This is the current revision of this page, as edited by Kashmiri(talk | contribs) at 13:22, 22 July 2023(MOS violation – not the correct place to add "See also" links, and certainly not en masse.). The present address (URL) is a permanent link to this version.
Revision as of 13:22, 22 July 2023 by Kashmiri(talk | contribs)(MOS violation – not the correct place to add "See also" links, and certainly not en masse.)
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].