Pancreatic polypeptide: Difference between revisions
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Its secretion in humans is increased after a protein meal, fasting, exercise, and acute [[hypoglycemia]] and is decreased by [[somatostatin]] and intravenous [[glucose]]. |
Its secretion in humans is increased after a protein meal, fasting, exercise, and acute [[hypoglycemia]] and is decreased by [[somatostatin]] and intravenous [[glucose]]. |
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Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition peripheral administration of PP has been shown to decrease food intake in rodents. <ref>http://jcem.endojournals.org/content/88/8/3989.abstract</ref> |
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==References== |
==References== |
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Revision as of 06:24, 30 March 2012
| pancreatic polypeptide | |||||||
|---|---|---|---|---|---|---|---|
 IHC for Pancreatic Polypeptide in a mouse pancreas, 200x. | |||||||
| Identifiers | |||||||
| Symbol | PPY | ||||||
| NCBI gene | 5539 | ||||||
| HGNC | 9327 | ||||||
| OMIM | 167780 | ||||||
| RefSeq | NM_002722 | ||||||
| UniProt | P01298 | ||||||
| Other data | |||||||
| Locus | Chr. 17 p11.1-qter | ||||||
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Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.[1]
The function of PP is to self regulate the pancreas secretion activities (endocrine and exocrine), it also has effects on hepatic glycogen levels and gastrointestinal secretions.
Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.
Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition peripheral administration of PP has been shown to decrease food intake in rodents. [2]
References
- ^ Lonovics J, Devitt P, Watson LC, Rayford PL, Thompson JC (1981 Oct). "Pancreatic polypeptide". Arch Surg. 116 (10): 1256–64. PMID 7025798.
{{cite journal}}: Check date values in:|year=(help)CS1 maint: multiple names: authors list (link) CS1 maint: year (link) - ^ http://jcem.endojournals.org/content/88/8/3989.abstract
External links
- Template:GeorgiaPhysiology
- Pancreatic+polypeptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- BBC Hope over 'obesity-busting gum' 15 January 2007
 | This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it. |