Reflux nephropathy: Difference between revisions
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'''Reflux nephropathy''', RN is a term applied when small and scarred kidneys (chronic [[pyelonephritis]], CPN) are associated with [[vesico-ureteric reflux]] (VUR). CPN being the most common cause, there are other causes including analgesic nephropathy and obstructive injury. Scarring is essential in developing RN and occurs almost during the first five years of life. The end results of RN are [[hypertension]], [[proteinuria]], CRF and eventually ESRD, [[Chronic kidney disease|end stage renal disease]]. |
'''Reflux nephropathy''', RN is a term applied when small and scarred kidneys (chronic [[pyelonephritis]], CPN) are associated with [[vesico-ureteric reflux]] (VUR). CPN being the most common cause, there are other causes including analgesic nephropathy and obstructive injury. Scarring is essential in developing RN and occurs almost always during the first five years of life. The end results of RN are [[hypertension]], [[proteinuria]], CRF and eventually ESRD, [[Chronic kidney disease|end stage renal disease]]. |
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The term was introduced in 1973.<ref name="pmid9848795">{{cite journal |author=Dillon MJ, Goonasekera CD |title=Reflux nephropathy |journal=J. Am. Soc. Nephrol. |volume=9 |issue=12 |pages=2377–83 |date=December 1998 |pmid=9848795 |doi= |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9848795}}</ref><ref name="pmid4783715">{{cite journal |author=Bailey RR |title=The relationship of vesico-ureteric reflux to urinary tract infection and chronic pyelonephritis-reflux nephropathy |journal=Clin. Nephrol. |volume=1 |issue=3 |pages=132–41 |year=1973 |pmid=4783715 |doi= |url=}}</ref> |
The term was introduced in 1973.<ref name="pmid9848795">{{cite journal |author=Dillon MJ, Goonasekera CD |title=Reflux nephropathy |journal=J. Am. Soc. Nephrol. |volume=9 |issue=12 |pages=2377–83 |date=December 1998 |pmid=9848795 |doi= |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=9848795}}</ref><ref name="pmid4783715">{{cite journal |author=Bailey RR |title=The relationship of vesico-ureteric reflux to urinary tract infection and chronic pyelonephritis-reflux nephropathy |journal=Clin. Nephrol. |volume=1 |issue=3 |pages=132–41 |year=1973 |pmid=4783715 |doi= |url=}}</ref> |
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Revision as of 20:58, 21 June 2014
| Reflux nephropathy | |
|---|---|
| Specialty | Nephrology  |
Reflux nephropathy, RN is a term applied when small and scarred kidneys (chronic pyelonephritis, CPN) are associated with vesico-ureteric reflux (VUR). CPN being the most common cause, there are other causes including analgesic nephropathy and obstructive injury. Scarring is essential in developing RN and occurs almost always during the first five years of life. The end results of RN are hypertension, proteinuria, CRF and eventually ESRD, end stage renal disease.
The term was introduced in 1973.[1][2]
Diagnosis
It is diagnosed by micturating cystography; scarring can be demonstrated by ultrasound or DMSA.
Incidence/prevalence
There is a genetic predisposition, first-degree relatives have a great increase in the chance of VUR.
The gene frequency is estimated to be 1:600.
The American Academy of Pediatrics recommends that children from 2 to 24 months presenting with a UTI should be investigated for VUR.[citation needed]
Treatment
The aim of treatment is to reduce renal scarring. Those children with grade II or worse should receive low dose prophylactic antibiotics (Nitrofurantoin, trimethoprim, cotrimoxazole, cefalexin in those with CRF). Hypertension should be managed with ACE inhibitor or ARBs. Other treatment modalities include surgery (endoscopic injection of collagen behind the intra-vesical ureter, ureteric re-implantation or lengthening of the submucosal ureteric tunnel) which has its protagonists.
References
- ^ Dillon MJ, Goonasekera CD (December 1998). "Reflux nephropathy". J. Am. Soc. Nephrol. 9 (12): 2377–83. PMID 9848795.
- ^ Bailey RR (1973). "The relationship of vesico-ureteric reflux to urinary tract infection and chronic pyelonephritis-reflux nephropathy". Clin. Nephrol. 1 (3): 132–41. PMID 4783715.