ADH-1: Difference between revisions
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UJHOIJH'''Bold text''' |
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Revision as of 06:35, 1 October 2016
Clinical data | |
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Trade names | Exherin |
Routes of administration | UJHOIJHBold text |
ATC code |
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Identifiers | |
CAS Number | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C22H34N8O6S2 |
Molar mass | 570.69 g/mol g·mol−1 |
3D model (JSmol) | |
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ADH-1 (brand name Exherin) is a small, cyclic pentapeptide vascular-targeting drug.
ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.[1] N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell–cell adhesion and signaling mechanisms;[1] may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.[1]
In a pilot study (phase I trial) at Duke Comprehensive Cancer Center, ADH-1 intravenous pretreatment before chemotherapy in metastatic melanoma completely destroyed tumors in half the patients, normally a very deadly cancer. It is being investigated for advanced extremity melanoma in phase II trials.[2][3]
References
- ^ a b c "ADH-1". NCI Drug Dictionary.
- ^ Yarom N, Stewart D, Malik R, Wells J, Avruch L, Jonker DJ (Feb 1, 2013). "Phase I clinical trial of Exherin (ADH-1) in patients with advanced solid tumors". Curr Clin Pharmacol. 8 (1): 81–88. PMID 22280327.
- ^ Physorg:Drug combination may be effective against deadly melanoma, pilot study shows