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Protein PPP1CB PDB 1s70.png
Aliases PPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta
External IDs MGI: 104871 HomoloGene: 37659 GeneCards: PPP1CB
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 28.75 – 28.8 Mb Chr 5: 32.46 – 32.52 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.[3]

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[4]


PPP1CB has been shown to interact with PPP1R15A,[5][6] Nucleolin,[7] SMARCB1[5] and PPP1R9B.[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)". Biochim Biophys Acta. 1220 (2): 212–8. doi:10.1016/0167-4889(94)90138-4. PMID 8312365. 
  4. ^ "Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform". 
  5. ^ a b Wu, Daniel Y; Tkachuck Douglas C; Roberson Rachel S; Schubach William H (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. United States. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208. 
  6. ^ Connor, J H; Weiser D C; Li S; Hallenbeck J M; Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. United States. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861Freely accessible. PMID 11564868. 
  7. ^ Morimoto, Hiroyuki; Okamura Hirohiko; Haneji Tatsuji (September 2002). "Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells". J. Histochem. Cytochem. United States. 50 (9): 1187–93. doi:10.1177/002215540205000905. ISSN 0022-1554. PMID 12185196. 
  8. ^ Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. UNITED STATES. 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355. 

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