Jump to content

Gilles J. Guillemin

Add links
From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Belbernard (talk | contribs) at 14:00, 14 September 2021 (This was "forgotten" when reshuffling the page…). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

File:GillesGuilleminHeadshot.jpg
Professor Gilles Guillemin


Gilles J. Guillemin (born January 1967) is a French-Australian neuroscientist at Macquarie University. He received the Ordre national du Mérite in 2019 in recognition of his work in medical research.[1] He was awarded a Member of the Order of Australia in 2021.[2]

Life

Born in Dijon, France in January 1967, Guillemin moved to Australia in 1997 to pursue post-doctoral studies after he obtained a PhD in Neurovirology from the University of Burgundy.[3]

Notable work

Guillemin has been working in the field of Neuroimmunology since then, with a focus on tryptophan metabolism research.[4]

In 2011, he was involved in the founding of The Motor Neurone Disease (MND) Research Centre at Macquarie University.[5] He was co-director of the centre from 2011 to 2016. As part of his work at the centre, Guillemin and his group study "the involvement of tryptophan in MND" and focus on neuroinflammation and neurotoxicity.[6]

Guillemin has been studying the involvement of tryptophan catabolism (via the kynurenine pathway- KP B) in human neurodegenerative diseases for more than 20 years.[7] Guillemin and his teams have conducted research that demonstrates the importance of the KP in multiple sclerosis, Alzheimer's disease and motor neuron disease, which has diagnostic, prognostic and therapeutic potential.[8] [9] This research has been extended to looking at the chemicals in the brain and their relation to other diseases such as depression, suicide, autism and cancers.[10][11]

Guillemin is part of a research group working on neuroactive (toxic or protective) metabolites derived from tryptophan.[12]

As a result of their research, the team has identified a "new process for the uptake of the neurotoxin quinolinic acid (QUIN) in human neurons that could reduce the impact of major inflammatory diseases".[13] The study built on the results of previous research by Guillemin that demonstrated excessive amounts of QUIN accumulate within the human brain of Alzheimer’s and motor neuron disease (MND) patients.[14]

As an extension of his research on tryptophan and QUIN, Guillemin has also conducted research into Multiple Sclerosis (MS), including a project that discovered the first blood biomarker for MS.[15][16] The result of the project was the identification of a biomarker that can discriminate between the three subtypes of MS with 85-90 percent accuracy, allowing for a more accurate diagnosis of MS in patients.[17][18][19]

Guillemin has been the Editor-in-Chief of The International Journal on Tryptophan Research since 2008.[20]

Pandis

In 2018, Guillemin co-created PANDIS with Catherine Stace.[21] PANDIS is an Australian not-for-profit organisation.[22]

The aim of the organisation is to identify "infectious pathogens in Australian patients with various types of chronic diseases," called PAN for "All" and DIS for "diseases", with a focus on tick-borne diseases.

Motor Neurone Disease BioBank

In 2012, Guillemin, with his colleague Dominic Rowe, co-created the first MND biobank in Australia.[23]

The Motor Neurone Disease (MND) Biobank houses samples that are then available to for use in research projects. One such project was conducted by Guillemin and his team around the analysis of the blood plasma of Amyotrophic lateral sclerosis patients to find ways to improve diagnosis.[24]

Community engagement

Guillemin is involved in "Scientists in Schools" a CSIRO Education program where he shares his experience as a scientist to primary and secondary school students.[25]

Selected publications

  • Opitz, Christiane A.; Litzenburger, Ulrike M.; Sahm, Felix; Ott, Martina; Tritschler, Isabel; Trump, Saskia; Schumacher, Theresa; Jestaedt, Leonie; Schrenk, Dieter; Weller, Michael; Jugold, Manfred; Guillemin, Gilles J.; Miller, Christine L.; Lutz, Christian; Radlwimmer, Bernhard; Lehmann, Irina; von Deimling, Andreas; Wick, Wolfgang; Platten, Michael (2011). "An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor". Nature. 478 (7368). Springer Science and Business Media LLC: 197–203. doi:10.1038/nature10491. ISSN 0028-0836.
  • Guillemin, Gilles J.; Brew, Bruce J. (2003-11-11). "Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification". Journal of Leukocyte Biology. 75 (3). Wiley: 388–397. doi:10.1189/jlb.0303114. ISSN 0741-5400.
  • Braidy, Nady; Guillemin, Gilles J.; Mansour, Hussein; Chan-Ling, Tailoi; Poljak, Anne; Grant, Ross (2011-04-26). Xu, Aimin (ed.). "Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats". PLoS ONE. 6 (4). Public Library of Science (PLoS): e19194. doi:10.1371/journal.pone.0019194. ISSN 1932-6203.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Professional memberships

  • 2014–2020: Elected President of the International Society of Tryptophan research (ISTRY)[26]
  • 2012–2016: Elected President of the International Neurotoxicity Society (NTS)[27]

Awards and honours

  • 2021, June: Awarded a Member of the Order of Australia for "For significant service to science education, to Motor Neurone Disease research, and to sport".[28][29]
  • 2020, March: Awarded a Fellowship of The Royal Society of New South Wales.[30][31]
  • 2019, November: Awarded “Chevalier (Knight) de l’Ordre du Mérite” by the French government in recognition of his work in medical research[32]

Concerns about scientific integrity

Gilles J. Guillemin is the co-author of a number of publications discussed on PubPeer in which image manipulations (duplicated patterns) have been detected. Following the disclosure of fraudulent practice, one paper has already been retracted: Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice, PLoS ONE (2016).

