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'''Arieh Warshel''' is a Distinguished Professor of Chemistry and Biochemistry at the [[University of Southern California]].
'''Arieh Warshel''' is a Distinguished Professor of Chemistry and Biochemistry at the [[University of Southern California]]. He received the 2013 [[Nobel Prize]] in Chemistry, together with [[Michael Levitt]] and [[Martin Karplus]] for "the development of multiscale models for complex chemical systems". <ref>{{cite press release
| title = The Nobel Prize in Chemistry 2013
| publisher = Royal Swedish Academy of Sciences
| date = October 09, 2013
| language = English
| url = http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2013/press.pdf
| accessdate = October 09, 2013}}</ref>


==Biography==
==Biography==

Revision as of 10:06, 9 October 2013

Arieh Warshel
BornNovember 20th 1940
Kibbutz Sde-Nahum, Israel
Known forComputer simulation, Computational enzymology, electrostatics, enzyme catalysis
Scientific career
FieldsChemistry, Biochemistry, Biophysics
InstitutionsUniversity of Southern California

Arieh Warshel is a Distinguished Professor of Chemistry and Biochemistry at the University of Southern California. He received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Martin Karplus for "the development of multiscale models for complex chemical systems". [1]

Biography

Born in 1940 in Kibbutz Sde Nahum, Israel, and after serving the Israeli Army (final rank Captain), Warshel attended the Technion, Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. Subsequently, he earned both MSc and PhD degrees in Chemical Physics (in 1967 and 1969, respectively), with Shneior Lifson, Weizmann Institute of Science, Israel. After his PhD, he did postdoctoral work at Harvard University, from 1972 to 1976 he returned to the Weizmann Institute and worked for the Laboratory of Molecular Biology, Cambridge, England. In 1976 he joined the faculty of the Department of Chemistry at USC. He won the 2013 Nobel Prize in Chemistry.

Honors and Awards

Arieh Warshel is known for his work on computational biochemistry and biophysics, in particular for pioneering computer simulations of the functions of biological systems, and for developing what is known today as Computational Enzymology.[2] He is member of many scientific organisations, most importantly

and he has been awarded on many occasions for his efforts:

  • Annual Award of the International Society of Quantum Biology and Pharmacology (1993) [7]
  • Tolman Medal (2003) [8]
  • President’s award for computational biology from the ISQBP (2006) [9]
  • RSC Soft Matter and Biophysical Chemistry Award (2012) [2]
  • Nobel Prize in Chemistry (2013) together with Martin Karplus and Michael Levitt for "for the development of multiscale models for complex chemical systems". [10]

Major Research Achievements

Arieh Warshel made major contributions in introducing computational methods for structure function correlation of biological molecules, pioneering and co-pioneering programs, methods and key concepts for detailed computational studies of functional properties of biological molecules including Cartesian-based force field programs,[11][12] the QM/MM method for simulating enzymatic reactions,[13] the first molecular dynamic simulation of a biological process,[14][15] microscopic electrostatic models for proteins,[16] free energy perturbation in proteins [17] and other key advances. It was for the development of these methods that Warshel shared the 2013 Nobel Prize in Chemistry. [18]

References

  1. ^ "The Nobel Prize in Chemistry 2013" (PDF) (Press release). Royal Swedish Academy of Sciences. October 09, 2013. Retrieved October 09, 2013. {{cite press release}}: Check date values in: |accessdate= and |date= (help)
  2. ^ a b http://www.rsc.org/ScienceAndTechnology/Awards/SoftMatterBiophysicalChemistryAward/2012-Winner.asp
  3. ^ http://dornsife.usc.edu/news/stories/558/arieh-warshel-elected-to-the-national-academy-of-sciences/
  4. ^ http://dornsife.usc.edu/news/stories/539/arieh-warshel-elected-to-royal-society-of-chemistry/
  5. ^ http://www.biophysics.org/AwardsOpportunities/SocietyAwards/FellowoftheBiophysicalSocietyAward/tabid/501/Default.aspx
  6. ^ http://www.sloan.org/sloan-research-fellowships/past-fellows/
  7. ^ http://isqbp.umaryland.edu/ISQBP/People.htm
  8. ^ http://scalacs.org/?page_id=20
  9. ^ isqbp.umaryland.edu/ISQBP/newsletters/ISQBP_aug06.pdf
  10. ^ http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2013/press.pdf
  11. ^ Lifson S, Warshel A. (1968). "A Consistent Force Field for Calculation on Conformations, Vibrational Spectra and Enthalpies of Cycloalkanes and n-Alkane Molecules". J. Phys. Chem. 49 (11): 5116. doi:10.1063/1.1670007.
  12. ^ Warshel A, Lifson S. (1970). "Consistent Force Field Calculations. II. Crystal Structure, Sublimation Energies, Molecular and Lattice Vibrations, Molecular Conformations and Enthalpies of Alkanes". J. Chem. Phys. 53 (2): 582. doi:10.1063/1.1674031.
  13. ^ Warshel A, Levitt M (1976). "Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme". J. Mol. Biol. 103 (2): 227–249. doi:10.1016/0022-2836(76)90311-9. PMID 985660.
  14. ^ Warshel A. (1976). "Bicycle-pedal Model for the First Step in the Vision Process". Nature. 260 (5553): 679–683. doi:10.1038/260679a0. PMID 1264239.
  15. ^ Warshel A. (2002). "Molecular Dynamics Simulations of Biological Reactions". Acc. Chem. Res. 35 (6): 385–395. doi:10.1021/ar010033z. PMID 12069623.
  16. ^ Warshel A., Russel T. (1984). "Calculations of electrostatic interactions in biological systems and in solutions". Q.Rev.Biophys. 17: 283–421.
  17. ^ Warshel A (1984). "Simulating the Energetics and Dynamics of Enzymatic Reactions". Pontificiae Academiae Scientiarum Scripta Varia. 55: 60.
  18. ^ http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2013/press.pdf

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