Jump to content

PPP1R15A: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m Citations: [Pu184]Tweaked: doi. You can use this bot yourself. Report bugs here.
Fix refs and minor fixes using AWB
Line 4: Line 4:
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =
| section_title =
| summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23645| accessdate = }}</ref>
| summary_text = This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.<ref name="entrez"/>
}}
}}


==Interactions==
==Interactions==
PPP1R15A has been shown to [[Protein-protein_interaction|interact]] with [[PPP1CB]],<ref name=pmid12016208>{{cite journal |last=Wu |first=Daniel Y |authorlink= |coauthors=Tkachuck Douglas C, Roberson Rachel S, Schubach William H |year=[[2002]]|month=Aug. |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 |publisher= |location = United States| issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11564868>{{cite journal |last=Connor |first=J H |authorlink= |coauthors=Weiser D C, Li S, Hallenbeck J M, Shenolikar S |year=[[2001]]|month=Oct. |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 |publisher= |location = United States| issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99861 }}</ref> [[PPP1CA]],<ref name=pmid12724406>{{cite journal |doi=10.1128/MCB.23.10.3477-3486.2003 |last=Hung |first=Wesley J |authorlink= |coauthors=Roberson Rachel S, Taft Jaime, Wu Daniel Y |year=[[2003]]|month=May. |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions |journal=Mol. Cell. Biol. |volume=23 |issue=10 |pages=3477–86 |publisher= |location = United States| issn = 0270-7306| pmid = 12724406 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=164759 }}</ref><ref name=pmid12016208/><ref name=pmid11564868/> [[PPP1CC]],<ref name=pmid12016208/><ref name=pmid11564868/> [[SMARCB1]],<ref name=pmid10490642>{{cite journal |last=Adler |first=H T |authorlink= |coauthors=Chinery R, Wu D Y, Kussick S J, Payne J M, Fornace A J, Tkachuk D C |year=[[1999]]|month=Oct. |title=Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins |journal=Mol. Cell. Biol. |volume=19 |issue=10 |pages=7050–60 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10490642 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84700 }}</ref><ref name=pmid12016208/> [[LYN]],<ref name=pmid11517336>{{cite journal |last=Grishin |first=A V |authorlink= |coauthors=Azhipa O, Semenov I, Corey S J |year=[[2001]]|month=Aug. |title=Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=18 |pages=10172–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11517336 |doi = 10.1073/pnas.191130798 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=56934 }}</ref> [[TSN (gene)|TSN]],<ref name=pmid10434033>{{cite journal |last=Hasegawa |first=T |authorlink= |coauthors=Isobe K |year=[[1999]]|month=Aug. |title=Evidence for the interaction between Translin and GADD34 in mammalian cells |journal=Biochim. Biophys. Acta |volume=1428 |issue=2-3 |pages=161–8 |publisher= |location = NETHERLANDS| issn = 0006-3002| pmid = 10434033 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BAG1]]<ref name=pmid12724406/> and [[MLL (gene)|MLL]].<ref name=pmid10490642/>
PPP1R15A has been shown to [[Protein-protein interaction|interact]] with [[PPP1CB]],<ref name=pmid12016208>{{cite journal |last=Wu |first=Daniel Y |authorlink= |coauthors=Tkachuck Douglas C, Roberson Rachel S, Schubach William H |year=[[2002]]|month=Aug. |title=The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27706–15 |publisher= |location = United States| issn = 0021-9258| pmid = 12016208 |doi = 10.1074/jbc.M200955200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11564868>{{cite journal |last=Connor |first=J H |authorlink= |coauthors=Weiser D C, Li S, Hallenbeck J M, Shenolikar S |year=[[2001]]|month=Oct. |title=Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 |journal=Mol. Cell. Biol. |volume=21 |issue=20 |pages=6841–50 |publisher= |location = United States| issn = 0270-7306| pmid = 11564868 |doi = 10.1128/MCB.21.20.6841-6850.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99861 }}</ref> [[PPP1CA]],<ref name=pmid12016208/><ref name=pmid11564868/><ref name=pmid12724406>{{cite journal |doi=10.1128/MCB.23.10.3477-3486.2003 |last=Hung |first=Wesley J |authorlink= |coauthors=Roberson Rachel S, Taft Jaime, Wu Daniel Y |year=[[2003]]|month=May. |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions |journal=Mol. Cell. Biol. |volume=23 |issue=10 |pages=3477–86 |publisher= |location = United States| issn = 0270-7306| pmid = 12724406 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=164759 }}</ref> [[PPP1CC]],<ref name=pmid12016208/><ref name=pmid11564868/> [[SMARCB1]],<ref name=pmid12016208/><ref name=pmid10490642>{{cite journal |last=Adler |first=H T |authorlink= |coauthors=Chinery R, Wu D Y, Kussick S J, Payne J M, Fornace A J, Tkachuk D C |year=[[1999]]|month=Oct. |title=Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins |journal=Mol. Cell. Biol. |volume=19 |issue=10 |pages=7050–60 |publisher= |location = United States| issn = 0270-7306| pmid = 10490642 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84700 }}</ref> [[LYN]],<ref name=pmid11517336>{{cite journal |last=Grishin |first=A V |authorlink= |coauthors=Azhipa O, Semenov I, Corey S J |year=[[2001]]|month=Aug. |title=Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=18 |pages=10172–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11517336 |doi = 10.1073/pnas.191130798 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=56934 }}</ref> [[TSN (gene)|TSN]],<ref name=pmid10434033>{{cite journal |last=Hasegawa |first=T |authorlink= |coauthors=Isobe K |year=[[1999]]|month=Aug. |title=Evidence for the interaction between Translin and GADD34 in mammalian cells |journal=Biochim. Biophys. Acta |volume=1428 |issue=2-3 |pages=161–8 |publisher= |location = NETHERLANDS| issn = 0006-3002| pmid = 10434033 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BAG1]]<ref name=pmid12724406/> and [[MLL (gene)|MLL]].<ref name=pmid10490642/>


