Fibrinogen beta chain

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Fibrinogen beta chain
Protein FGB PDB 1fza.png
PDB rendering based on 1fza.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FGB ; HEL-S-78p
External IDs OMIM134830 MGI99501 HomoloGene3772 ChEMBL: 2048 GeneCards: FGB Gene
RNA expression pattern
PBB GE FGB 216238 s at tn.png
PBB GE FGB 204988 at tn.png
More reference expression data
Species Human Mouse
Entrez 2244 110135
Ensembl ENSG00000171564 ENSMUSG00000033831
UniProt P02675 Q8K0E8
RefSeq (mRNA) NM_001184741 NM_181849
RefSeq (protein) NP_001171670 NP_862897
Location (UCSC) Chr 4:
154.56 – 154.57 Mb
Chr 3:
83.04 – 83.05 Mb
PubMed search [1] [2]

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.[1]


Fibrinogen beta chain has been shown to interact with Lipoprotein(a).[2]

See also[edit]


  1. ^ "Entrez Gene: FGB fibrinogen beta chain". 
  2. ^ Klose, R; Fresser F; Kochl S; Parson W; Kapetanopoulos A; Fruchart-Najib J; Baier G; Utermann G (December 2000). "Mapping of a minimal apolipoprotein(a) interaction motif conserved in fibrin(ogen) beta - and gamma -chains". J. Biol. Chem. (UNITED STATES) 275 (49): 38206–12. doi:10.1074/jbc.M003640200. ISSN 0021-9258. PMID 10980194. 

Further reading[edit]