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Protein-coding gene in the species Homo sapiens
SARAF is a protein that in humans is encoded by the SARAF gene , formerly known as TMEM66 (transmembrane protein 66).[ 5] [ 6]
SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1 , to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.[ 7]
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