Talk:Finasteride

Post-Finasteride Syndrome

The Post-Finasteride Syndrome should also added to the side effects of finasteride.

That depends on Wikipedia:Articles for deletion/Post-Finasteride Syndrome, in my opinion. Biosthmors (talk) 16:05, 4 October 2012 (UTC)

So, I would now like to see if the admins here are also so fast in changing this entry, on the AS than on the dicusion about the deletion. of the post-finasteride syndrome. Everbody, who wonders, why the article has been deleted can read all here Wo is still want to read the article about the post-finasteride syndrome, can find it here.--Brainbug666 (talk) 00:13, 11 October 2012 (UTC)

DHT

Seems to be a contidiction?? at start:"converts testosterone to dihydrotestosterone" (DHT) near bottom of article states: works "By blocking DHT production" which is correct?? Davidrogerc (talk) 02:50, 19 November 2012 (UTC)davidrogerc

See the next section. Adrian J. Hunter^{(talk•contribs)} 11:15, 2 January 2013 (UTC)

Edit request on 2 January 2013

The line "This enzyme converts testosterone to dihydrotestosterone (DHT). " is wrong & is supposed to be "This enzyme PREVENTS conversion of..."

Hope you change it or allow me.

Zoeyetra (talk) 03:35, 2 January 2013 (UTC)

The enzyme 5α-reductase does the conversion. Finasteride inhibits the enzyme, thus preventing the conversion. I've reworded the lead for clarity. The wording is a bit awkward but it retains the highly relevant wikilinks. Adrian J. Hunter^{(talk•contribs)} 11:15, 2 January 2013 (UTC)

Edit request on 3 January 2013

Please add the following to the "History" section: Dr. Reddy’s Laboratories announced today that is has launched Finasteride Tablets (1 mg), a bioequivalent generic version of Propecia® (Finasteride) Tablets in the US market on January 02, 2013. Dr. Reddy’s ANDA for Finasteride 1 mg Tablets has been awarded a 180-day period of marketing exclusivity in the U.S. on 2 Jan, 2013.

Digitalpharmacist (talk) 14:36, 3 January 2013 (UTC)

Not done: mainly because the source provided is a wiki and a press release. Also the proposed text reads like a press release. Please provide reliable, third-party sources to support this claim and reword the proposed text to an encyclopedic tone and I might be willing to entertain this request. —KuyaBriBri^Talk 15:38, 3 January 2013 (UTC)

Jenny McCarthy

On the Howard Stern show Jenny McCarthy claimed that propecia has the side effcts of erectile disfunction. http://howardstern.com/ (go to wensday's show, March 13, 2013) I think its an interesting bit of information for the article, adding a cultural dimension. — Preceding unsigned comment added by 97.107.215.232 (talk) 08:01, 15 March 2013 (UTC)

It is already discussed in extenso. Jenny McCarthy is not a medical authority. JFW | T@lk 21:52, 17 March 2013 (UTC)

Edit request

Merck warned about persistent Finasteride side effects in the early 1990's on the Proscar label. This means they showed up in the clinical trials. The article as it currently is indicates that only Internet hysteria caused a wave of post-marketing case reports, mandating a label change. When in fact, side effects that persist after discontinuation was first on the label nearly two decades ago. The warning was only omitted on one Finasteride brand (Propecia). The Australian Financial Review mentioned this in a piece on finasteride. — Preceding unsigned comment added by Gilmour1201 (talk • contribs)

As I explained on your talk page, this cannot be discussed without a WP:MEDRS-compatible secondary source. JFW | T@lk 11:53, 20 February 2014 (UTC)

Both labels have been cited. The reader can verify the incongruity. — Preceding unsigned comment added by Gilmour1201 (talk • contribs) 08:28, 21 February 2014 (UTC)

JfdWolff, you can even read the label in your native tongue. See the Dutch label warning of persistent side effects here.

ETA: Copy and Paste if the linke won't work from Wikipedia.

http://www.dokteronline.com/pils/nl/patient_information_leaflet-760-proscar_5_mg,_filmomhulde_tabletten-nl.pdf-1326804181.pdf

"Als de verschijnselen bleven aanhouden, verdwenen ze meestal bij het stopzetten van de inname van PROSCAR."

Gilmour1201 The situation hasn't changed. You are engaging in investigative journalism rather than writing an encyclopedia. There is already a section that discusses very clearly the nature of sexual AEs and the fact that they might persist. You are now adding some weak sources (that definitely fail WP:MEDRS) to suggest that the package inserts didn't always discuss this side effect. The only benefit that I can see is an implied accusation of bad faith on behalf of the manufacturer. For such a claim you need very strong sources, quite the opposite of what you're doing. :::I really think you should have a look at dispute resolution rather than repeatedly adding the same stuff. Alternatively, you could try the reliable sources noticeboard to see whether the community has particular views on the quality of your sources. Good luck. JFW | T@lk 12:31, 21 February 2014 (UTC)

JDWolff , your latest post is so absurd I don't even know where to begin. You say, "there is already a section that discusses very clearly the nature of sexual AE's and the fact that they might persist." I already told you why an addendum is necessary. The article as is indicates that ONLY POST-MARKETING CASE REPORTS of persistent sexual AE's have been reported. But not only was persistent side effects warned about when Proscar hit the market, but persistent AE's were also picked up in the PLESS trials.

"You are now adding some weak sources (that definitely fail WP:MEDRS) to suggest that the package inserts didn't always discuss this side effect."

I don't even know what you mean here. When discussing the package insert, how can you call citing the package insert itself a "weak source?" Please answer

"To suggest that package inserts didn't always discuss this side effect?" lol, WHAT? I said one of them discussed "this" side effect (side effects that persist after discontination) and the other omitted it

Proscar label: If side effects persist, they USUALLY resolve upon discontinuing 'Proscar'

Propecia label: These side effects went away in men who stopped taking PROPECIA

Clearly, one label indicates side effects can persist after discontinuing the drug, the other label indicates it cannot. This is information Wikipedia readers need to know about. Doctors look at these labels for information on how to treat patients.