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QIAGEN N.V.
Company typePublic
NYSE: QGEN
FWB: QIA
Russell 1000 Component
MDAX Component
IndustryBiotechnology
FoundedNovember 29, 1984; 39 years ago (1984-11-29)
FounderMetin Colpan, Karsten Henco, Jürgen Schumacher
HeadquartersVenlo, Netherlands (corporate)

Hilden

Düsseldorf, Germany (operational)

Maryland, United States(operational),[1][2]
Key people
Thierry Bernard (Chief Executive Officer) , Lawrence A. Rosen[3] (Supervisory Director and Chairman of the Supervisory Board)
RevenueUS $1,870.3 million (2020)[4]
US $386.4 million (2020 adjusted)[5]
Total assetsUS $5,912,530,000 (end of December 2020)[6]
Total equityUS $2,797,839,000 (end of December 2020)[7]
OwnerBlackRock (15.88%)[8]

MFS Investment Management (MFS) (8,87%)[9]

State Street Corp (3,30%)[10]

Goldman Sachs (3.06%)

[11]
Number of employees
about 5,900 (end of June 2021)[12]
Websitewww.qiagen.com

QIAGEN is a German[13] provider of sample and assay technologies for molecular diagnostics, applied testing, academic and pharmaceutical research. Consolidated under the Dutch holding QIAGEN N.V., the company operates more than 35 offices in over 25 countries.[14] QIAGEN's shares are listed at the NYSE (using ticker QGEN) and at the Frankfurt Stock Exchange in the Prime Standard (using ticker QIA). Thierry Bernard is the company's Chief Executive Officer. The main operative headquarters are located in Hilden, Germany.[citation needed]

History

In 1984, QIAGEN was established on November 29 by a team of scientists at the Heinrich Heine University Düsseldorf, Germany. Two years later, QIAGEN launched its first product, a kit for purification of plasmids – small ring-shaped DNA molecules in bacterial cells – cutting the preparation time for plasmids from between two and three days down to two hours.[citation needed] 1996 saw the initial public offering of QIAGEN on the technology-oriented Nasdaq stock exchange, becoming the first German company to do so.[15] 1996 saw the initial public offering on the Frankfurt Stock Exchange in Germany.[citation needed]

Acquisitions

In 2004, QIAGEN acquired key assets of Molecular Staging, Inc. Two years later, QIAGEN established its Asia regional headquarters in Shanghai. In 2007 sales reached US$649.8 million and the number of employees surpassed 2,600. Qiagen acquired Digene for US$1.6 billion, furthering QIAGEN in molecular diagnostics by revenue and diagnostics for disease prevention.[citation needed]

In 2009, QIAGEN began building its Personalized Healthcare business through the acquisition of DxS Ltd, in a deal valued at US$95 million[16] and it acquired SABiosciences Corp. in a deal valued at US$90 million.[17] At the end of 2009 QIAGEN surpassed the US$1 billion revenue mark and had over 3,500 employees. QIAGEN became one of the first companies to release a clinically verified diagnostic test for the detection of H1N1, more commonly known as Swine Flu.[18]

In 2010, QIAGEN acquired ESE GmbH,[19] giving the company access to point of need testing devices for the application of molecular diagnostic tests without laboratory infrastructure. QIAGEN launched the QIAsymphony AS and QIAsymphony RGQ platforms, adding to the company's portfolio for laboratory workflow automation and molecular test full-process automation respectively.[citation needed]

In 2011, QIAGEN acquired Ipsogen S.A. for US$101 million,[20][21] adding to the company's product and IP portfolio in the blood cancer space and developing its position in molecular diagnostics for oncology. QIAGEN also acquired Cellestis Limited for US$374 million,[22] giving the company access to QuantiFERON technology for disease detection and prevention. The company added two new offices in the Asia Pacific region in New Delhi, India and Taipei, Taiwan. The company announced a comprehensive restructuring program to focus on high-growth areas such as personalized medicine and business in emerging markets. The program includes workforce reduction and internal restructuring affecting approximately 10% of the company's 3,900 positions.[23]

