Talk:Naphyrone

Article name

O-2482 is typical of a label initially given to a new compound before it gains a name. I don't see it being used beyond the initial research paper. I think NRG-1 or naphyrone would be more appropriate, and there should be some more sources appearing over the next few days to help us decide. --Pontificalibus (talk) 14:27, 2 April 2010 (UTC)

Naphyrone seems like it would be best IMO. NRG-1 would seem to be a brand name. Smartse (talk) 20:48, 2 April 2010 (UTC)

Why does NRG-1 redirect here? It's the name of a legal high sold online, not identified as naphyrone and only suspected to be such. Adenylated (talk) 02:50, 15 May 2010 (UTC)

The sources in the article identify it as such --Pontificalibus (talk) 07:54, 15 May 2010 (UTC)

Pharmacology

This data is from the paper cited:

• DAT Ki(nM) = 20.1±7.1
• D uptake(IC50) = 40.0±13
• DRb = 1.99
• SERT Ki(nM) = 33.1±1.1
• SER uptake(IC50) = 46.0±5.5
• NET Ki(nM) = 136±27
• NE uptake(IC50) = 11.7±0.9

Other info: One notable exception to this selectivity is the naphthyl analogue 4t, which binds to all three transporters and inhibits reuptake at the nanomolar potency range. Only two compounds (4t and 4u) manifested SERT Ki values of <200 nM. The naphthyl analogue 4t inhibited SERTs with modest potency (Ki = 33.1 nM), and the high lipophilicity of this compound (c log P = 4.77) may be partially responsible for this potency. However, the lipophilic dichlorophenyl analogue 4u (c log P = 5.01) manifested a lesser SERT potency (Ki = 199 nM). Therefore, lipophilicity was likely not the only factor that determined the potency for 4t. Two compounds (4o, which was a selective DAT inhibitor and 4t, which had similar potency at the DAT and SERT) were selected for evaluation of locomotor activity. Both manifested a time- and dose-dependent stimulation of locomotor activity (ED50 = 0.21 mg/kg and 2.2 mg/kg, respectively) with a duration of action of >8 h.

I would add this info to the article but my knowledge of pharmacology is crap so it would be better if someone else could digest this and turn it into something that people might understand. It sounds like a pretty unusual compound... Smartse (talk) 11:08, 5 April 2010 (UTC)

Dosage

This page needs some information on dosage as well as references to support this, maybe from erowid or elsewhere, the chemical is highly dangerous when taken wrecklessly without first knowing the low doses which it must be taken in to avoid adverse effects. —Preceding unsigned comment added by 92.4.129.158 (talk) 16:31, 4 May 2010 (UTC)

Legal status

I added in the results of a recent batch analysis that highlighted at least one sample of what was labelled NRG-1 actually contained MDPV, which is a Class B substance. However I am not sure if the tone of my addition is encyclopeadic enough, and I am doing this at work so don't have time to labour over the language I used- so if someone wants to improve on my efforts feel free!Rednotdead (talk) 13:35, 18 June 2010 (UTC)