FGL1

FGL1
Identifiers
Aliases	FGL1, HFREP1, HP-041, LFIRE-1, LFIRE1, fibrinogen like 1, HPS
External IDs	OMIM: 605776; MGI: 102795; HomoloGene: 37927; GeneCards: FGL1; OMA:FGL1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	17,910,365 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	41,668,193 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; sperm; ; islet of Langerhans; ; buccal mucosa cell; ; testicle; ; pancreatic epithelial cell; ; endometrium; ; placenta; ; left testis;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; motor neuron; ; primary oocyte; ; right kidney; ; proximal tubule; ; secondary oocyte; ; primitive streak; ; Paneth cell; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Orthologs
	2267
	234199
	ENSG00000104760
	ENSMUSG00000031594
	Q08830
	Q71KU9
	NM_201553; NM_004467; NM_147203; NM_201552
	NM_145594
	NP_004458; NP_671736; NP_963846; NP_963847
	NP_663569
	Wikidata
View/Edit Human	View/Edit Mouse

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene.^[5]^[6] Four splice variants exist for this gene.

Function

Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation.^[6]

FGL-1 has also been observed to strongly bind to and activate LAG-3, a regulatory protein expressed on T cells. As LAG-3 has an important role in controlling activated T cells, manipulating FGL-1 binding to T cells has been proposed for both cancer immunotherapy and anti-inflammatory treatments.^[7]

Clinical significance

FGL-1 may play a role in the development of hepatocellular carcinomas.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031594 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M, Hirohashi S (Jul 1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Biochem Biophys Res Commun. 193 (2): 681–7. doi:10.1006/bbrc.1993.1678. PMID 8390249.
^ ^a ^b ^c "Entrez Gene: FGL1 fibrinogen-like 1".
^ Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, et al. (January 2019). "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell. 176 (1–2): 334–347.e12. doi:10.1016/j.cell.2018.11.010. PMC 6365968. PMID 30580966.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hara H, Yoshimura H, Uchida S, et al. (2001). "Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity". Biochim. Biophys. Acta. 1520 (1): 45–53. doi:10.1016/s0167-4781(01)00249-4. PMID 11470158.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Yan J, Yu Y, Wang N, et al. (2004). "LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma". Oncogene. 23 (10): 1939–49. doi:10.1038/sj.onc.1207306. PMID 14981537. S2CID 9243597.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rijken DC, Dirkx SP, Luider TM, Leebeek FW (2006). "Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot". Biochem. Biophys. Res. Commun. 350 (1): 191–4. doi:10.1016/j.bbrc.2006.09.018. PMID 16996032.
Liu Z, Ukomadu C (2008). "Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant". Biochem. Biophys. Res. Commun. 365 (4): 729–34. doi:10.1016/j.bbrc.2007.11.069. PMC 2288651. PMID 18039467.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104760 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8390249-5] Yamamoto T, Gotoh M, Sasaki H, Terada M, Kitajima M, Hirohashi S (Jul 1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Biochem Biophys Res Commun. 193 (2): 681–7. doi:10.1006/bbrc.1993.1678. PMID 8390249.

[entrez-6] "Entrez Gene: FGL1 fibrinogen-like 1".

[pmid30580966-7] Wang J, Sanmamed MF, Datar I, Su TT, Ji L, Sun J, et al. (January 2019). "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell. 176 (1–2): 334–347.e12. doi:10.1016/j.cell.2018.11.010. PMC 6365968. PMID 30580966.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Function

Clinical significance

References

Further reading