensitivity to cocaine. Nature 401:272-276. PMID 10499584
*Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404. PMID 17956738
*Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275. PMID 9856954*Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814. PMID 9242609
⚫
*Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589. PMID 8599115
⚫
*Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Convington, H.E. III, Mze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348. {{DOI|10.1016/j.neuron.2009.03.026}} PMID 19447090
⚫
*Maze, I., Covington, H.E. III, Dietz, D.M., LaPlant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y.H., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakovsky, A., Schaefer, A., and Nestler, E.J. (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216. PMID 20056891
⚫
*Vialou, V., Robison, A.J., LaPlant, Q.C., Covington, H.E. III, Dietz, D.M., Ohnishi, Y.N., Mouzon, E., Rush, A.J. III, Watts, E.L., Wallace, D.L., Iñiguez, S.D., Ohnishi, Y.H., Steiner, M.A., Warren, B., Krishnan, V., Neve, R.L., Ghose, S., Berton, O., Tamminga, C.A., and Nestler, E.J. (2010) ∆FosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature Neurosci. 13:745-752. PMID 20473292
⚫
*Lobo, M.K., Covington, H.E. III, Chaudhury, D., Friedman, A.K., Sun, H.S., Damez-Werno, D., Dietz, D., Zaman, S., Koo, J.W., Kennedy, P.J., Mouzon, E., Mogri, M., Neve, R.L., Deisseroth, K., Han, M.H., and Nestler, E.J. (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. {{DOI|10.1126/science.1188472}} PMID 20947769


==References==
==References==

Revision as of 20:25, 9 June 2014

Eric J. Nestler, M.D., Ph.D., is the Nash Family Professor of Neuroscience, Chairman of the Department of Neuroscience and Director of the Friedman Brain Institute at the Mount Sinai Medical Center in New York.[1][2] His focus in neuropsychopharmacology concentrates on forming a molecular approach to psychiatry and furthering the understanding of the molecular basis of both depression and drug addiction, using animal models to study the way drug use or stress affects the brain.[1]

Nestler is the author (with Dennis S. Charney) of Neurobiology of Mental Illness (ISBN 0195189809), of Molecular Neuropharmacology (with Steven E. Hyman and Robert C. Malenka; ISBN 978-0-07-148127-4), and more than 450 chapters and peer-reviewed publications.[3] He is active in seven research projects funded by the National Institute on Drug Abuse and the National Institute of Mental Health.

Biography

Education

Nestler is a graduate of Herricks High School in New Hyde Park, New York. He received his B.A., his Ph.D. and his M.D. from Yale University. He completed his residency in psychiatry at both McLean Hospital in Massachusetts and Yale in 1987.[1]

Career

Nestler served as the Director of the Division of Molecular Psychiatry at Yale until 2000, and as Chairman of the Department of Psychiatry at the University of Texas Southwestern Medical Center at Dallas.[1] He joined Mount Sinai in 2008. He has served on the Board of Scientific Counselors of the National Institute on Drug Abuse, on the National Advisory Mental Health Council for the National Institute of Mental Health, the National Advisory Drug Abuse Council for the National Institute on Drug Abuse,[4] as Council Member of the American College of Neuropsychopharmacology (for which he served as president in 2011) and the Society for Neuroscience. He is a member of the Scientific Advisory Board of the National Alliance for Research in Schizophrenia and Depression (now known as the Brain & Behavior Research Foundation) and of the International Mental Health Research Organization,[5] as well as a member of the Board of Directors of the McKnight Endowment Fund in Neuroscience.[6] He was elected to the Institute of Medicine in 1998 and the American Academy of Arts and Sciences in 2005.[6][7]