==References==
==References==
{{reflist}}
{{Reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB_Further_reading
| citations =
| citations =
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
Line 37: Line 38:
}}
}}
{{refend}}
{{refend}}

⚫
{{gene-19-stub}}


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
{{PBB_Controls
| update_page = yes
| update_page = yes
| require_manual_inspection = no
| require_manual_inspection = no
| update_protein_box = yes
| update_protein_box = yes
| update_summary = yes
| update_summary = yes
| update_citations = yes
| update_citations = yes
}}
}}


⚫
{{Gene-19-stub}}

Revision as of 14:38, 14 November 2011

Template:PBB Protein phosphatase 1 regulatory subunit 15A is an enzyme that in humans is encoded by the PPP1R15A gene.[1][2][3]

Template:PBB Summary

Interactions

PPP1R15A has been shown to interact with PPP1CB,[4][5] PPP1CA,[4][5][6] PPP1CC,[4][5] SMARCB1,[4][7] LYN,[8] TSN,[9] BAG1[6] and MLL.[7]

References

  1. ^ Hollander MC, Zhan Q, Bae I, Fornace AJ Jr (1997). "Mammalian GADD34, an apoptosis- and DNA damage-inducible gene". J Biol Chem. 272 (21): 13731–7. doi:10.1074/jbc.272.21.13731. PMID 9153226. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Korabiowska M, Betke H, Kellner S, Stachura J, Schauer A (1998). "Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas". Anticancer Res. 17 (5A): 3697–700. PMID 9413226. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A".
  4. ^ a b c d Wu, Daniel Y (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  5. ^ a b c Connor, J H (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  6. ^ a b Hung, Wesley J (2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. 23 (10). United States: 3477–86. doi:10.1128/MCB.23.10.3477-3486.2003. ISSN 0270-7306. PMC 164759. PMID 12724406. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  7. ^ a b Adler, H T (1999). "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins". Mol. Cell. Biol. 19 (10). United States: 7050–60. ISSN 0270-7306. PMC 84700. PMID 10490642. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  8. ^ Grishin, A V (2001). "Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18). United States: 10172–7. doi:10.1073/pnas.191130798. ISSN 0027-8424. PMC 56934. PMID 11517336. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  9. ^ Hasegawa, T (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochim. Biophys. Acta. 1428 (2–3). NETHERLANDS: 161–8. ISSN 0006-3002. PMID 10434033. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)

Further reading

Template:PBB Further reading

Template:PBB Controls


Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=PPP1R15A&oldid=460612183"