In 2013, QIAGEN acquired Ingenuity Systems.[24] QIAGEN also acquired CLC bio, which offers bioinformatics analysis software.[25] In 2015, QIAGEN acquired AdnaGen's circulating tumor cell enrichment technology.[26] Qiagen also acquired Enzymatics enzyme solutions.[27]

In March 2015, a management buyout of QIAGEN Marseille led to the creation of HalioDx.[28] In late 2015 the GeneReader NGS System was launched,[29] and the acquisition of Mo Bio Laboratories was completed.[30]

In 2016, QIAGEN acquired the Danish molecular diagnostics company Exiqon.[31]

In 2017,QIAGEN acquired OmicSoft Corporation, a leading provider of highly curated public datasets.

In 2018, QIAGEN transferred listing to New York Stock Exchange.[32] In April 2018, QIAGEN acquired the Spanish firm STAT-Dx and launched the QIAstat-Dx molecular diagnostics platform. In September 2018 QIAGEN announced a strategic partnership with NeuMoDx to market two fully integrated systems for automated PCR.[33]

In 2019, QIAGEN announced the acquisition of Formulatrix assets to develop a digital PCR platform.[34] An additional acquisition of N-of-One, a privately held U.S. molecular decision support company and pioneer in clinical interpretation services for complex genomic data, to expand its QCI bioinformatics offerings with Real World Insights.[35] In October 2019 QIAGEN entered into an agreement with Illumina granting QIAGEN non-exclusive rights to develop and globally commercialize IVD kits to be used together with Illumina's diagnostic instruments.[36]

Qiagen Acquisitions
  • Qiagen
    • Molecular Staging, Inc. (Acq 2004)
    • Digene (Acq 2007)
    • Corbett Life Science (Acq 2008)
    • DxS Ltd (Acq 2009)
    • SABiosciences Corp. (Acq 2009)
    • ESE GmbH (Acq 2010)
    • Ipsogen S.A. (Acq 2011)
    • Cellestis Limited (Acq 2011)
    • Ingenuity Systems (Acq 2013)
    • CLC bio (Acq 2013)
    • Exiqon (Acq 2016)
    • STAT-Dx (Acq 2018)
    • Formulatrix (Acq 2019)
    • OmicSoft (Acq 2017)
    • N-of-One (Acq 2019)
    • Molecular Staging, Inc. (Acq 2020)
    • NeuMoDx Molecular Inc (Acq 2020)

2020 Thermo Fisher Acquisition Target

On March 3, 2020, Thermo Fisher Scientific announced plans for the acquisition of Qiagen at €39 per share in cash, which valued the transaction at $11.5 billion at the time.[37]

The day after an open letter by hedge fund Davidson Kempner Capital Management, one of Qiagen's largest shareholders, to reject the bid as undervalued,[38] Thermo Fisher raised their tender by 10% to €43 per share, an advance of $1B in value.[39] Davidson Kempner subsequently increased their holdings from 5.1% to 7.3% of Qiagen.[40]

The acquisition offer was terminated on August 13, 2020 having only reached the threshold of 47% of shareholder approval, below the minimum 66.6% required as per agreement. Davidson Kempner was notable as having continued to reject the bid. Because of the lapsed offer, Qiagen was required to reimburse $95 Million to Thermo Fisher in expenses.[41] Within a week of the collapse of the merger, Qiagen's stock rose over 10%.

On August 21, the chairman of the company's supervisory board, Håkan Björklund, stepped down to be immediately replaced by Lawrence Rosen.[42]

Resulting from the failed takeover bid, Qiagen announced it would buy the outstanding 80.1% of shares in NeuMoDx Molecular Inc, it did not already own for about $234 million.[43]

Products

For QIAGEN columns, see column-based nucleic acid purification.