Awards

Dr. Nestler's awards and honors include the Pfizer Scholars Award (1987), the Sloan Research Fellowship (1987), the McKnight Scholar Award (1989), the Jordi-Folch-Pi Memorial Award from the American Society of Neurochemistry (1990), the Efron Award of the American College of Neuropsychopharmacology (1994), the Pasarow Foundation Award for Neuropsychiatric Research (1998), the NARSAD Established Investigator Award (1996), the Bristol-Myers Squibb Freedom to Discover Neuroscience Research Grant (2004), the Patricia S. Goldman-Rakic Award and the Falcone Prize both from NARSAD (2008, 2009),[8] and the Rhoda and Bernard Sarnat International Prize in Mental Health from the Institute of Medicine (2010). He received an honorary doctorate from Uppsala University in Sweden in 2011, and the Anna Monika Prize in Depression Research (2012).[9][10]

Grants and Research

Role Source, Title Identifier
Principal Investigator NIDA, Molecular Neurobiology of Drug Addiction[11] P01 DA08227
Principal Investigator NIMH, Pharmacological Actions of Stress & Antidepressants Treatments[12] R01 MH51399
Principal Investigator NIDA, Role of Neurotrophic Factors in the Actions of Drugs of Abuse[13] R01 DA14133
Principal Investigator NIDA, Molecular Studies of Cocaine Action in Brain[14] R01 DA07359
Principal Investigator NIMH, Epigenetic Mechanisms of Depression[15] P50 MH096890
Principal Investigator NIMH, Pharmacological Actions of Stress & Antidepressants Treatments R01 MH51399


Publications

Partial list:

  • Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, Laplant Q, Cahill M, Nestler EJ, Shen L. “Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.” Genome Biol 2014; 15: R65. PMID 24758366
  • Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. “G9a influences neuronal subtype specification in striatum.” Nature Neurosci 2014; 17: 533-539. PMID 24584053
  • Scobie KN, Damez-Werno D, Sun H, Shao N, Gancarz A, Panganiban CH, Dias C, Koo J, Caiafa P, Kaufman L, Neve RL, Dietz DM, Shen L, Nestler EJ. “Essential role of poly(ADP-ribosyl)ation in cocaine action.” Proc Natl Acad Sci USA 2014; 111: 2005-10. PMID 24449909
  • Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun HS, Scobie K, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo KM, Neve RL, Russo SJ, Han MH, Nestler EJ. “Novel role of BDNF as a negative modulator of morphine action.” Science 2012; 338: 124-128. PMID 23042896
  • Vialou, V., Robison, A.J., LaPlant, Q.C., Covington, H.E. III, Dietz, D.M., Ohnishi, Y.N., Mouzon, E., Rush, A.J. III, Watts, E.L., Wallace, D.L., Iñiguez, S.D., Ohnishi, Y.H., Steiner, M.A., Warren, B., Krishnan, V., Neve, R.L., Ghose, S., Berton, O., Tamminga, C.A., and Nestler, E.J. (2010) ∆FosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature Neurosci. 13:745-752. PMID 20473292
  • Maze, I., Covington, H.E. III, Dietz, D.M., LaPlant, Q., Renthal, W., Russo, S.J., Mechanic, M., Mouzon, E., Neve, R.L., Haggarty, S.J., Ren, Y.H., Sampath, S.C., Hurd, Y.L., Greengard, P., Tarakovsky, A., Schaefer, A., and Nestler, E.J. (2010) Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 327:213-216. PMID 20056891
  • Lobo, M.K., Covington, H.E. III, Chaudhury, D., Friedman, A.K., Sun, H.S., Damez-Werno, D., Dietz, D., Zaman, S., Koo, J.W., Kennedy, P.J., Mouzon, E., Mogri, M., Neve, R.L., Deisseroth, K., Han, M.H., and Nestler, E.J. (2010) Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. doi:10.1126/science.1188472 PMID 20947769
  • Renthal, W., Kumar, A., Xiao, G.H., Wilkinson, M., Convington, H.E. III, Mze, I., Sikder, D., Robison, A.J., LaPlant, Q., Dietz, D.M., Russo, S.J., Vialou, V., Chakravarty, S., Kodadek, T.J., Stack, A., Kabbaj, M., and Nestler, E.J. (2009) Genome wide analysis of chromatin regulation by cocaine reveals a novel role for sirtuins. Neuron 62:335-348. doi:10.1016/j.neuron.2009.03.026 PMID 19447090
  • Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal WR, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. "The IRS2-Akt pathway in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates." Nature Neurosci 2007; 10: 93-99. PMID 17143271
  • Krishnan, V., Han, M.-H., Graham, D.L., Berton, O., Renthal, W., Russo, S.J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D.C., Ghose, S., Reister, R., Tannous, P., Green, T.A., Neve, R.L., Chakravarty, S., Kumar, A., Eisch, A.J., Self, D.W., Lee, F.S., Tamminga, C.A., Cooper, D.C., Gershenfeld, H.K., and Nestler, E.J. (2007) Susceptibility and resistance to social defeat are mediated through molecular adaptations in brain reward regions. Cell 131:391-404. PMID 17956738
  • Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. "Sustained hippocampal chromatin regulation in hippocampus in a mouse model of depression and antidepressant action." Nature Neurosci 2006; 9: 519-525. PMID 16501568
  • Berton O, McClung CA, DiLeone RJ, Krishnan V, Russo S, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. "Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress." Science 2006; 311: 864-868. PMID 16469931
  • McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and ∆FosB. Nature Neurosci 11:1208-1215. doi:10.1038/nn1143 PMID 14566342
  • Kelz, M.B., Chen, J.S., Carlezon, W.A., Whisler, K., Gilden, L., Beckmann, A.M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D.W., Tkatch, R., Baranauskas, G., Surmeier, D.J., Neve, R.L., Duman, R.S., Picciotto, M.R., and Nestler, E.J. (1999) Expression of the transcription factor ∆FosB in the brain controls sensitivity to cocaine. Nature 401:272-276. PMID 10499584
  • Carlezon, W.A., Jr., Thome, J., Olson, V.G., Lane-Ladd, S.B., Brodkin, E.S., Hiroi, N., Duman, R.S., Neve, R.L., and Nestler, E.J. (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275. PMID 9856954*Carlezon, W.A., Jr., Boundy, V.A., Haile, C.N., Kalb, R.G., Neve, R., and Nestler, E.J. (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814. PMID 9242609
  • Self, D.W., Barnhart, W.J., Lehman, D.A., and Nestler, E.J. (1996) Opposite modulation of cocaine-seeking behavior by D1-like and D2-like dopamine receptor agonists. Science 271:1586-1589. PMID 8599115

References

  1. ^ a b c d "Mount Sinai Hospital Doctor Profile". Retrieved 9 June 2014.
  2. ^ "McGraw Hill Medical". Retrieved 9 June 2014.
  3. ^ "PubMed". National Institutes of Health. Retrieved 9 June 2014.
  4. ^ "National Institute on Drug Abuse". Retrieved 9 June 2014.]
  5. ^ "International Mental Health Research Organization". Retrieved 9 June 2014.
  6. ^ a b "The McKnight Endowment Fund for Neuroscience". Retrieved 9 June 2014.
  7. ^ "Center for Brain Health". Retrieved 9 June 2014.
  8. ^ "NARSAD". Retrieved 9 June 2014.
  9. ^ "Max Planck Intitute of Psychiatry". Retrieved 9 June 2014.
  10. ^ "New York Social Diary". Retrieved 9 June 2014.
  11. ^ "NCBI". Retrieved 9 June 2014.
  12. ^ "NCBI". Retrieved 9 June 2014.
  13. ^ "drugabuse.gov". Retrieved 9 June 2014.
  14. ^ "Labome". Retrieved 9 June 2014.
  15. ^ "NCBI". Retrieved 9 June 2014.

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