CACUL1

CACUL1
Identifiers
Aliases	CACUL1, C10orf46, CAC1, CDK2 associated cullin domain 1
External IDs	MGI: 1926082; HomoloGene: 17821; GeneCards: CACUL1; OMA:CACUL1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.11 Start 118,674,167 bp End 118,755,249 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 D3 Start 60,513,134 bp End 60,569,463 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm epithelium of nasopharynx cardiac muscle tissue of right atrium amniotic fluid gingival epithelium pancreatic epithelial cell endothelial cell myocardium of left ventricle germinal epithelium parietal pleura Top expressed in spermatid seminiferous tubule tail of embryo arcuate nucleus median eminence extensor digitorum longus muscle cingulate gyrus plantaris muscle stroma of bone marrow paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding ubiquitin protein ligase binding ubiquitin protein ligase activity Cellular component cullin-RING ubiquitin ligase complex Biological process cell cycle ubiquitin-dependent protein catabolic process positive regulation of cell population proliferation positive regulation of protein kinase activity G1/S transition of mitotic cell cycle protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143384 78832 Ensembl ENSG00000151893 ENSMUSG00000033417 UniProt Q86Y37 Q8R0X2 RefSeq (mRNA) NM_153810 NM_001172096 NM_001172097 NM_030197 RefSeq (protein) NP_722517 NP_001165567 NP_001165568 NP_084473 Location (UCSC) Chr 10: 118.67 – 118.76 Mb Chr 19: 60.51 – 60.57 Mb PubMed search
Wikidata
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CDK2 associated cullin domain 1 is a protein that in humans is encoded by the CACUL1 gene.

Further reading

• Kong Y, Nan K, Yin Y (2009). "Identification and characterization of CAC1 as a novel CDK2-associated cullin". Cell Cycle. 8 (21): 3552–61. doi:10.4161/cc.8.21.9955. PMID 19829063.
• Kong Y, Bai PS, Sun H, Nan KJ (2012). "Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients". J. Mol. Neurosci. 47 (2): 207–18. doi:10.1007/s12031-012-9717-5. PMID 22415352. S2CID 14719772.
• Kong Y, Bai PS, Sun H, Nan KJ, Chen NZ, Qi XG (2012). "The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer". Int. J. Biochem. Cell Biol. 44 (12): 2321–32. doi:10.1016/j.biocel.2012.08.006. PMID 22903020.
• Moon M, Um SJ, Kim EJ (2012). "CAC1 negatively regulates RARα activity through cooperation with HDAC". Biochem. Biophys. Res. Commun. 427 (1): 41–6. doi:10.1016/j.bbrc.2012.08.142. PMID 22982681.
• Kim J, Park UH, Moon M, Um SJ, Kim EJ (2013). "Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi:10.1016/j.febslet.2012.10.054. PMID 23178685. S2CID 207659623.
• Zheng Q, Zhao LY, Kong Y, Nan KJ, Yao Y, Liao ZJ (2013). "CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line". World J Surg Oncol. 11: 5. doi:10.1186/1477-7819-11-5. PMC 3585504. PMID 23311997.
• Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW (2013). "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells". Biochem. Biophys. Res. Commun. 437 (1): 108–13. doi:10.1016/j.bbrc.2013.06.048. PMID 23806693.
• Kong Y, Ma LQ, Bai PS, Da R, Sun H, Qi XG, Ma JQ, Zhao RM, Chen NZ, Nan KJ (2013). "Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1". Int. J. Biochem. Cell Biol. 45 (11): 2666–78. doi:10.1016/j.biocel.2013.08.015. PMID 24004834.
• Ma HL, Wen XP, Zhang XZ, Wang XL, Zhao DL, Che SM, Dang CX (2015). "miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1)". Cell. Mol. Biol. (Noisy-le-grand). 61 (4): 56–62. PMID 26314198.