QIAGEN is a worldwide provider of molecular sample and assay technologies. Sample technologies are used to collect samples of tissue, fluids, etc. and stabilize, extract and purify various molecules of interest such as DNA, RNA or proteins from other cellular components. Assay technologies are then used to amplify (multiply) and enrich this small amount of isolated material to make it visible, readable and ready for interpretation. The separation and purification of genetic information is a basic precondition for further application or analysis.[citation needed]

QIAGEN provides molecular technologies offered as kits with open or specific target analytes. According to QIAGEN, the company's current portfolio covers more than 500 products and more than 2,000 patents and licenses.[44]

In 2014, QIAGEN entered into a supply agreement with Trinean for the manufacture of a QIAGEN-branded "micro-volume" spectrophotometer, to be sold under the name "QIAxpert".[45]

Application areas

Until the mid-2000s, QIAGEN was mainly a provider of sample technologies for the academic research market. QIAGEN's current product portfolio includes sample and assay technologies, specific automation solutions, and a bioinformatics analysis portfolio in 4 markets.[citation needed]

Molecular diagnostics

Molecular diagnostics detect the nucleic acids (DNA and RNA) of target diseases or pathogens in samples such as blood or tissue. These procedures can help to detect viruses and bacteria more rapidly and with greater sensitivity and specificity than other methods such as bacterial culture or immunodiagnostics.[46] Molecular diagnostics are also used to analyze individual patient's genomic information to further classify certain diseases and to determine the most appropriate treatment. QIAGEN's portfolio in molecular diagnostics covers various applications which the company divides into three main segments:[47]

• Oncology: The company's portfolio in oncology includes tests for a broad range of clinically relevant biomarkers, particularly in cancer, encompassing companion diagnostics that are marketed in combination with certain drugs, helping to guide treatment decisions. In addition, QIAGEN markets a range of gene panels for research applications in next-generation sequencing, covering dozens of genes associated with various cancers. Furthermore, the company offers technologies for the extraction and enrichment of molecular biomarkers from body fluids, supporting the development of liquid biopsies. Minimally invasive liquid biopsies hold promise to transform the diagnosis and treatment of cancer.[citation needed]

• Modulation of Immune Response: The QuantiFERON-TB Gold In-Tube Test (QFT) is regarded worldwide as the modern standard for detection of latent tuberculosis infection. According to WHO estimates, this condition affects about one-third of the world's population. As up to 10% of people with latent TB infection will develop the active disease in the course of their lives, the identification and treatment of at-risk groups with latent TB is important for sustainable control of this potentially life-threatening infectious disease.[citation needed]

• Infectious Diseases: QIAGEN offers several comprehensive test panels for detection of bacterial and viral pathogens. The portfolio encompasses assays for the detection of individual pathogens such as Influenza, HIV, Hepatitis, and healthcare-associated infections. The company also has a global leadership position in screening for high-risk types of human papillomavirus (HPV), the primary cause of cervical cancer.[citation needed]

Applied testing

Applied Testing is the use of molecular biology/diagnostics in practical, non-clinical applications such as veterinary medicine, forensics, food-quality monitoring and protection against biological hazards. QIAGEN's portfolio includes:[citation needed]

• Food safety: tests for pathogens (such as salmonella, legionella and listeria), allergens, genetically modified organisms as well as food origin and quality.

• Veterinary medicine: tests for pathogens (such as bird flu, for which Qiagen was the first company to offer an approved test) as well as pandemic prevention and monitoring.

• Forensics: tests used to identify victims, prosecute criminals and determine paternity or lineage.

Academic research

The life science research market encompasses all disciplines focusing on living organisms such as humans, animals, plants or bacteria (e.g., biochemistry, biomedicine or genetic engineering). Much of the research is done on a molecular level targeting DNA, RNA and proteins and helps scientists to comprehend basic processes in cells and organisms.[citation needed]

QIAGEN introduced the first kit for purification of plasmids – small ring-shaped DNA molecules in bacterial cells – in 1986, cutting the preparation time for plasmids from between two and three days down to two hours. The company has a global market share exceeding 70% for certain sample preparation technologies.[citation needed]

Pharmaceutical industry

Multinational pharmaceutical companies use molecular sample and assay technologies in all phases of the drug development process, from the fundamental pharmaceutical research stage, through preclinical and clinical studies, to the commercialization and application of new products.[citation needed]

