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King-Wai Yau

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King-Wai Yau
photo of King-Wai Yau
King-Wai Yau delivering 2008 Champalimaud Award lecture at ARVO meeting
Born (1948-10-27) October 27, 1948 (age 76)
Guangzhou (Canton), China
CitizenshipUSA
Alma materPrinceton A.B. in physics 1971, Harvard Ph.D in neurobiology 1975
Known formechanisms of sensory transduction in vision and olfaction
Scientific career
FieldsNeuroscience, Biophysics
InstitutionsJohns Hopkins University, University of Texas Medical Branch
Academic advisorsJohn G. Nicholls, Denis A. Baylor, Alan L. Hodgkin
Websiteneuroscience.jhu.edu/KingWaiYau.php

King-Wai Yau (Chinese: 游景威; pinyin: Yóu Jǐngwēi; born October 27, 1948) is a Chinese-born American neuroscientist and Professor of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, Maryland.

Biography

Born in Guangzhou (formerly called Canton), Guangdong, China, he was the sixth of seven children. His family relocated to Hong Kong within months of his birth. His father, a businessman, died when Yau was only five years old.

He attended secondary school in Buddhist Wong Fung Ling College and St. Paul's Co-educational College in Hong Kong, before entering University of Hong Kong Faculty of Medicine to study medicine. Not wanting to be a physician, however, he departed for the United States in 1968 after only one year of medical study. He received an A.B. in physics (University Scholar; Phi Beta Kappa) from Princeton in 1971 and a Ph.D. in neurobiology from Harvard in 1975, completing his doctoral thesis under John G. Nicholls, a former student of Bernard Katz. He did postdoctoral work with Denis A. Baylor at Stanford University, then with Sir Alan L. Hodgkin at University of Cambridge, United Kingdom. Thereafter, he was on the faculty of University of Texas Medical Branch at Galveston (1981–86), rising to Professor of Physiology and Biophysics in 1985. In 1986, he became Professor of Neuroscience and Investigator of Howard Hughes Medical Institute (1986-2004) at Johns Hopkins University School of Medicine, where he has been since.

Scientific contributions

He is known for discoveries on how light and odor are sensed in the eye and the nose, triggering neural signals to be transmitted to the brain. He has greatly elucidated the properties of the light responses and their underlying phototransduction mechanisms in retinal rods and cones,[1] as well as in intrinsically-photosensitive retinal ganglion cells which express the photopigment, melanopsin, to mediate mostly non-image vision such as pupillary light reflex and photoentrainment of the circadian rhythm.[2] He has made similarly important discoveries on olfactory transduction in the receptor neurons of the nasal olfactory epithelium. His work impacts broadly on understanding G-protein signaling at a quantitative level. His investigations on the spontaneous activity of rod and cone pigments have provided a physicochemical explanation for why our vision does not extend into Infrared wavelengths.[3]

He is a Member of the National Academy of Sciences and the National Academy of Medicine, and a Fellow of the American Academy of Arts and Sciences, as well as a Member of Academia Sinica, Taiwan.

Selected honors & awards

Highly-Cited Papers

Articles with over 500 citations according to Google Scholar [1] as of May 6, 2017:

  • 1979 "The membrane current of single rod outer segments",[6] 607 citations
  • 1979 "Responses of retinal rods to single photons",[7] 819 citations
  • 1989 "Cyclic GMP-activated conductance of retinal photoreceptor cells",[8] 590 citations
  • 1990 "Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons",[9] 672 citations
  • 1998 "Identification of ligands for olfactory receptors by functional expression of a receptor library",[10] 534 citations
  • 2002 "Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity",[2] 1579 citations
  • 2003 "Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice",[11] 838 citations
  • 2003 "Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice",[12] 608 citations
  • 2005 "Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN",[13] 798 citations
  • 2006 "Central projections of melanopsin‐expressing retinal ganglion cells in the mouse",[14] 518 citations

References

  1. ^ Yau, KW (1994). "The Friedenwald Lecture: Phototransduction mechanism in retinal rods and cones". Investigative Ophthalmology and Visual Science. 35: 9–32.
  2. ^ a b Hattar, S; Liao HW; Takao M; Berson DM; Yau KW (2002). "Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity". Science. 295 (5557): 1065–1070. Bibcode:2002Sci...295.1065H. doi:10.1126/science.1069609. PMC 2885915. PMID 11834834.
  3. ^ Luo, DG; Yue WWS; Ala-Laurila P; Yau KW (2011). "Activation of visual pigments by light and heat". Science. 332 (6035): 1307–1312. Bibcode:2011Sci...332.1307L. doi:10.1126/science.1200172. PMC 4349410. PMID 21659602.
  4. ^ Baylor, D (1994). "Introduction of King-Wai Yau 1993 Friedenwald Award winner". Investigative Ophthalmology and Visual Science. 35 (1): 6–8. PMID 8300364.
  5. ^ "National Academy of Sciences 2013 Awards".
  6. ^ Baylor DA, Lamb TD, Yau KW (1979). "The membrane current of single rod outer segments". Journal of Physiology. 288: 589–611. PMC 1281446. PMID 112242.
  7. ^ Baylor DA, Lamb TD, Yau KW (1979). "Responses of retinal rods to single photons". Journal of Physiology. 288: 613–634. doi:10.1113/jphysiol.1979.sp012716. PMC 1281447. PMID 112243.
  8. ^ Yau KW, Baylor DA (1989). "Cyclic GMP-activated conductance of retinal photoreceptor cells". Annual Review of Neuroscience. 12: 289–327. doi:10.1146/annurev.neuro.12.1.289. PMID 2467600.
  9. ^ Dhallan RS, Yau KW, Schrader KA, Reed RR (1990). "Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons". Nature. 347 (6289): 184–187. Bibcode:1990Natur.347..184D. doi:10.1038/347184a0. PMID 1697649. S2CID 4362106.
  10. ^ Krautwurst D, Yau KW, Reed RR (1998). "Identification of ligands for olfactory receptors by functional expression of a receptor library". Cell. 95 (7): 917–926. doi:10.1016/S0092-8674(00)81716-X. PMID 9875846. S2CID 15004227.
  11. ^ Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau KW (2003). "Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice". Nature. 424 (6944): 76–81. Bibcode:2003Natur.424...75H. doi:10.1038/nature01761. PMC 2885907. PMID 12808468.
  12. ^ Lucas RJ, Hattar S, Berson DM, Foster RG, Yau KW (2003). "Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice". Science. 299 (5604): 247–249. Bibcode:2003Sci...299..245L. CiteSeerX 10.1.1.1028.8525. doi:10.1126/science.1077293. PMID 12522249. S2CID 46505800.
  13. ^ Dacey DM, Liao HW, Peterson BB, Robinson FR, Smith VC, Pokorny J, Yau KW (2005). "Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN". Nature. 433 (7027): 749–754. Bibcode:2005Natur.433..749D. doi:10.1038/nature03387. PMID 15716953. S2CID 4401722.
  14. ^ Hattar S, Kumar M, Park A, Tong P, Tung J, Yau KW, Berson DM (2006). "Central projections of melanopsin‐expressing retinal ganglion cells in the mouse". Journal of Comparative Neurology. 497 (3): 326–349. doi:10.1002/cne.20970. PMC 2885916. PMID 16736474.
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