Methoxyflurane: Difference between revisions

Methoxyflurane
Clinical data
Other names	2,2-dichloro-1,1-difluoroethyl methyl ether
Routes of; administration	Inhalation
ATC code	N01AB03 (WHO) ;
Identifiers
	IUPAC name 2,2-dichloro-1,1-difluoro-1-methoxy-ethane;
CAS Number	76-38-0;
PubChem CID	4116;
DrugBank	APRD00744;
CompTox Dashboard (EPA)	DTXSID7025556 ;
ECHA InfoCard	100.000.870
Chemical and physical data
Formula	C3H4Cl2F2O
Molar mass	164.965 g/mol g·mol−1

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 17:40, 12 January 2009

Methoxyflurane (C₃H₄Cl₂F₂O) is an inhalational anaesthetic used in the 1960s and early 1970s, but withdrawn because of detrimental effects on the kidneys. This was due to fluoride ions being produced by its metabolism in the kidney. (This effect was considered to be dose-dependent, smaller doses for shorter periods being considered relatively safer).

Its minimum alveolar concentration (MAC) is 0.2, hence it is extremely potent. It has a high lipid solubility (oil:gas coefficient around 950) giving it a very slow onset/offset, this being undesirable for anesthetic purposes.

Even so, methoxyflurane is a powerful analgesic (pain-relieving) agent, at well below full anaesthetic doses. The vapour is sometimes said to have a pleasant, fruity aroma.

Methoxyflurane is used extensively in Australian ambulance services as an emergency analgesic.

External links

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

@@ Line 32: / Line 32: @@
 Even so, methoxyflurane is a powerful analgesic (pain-relieving) agent, at well below full anaesthetic doses. The vapour is sometimes said to have a pleasant, fruity aroma.
-Methoxyflurane is used extensively in Australian ambulance services, and in [[St John Ambulance]] as an emergency [[analgesic]].
+Methoxyflurane is used extensively in Australian ambulance services as an emergency [[analgesic]].
 ==External links==