References

  1. ^ "The National Order of Merit | La grande chancellerie". www.legiondhonneur.fr. Retrieved 2020-12-04.
  2. ^ honours.pmc.gov.au https://honours.pmc.gov.au/honours/awards/2009388. Retrieved 2021-07-02. {{cite web}}: Missing or empty |title= (help)
  3. ^ "60 seconds with… Professor Gilles Guillemin | This Week At Macquarie University". Retrieved 2020-08-03.
  4. ^ Administration. "Our projects". Macquarie University. Retrieved 2020-08-03.
  5. ^ Administration. "Macquarie University Centre for Motor Neuron Disease Research". Macquarie University. Retrieved 2020-08-03.
  6. ^ Administration. "Guillemin Group". Macquarie University. Retrieved 2020-12-04.
  7. ^ Adams, Seray; Teo, Charles; McDonald, Kerrie L.; Zinger, Anna; Bustamante, Sonia; Lim, Chai K.; Sundaram, Gayathri; Braidy, Nady; Brew, Bruce J.; Guillemin, Gilles J. (2014). "Involvement of the kynurenine pathway in human glioma pathophysiology". PLOS ONE. 9 (11): e112945. Bibcode:2014PLoSO...9k2945A. doi:10.1371/journal.pone.0112945. ISSN 1932-6203. PMC 4240539. PMID 25415278.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ "Involvement of the kynurenine pathway in MS". MS Research Australia. Retrieved 2020-12-20.
  9. ^ "New mechanisms to reduce impact of neuroinflammatory diseases". UNSW Sydney Medicine. Retrieved 20 December 2020.{{cite web}}: CS1 maint: url-status (link)
  10. ^ 2016 - 3:10PMnews.com.au (2016-08-02). "Breakthrough in suicide prevention". dailytelegraph. Retrieved 2020-12-20.{{cite web}}: CS1 maint: numeric names: authors list (link)
  11. ^ "Inflammation linked to chemical imbalance in schizophrenia". medicalxpress.com. Retrieved 2020-12-20.
  12. ^ Administration. "Guillemin Group". Macquarie University. Retrieved 2020-08-03.
  13. ^ SCIMEX (8 September 2020). "New mechanisms to reduce impact of neuroinflammatory diseases". Scimex. Retrieved 2020-12-20.
  14. ^ "New Mechanisms to Reduce Impact of Neuroinflammatory Diseases". Medianet. Retrieved 2020-12-20.
  15. ^ "Blood biomarker discovery a breakthrough for MS sufferers | Keep It Clever". keepitclever.com.au. Retrieved 2020-12-20.
  16. ^ "MS research breakthrough". MSWA. Retrieved 2020-12-20.
  17. ^ "First blood biomarker discovered for the prognosis of multiple sclerosis: quick, accurate and soon to be available". Retrieved 2020-12-20.
  18. ^ "'Stunning breakthrough' helping to rapidly identify types of MS". www.abc.net.au. 2017-02-03. Retrieved 2020-12-20.
  19. ^ "Blood Test for Multiple Sclerosis May Be Near". HCPLive. Retrieved 2020-12-20.
  20. ^ "International Journal of Tryptophan Research". SAGE Journals. Retrieved 2020-08-03.
  21. ^ "PANDIS (microorganisms & human diseases - Tick-born diseases)". Macquarie University. Retrieved 2020-08-13.
  22. ^ "Personalized Medicine Model Aiming To Improve Diagnosis and Treatment of Chronic Diseases". Diagnostics from Technology Networks. Retrieved 2020-12-20.
  23. ^ "Gilles Guillemin". Macquarie University. Retrieved 2020-08-03.
  24. ^ "Researchers conduct metabolite analysis of ALS patient blood plasma". medicalxpress.com. Retrieved 2020-12-20.
  25. ^ CSIRO. "STEM Professionals in Schools". www.csiro.au. Retrieved 2020-08-03.
  26. ^ "Executive Committee | ISTRY". www.istry.org. Retrieved 2020-08-03.
  27. ^ "Our Officers and Council". www.neurotoxicitysociety.org. Retrieved 2020-12-04.
  28. ^ honours.pmc.gov.au https://honours.pmc.gov.au/honours/awards/2009388. Retrieved 2021-07-02. {{cite web}}: Missing or empty |title= (help)
  29. ^ Naden, Sean (2021-06-13). "Without my students, I wouldn't have got where I am today". The Sydney Morning Herald. Retrieved 2021-07-02.
  30. ^ "Fellows - The Royal Society of NSW". The Royal Society of NSW. Retrieved 2020-08-03.
  31. ^ "Home - The Royal Society of NSW". The Royal Society of NSW. Retrieved 2020-12-20.
  32. ^ "The National Order of Merit | La grande chancellerie". www.legiondhonneur.fr. Retrieved 2020-08-03.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Gilles_J._Guillemin&oldid=1044294059"