AnkB F-Box: Difference between revisions
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'''AnkB F-Box''' is a protein excreted by ''[[Legionella pneumophila]]'' which contains a domain [[F-box protein|F-box]].<ref>Fraser, D.W., Tsai, T,. Orenstein, W., et al. (1977). Legionnaires' disease: description of an epidemic of pneumonia. New England Journal of Medicine. 297:1189–1197.</ref><ref>{{cite web|url=https://legionellacontrol.com/legionella-risk-assessment |title=Legionella Risk Assessment |accessdate= June 22, 2017 | archiveurl=http://www.webcitation.org/6rPZQYd6a |archivedate=June 22, 2017 |deadurl=no}}</ref><ref>McDade, JE., Shepard, C.C., Fraser, D.W., et al., (1977) Legionnaires' Disease — Isolation of a Bacterium and Demonstration of Its Role in Other Respiratory Disease. New England Journal of Medicine. 297: 1197–1203.</ref> |
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'''AnkB F-Box''' is a protein excreted by ''[[Legionella pneumophila]]'' which contains a domain [[F-box protein|F-box]]. |
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F-box proteins are involved in the ubiquitination of proteins targeted for degradation by the proteasome. AnkB F-box is a protein that assembles host cell polyubiquitinated proteins on the cytoplasmatic side of Legionella containing vacuole (LCV).<ref>Christopher T. D. Price, Tasneem Al-Quadan, Marina Santic, Ilan Rosenshine, Yousef Abu Kwaik. Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth. SCIENCE VOL 334 16 DECEMBER 2011</ref> |
F-box proteins are involved in the ubiquitination of proteins targeted for degradation by the proteasome. AnkB F-box is a protein that assembles host cell polyubiquitinated proteins on the cytoplasmatic side of Legionella containing vacuole (LCV).<ref>Christopher T. D. Price, Tasneem Al-Quadan, Marina Santic, Ilan Rosenshine, Yousef Abu Kwaik. Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth. SCIENCE VOL 334 16 DECEMBER 2011</ref> |
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Revision as of 21:32, 22 June 2017
AnkB F-Box is a protein excreted by Legionella pneumophila which contains a domain F-box.[1][2][3]
F-box proteins are involved in the ubiquitination of proteins targeted for degradation by the proteasome. AnkB F-box is a protein that assembles host cell polyubiquitinated proteins on the cytoplasmatic side of Legionella containing vacuole (LCV).[4]
This effector is required for intracellular proliferation within human and amoeba cells and for intrapulmonary Legionella proliferation in mice. The presence of the F-box domain is an example of molecular mimicry of eukaryotic F-box by which Legionella exploits the proteasomal degradation capacity of the host cell for its own sake.[5]
References
- ^ Fraser, D.W., Tsai, T,. Orenstein, W., et al. (1977). Legionnaires' disease: description of an epidemic of pneumonia. New England Journal of Medicine. 297:1189–1197.
- ^ "Legionella Risk Assessment". Archived from the original on June 22, 2017. Retrieved June 22, 2017.
{{cite web}}: Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - ^ McDade, JE., Shepard, C.C., Fraser, D.W., et al., (1977) Legionnaires' Disease — Isolation of a Bacterium and Demonstration of Its Role in Other Respiratory Disease. New England Journal of Medicine. 297: 1197–1203.
- ^ Christopher T. D. Price, Tasneem Al-Quadan, Marina Santic, Ilan Rosenshine, Yousef Abu Kwaik. Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth. SCIENCE VOL 334 16 DECEMBER 2011
- ^ Price C. T., Al-Khodor S., Al-Quadan T., Santic M., Habyarimana F., Kalia A., Kwaik Y. A. (2009). Molecular mimicry by an F-Box Effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa. PLoS Pathog. 5, e1000704. doi: 10.1371/journal.ppat.1000704.
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