QIAGEN technologies can be used to identify genes that participate in the emergence of diseases, carry out studies on the functions and interactions between genes (or proteins) in entire biological pathways, identify and validate potential biomarkers and identify and evaluate therapeutic target molecules and suitable active agent candidates. QIAGEN's products can also be used in the execution of the clinical studies.[citation needed]

Management

The company's Executive Committee consisted of the following members:[48]

  • Thierry Bernard (Chief Executive Officer)[49]
  • Roland Sackers (Chief Financial Officer)
  • Stephany Foster (Senior Vice President, Head of Human Resources)
  • Antonio Santos (Senior Vice President Global Operations)
  • Thomas Schweins (Senior Vice President Life Science Business Area)
  • Jonathan Sheldon (Senior Vice President, QIAGEN Digital Insights Business Area)
  • Jean-Pascal Viola (Senior Vice President Corporate Business Development)

Structure of the company

QIAGEN has a holding structure. The holding (QIAGEN N.V.) is located in Venlo, The Netherlands. The operative and European headquarters are located in Hilden, Germany. Further American headquarters are located in Maryland United States [citation needed]

References

  1. ^ "Ordering-USA".
  2. ^ https://corporate.qiagen.com/newsroom/press-releases/2020/20200313_QIAstat_BARDA [dead link]
  3. ^ "Supervisory Board". Archived from the original on 2017-07-11.
  4. ^ https://s27.q4cdn.com/986229841/files/doc_presentations/2021/03/v2/20210210-QIAGEN-Q1-2021-INVESTOR-PRESENTATION.pdf [bare URL PDF]
  5. ^ https://s27.q4cdn.com/986229841/files/doc_presentations/2021/03/v2/20210210-QIAGEN-Q1-2021-INVESTOR-PRESENTATION.pdf [bare URL PDF]
  6. ^ "Qiagen N.V. - Investor Relations - at a glance - Key Figures".
  7. ^ "Qiagen N.V. - Investor Relations - at a glance - Key Figures".
  8. ^ "Qiagen N.V. - Investor Relations - Stock Information - Shareholder Structure".
  9. ^ "Qiagen N.V. - Investor Relations - Stock Information - Shareholder Structure".
  10. ^ "Qiagen N.V. - Investor Relations - Stock Information - Shareholder Structure".
  11. ^ "Qiagen N.V. - Investor Relations - Stock Information - Shareholder Structure".
  12. ^ "QIAGEN announces preliminary Q2 2021 results exceeding outlook, updates full-year 2021 outlook for declining COVID-19 test trends and plans new $100 million share repurchase program".
  13. ^ "US-Konkurrent offenbar interessiert: Qiagen erneut als Übernahmekandidat im Fokus".
  14. ^ "About us". corporate.qiagen.com. Archived from the original on 2017-07-11.
  15. ^ Peter A. Brooke, Daniel Penrice (Nov 10, 2009). A Vision for Venture Capital: Realizing the Promise of Global Venture Capital and Private Equity (Winthrop Group). ISBN 978-1584657996.
  16. ^ "Qiagen Acquires UK's DxS in Deal Worth up to $130M". GenomeWeb Daily News. United States: GenomeWeb. 23 September 2009. Archived from the original on 20 March 2011.
  17. ^ Vence, Tracy (16 December 2009). "QIAGEN acquires SABiosciences". BioTechniques. Archived from the original on 20 March 2014.
  18. ^ Chengpei, Zhu; Xiaomin, Zhang (12 September 2009). "Molecular firm Qiagen releases rapid H1N1 test". ChinaDaily. Archived from the original on 20 March 2014.
  19. ^ "QIAGEN Acquires ESE GmbH". News & Events. Bionity. Germany: CHEMIE.DE. 14 January 2010. Archived from the original on 20 March 2014.
  20. ^ "Qiagen Plans to Buy Cancer MDx Firm Ipsogen for $101M". 15 Jun 2011.
