Talk:Glutamine

FIX NEEDED

The 3-D model of glutamine on this page is wrong. Would somebody please fix it? It's showing two carboxylic acid groups, rather than an amide!

Note

I've modified this:

In people living with diseases that put long term strain on the immune system (like HIV), glutamine is burned at a higher rate. Glutamine is also used in the digestive process and -- if not supplemented -- can lead to wasting.

Glutamine may have something to do with cachexia, but the relationship between the two things is certainly not as simple as this implies. It would be nice to be able to quote a reference here. -- Someone else 02:52 Apr 12, 2003 (UTC)

Theraputic uses of glutamine

My wife, who has undergone radiation treatment to her abdominal area and is now suffering from radiation enteritis, was told by her physician that glutamine supplementation has been shown to help heal the villi lining the bowel. My subsequent reading on the web has indicated this to be a commonly accepted treatment regimen for people with radiation enteritis, irritable bowel disease, or other similar problems. Glutamine also is prescribed to HIV patients, and to patients receiving radiation and chemotherapy. -- unsigned

Adverse effects

This article concentrates on adverse effects of glutamine consumption. However, it gives zero references. This article desperately needs some work in this area. In particular, someone who knows this stuff needs to firm up the documentation. I'm not a biochemist, so I don't know how much of this information is well-supported and how much is hearsay. Gwimpey 05:59, Apr 14, 2005 (UTC)

OK, most of this page was a copyvio. I removed the offending material and put a link to the source Gwimpey 06:18, Apr 14, 2005 (UTC)

From PNA/Biology

• Glutamine talks about all sorts of negative effects of the compound, but gives no references. Also, would be good to have information on biochemical role (it is one of the 20-odd amino acids that compose proteins). Gwimpey 06:03, Apr 14, 2005 (UTC)

Rewrite

Since very little of relevance was left, I went ahead and rewrote the article. It could still use more help (as could a lot of the other amino acid articles-- I may get around to this). In particular, I removed this:

It is converted into the excitotoxin glutamate within neurons. Glutamine is then transported to the neuron and by the enzyme glutaminase, it is converted to glutamate--the potential excitotoxin. Unless it accumulates outside the brain cell it is harmless.

While arguably true, this tends to create the impression that glutamine is notable as a neurotoxin, which is false. Molybdenumblue 23:52, 16 Apr 2005 (UTC)

WPN Ello there everyone - Spum here from WikiProject Nutrition, i'm just going to be adding some information to this article, as well as grouping it under WikiProject Nutriition (and dietetics). If you want to help, you are more than welcome to join the project. Spum 17:43, 14 December 2005 (UTC)

competition with creatine for absorbtion

Is there any truth to the claim that glutamine competes with creatine for absorption? -- Sy / ^(talk) 00:33, 25 March 2007 (UTC)

I guess this is a myth.. [1]

Myth: "Don't take your creatine with protein because protein contains glutamine and glutamine competes with creatine for the same transporter!"

The Real Deal: There's not an ounce of truth to this. Creatine and glutamine have completely different receptors. Creatine transport into skeletal muscle is regulated by the Creatine Transporter7 while glutamine transport into skeletal muscle is regulated by a system known as "System Nm." 8 The only thing these transporters have in common is that they are both sodium-dependent transporters, meaning that they use differences in sodium concentrations across the cell membrane to drive creatine into cells. Apparently somewhere along the line, somebody believed that since glutamine and creatine transporters both shared that characteristic, they must be the same transporter and the myth spread from there. Let the confusion end here: they do not share the same transporter, and taking protein/glutamine with creatine won't decrease creatine uptake into muscle.

On the subject of raw vs cooked glutamine

May I please ask what is wrong with the idea of indicating on this page that cooked food contains no glutamine useful to the human body? I've attempted three times now to add this to the document only to find it reverted because the references weren't quite kosher. One only needs to google for "glutamine cooked OR cooking" to see that just about ever page on this subject indicates that cooking destroys glutamine. The last time I changed the page, it wasn't simply reverted, but ALL references to raw food were removed. Even ones I didn't add.

I can understand that from a scientific viewpoint, the glutamine might not actually be destroyed by cooking, but cooking removes 100% of glutamines usefulness to the human body, and this is a page about nutrition right? CrazyEddy (talk) 13:13, 18 November 2007 (UTC)