  21. ^ "QIAGEN makes proposal to fully acquire Ipsogen". analytica-world.com. Germany: chemie.de. 16 June 2011. Archived from the original on 18 March 2014.
  22. ^ "QIAGEN acquires Cellestis". Medtech News. Pharmaceutical Field. United Kingdom: Health Sector Publishing. 2011. Archived from the original on 20 March 2014.
  23. ^ "QIAGEN (QGEN) Launches Productivity Enhancement Program; 8-10% of Workforce to Be Affected". StreetInsider.com. 28 November 2011. Archived from the original on 30 December 2011.
  24. ^ "QIAGEN acquires Ingenuity Systems". 29 April 2013.
  25. ^ "QIAGEN acquires CLC bio - CLC bio". CLC bio. Retrieved 2016-04-29.
  26. ^ "Qiagen Acquires Novel Circulating Tumor Cell Technology for Liquid Biopsies". GEN News. Mar 17, 2015.
  27. ^ QIAGEN. "QIAGEN - Sample to Insight". www.qiagen.com. Retrieved 2016-04-29.
  28. ^ Staff (17 January 2018). "HalioDx Wins $22.6M in Financing toward Immunoscore Platform, U.S. Expansion". Clinical OMICs. Retrieved 19 January 2018.
  29. ^ QIAGEN. "QIAGEN - Sample to Insight". www.qiagen.com. Retrieved 2016-04-29.
  30. ^ "20160110-preliminary-results". corporate.qiagen.com. Retrieved 2020-04-24.
  31. ^ QIAGEN. "QIAGEN announces successful completion of tender offer for shares in Exiqon". www.qiagen.com. Retrieved 2016-09-07.
  32. ^ "Qiagen To Transfer U.S. Listing Of Global Shares To Nyse". Reuters. 14 February 2018. Retrieved 14 February 2018.
  33. ^ "QIAGEN inks deal with NeuMoDx to offer next-generation systems for molecular diagnostic testing". Reuters. 17 September 2018. Retrieved 16 January 2019.
  34. ^ "Qiagen Talks New Products, Acquisitions for Digital PCR". Reuters. 8 January 2019. Retrieved 16 January 2019.
  35. ^ "Qiagen Acquires N-of-One to Add Molecular Decision Support". Reuters. 7 January 2019. Retrieved 16 January 2019.
  36. ^ "Qiagen Nixes Sequencer Development, Sees New NGS Opportunities With Illumina Deal". GenomeWeb. 8 October 2019. Retrieved 2019-10-10.
  37. ^ Terry, Mark (3 March 2020). "Thermo Fisher Expands Diagnostics Capabilities with $11.5 Billion Takeover of Qiagen". BioSpace.com. Retrieved 22 August 2020.
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  40. ^ Burger, Ludwig (31 July 2020). "Davidson Kempner ups stake in Qiagen to 7.3%". Reuters.com. Retrieved 22 August 2020.
  41. ^ Slabodkin, Greg; Rachal, Maria; Paul Taylor, Nick (13 August 2020). "Thermo Fisher-Qiagen deal falls apart after failing to secure shareholder support". MedTechDive.com. Retrieved 22 August 2020.
  42. ^ "QIAGEN announces new Chairman of Supervisory Board". Qiagen.com. 21 August 2020. Retrieved 22 August 2020.
  43. ^ "Thermo Fisher's Qiagen bid fails after target gets COVID testing boost". Reuters. 13 August 2020.
  44. ^ "Fact Sheet: QIAGEN Strategy". February 2018.
  45. ^ "Trinean, Qiagen Enter into Global Supply Agreement". News - Genomics & Proteomics. Gen. Eng. Biotechnol. News (print). Vol. 34, no. 4. 15 February 2014. p. 18.
  46. ^ DiIulio, Renee (1 March 2006). "Molecular Diagnostics: Challenges and Benefits". Clinical Lab Products. United States. OCLC 60626983. Archived from the original on 20 March 2014.
  47. ^ "Background Molecular Diagnostics". December 2015.
  48. ^ "Executive Committee". QIAGEN.
  49. ^ "Qiagen Partners With Illumina on NGS IVD Kits; CEO Departing; Preliminary Q3 Revenue Growth Lowered". GenomeWeb. 7 October 2019. Retrieved 2019-10-10.
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