Fibrinogen beta chain

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Protein FGB PDB 1fza.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases FGB, HEL-S-78p, fibrinogen beta chain
External IDs MGI: 99501 HomoloGene: 3772 GeneCards: FGB
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for FGB
Genomic location for FGB
Band 4q31.3 Start 154,562,956 bp[1]
End 154,571,086 bp[1]
RNA expression pattern
PBB GE FGB 204988 at fs.png

PBB GE FGB 216238 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 154.56 – 154.57 Mb Chr 4: 83.04 – 83.05 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.[5]


Fibrinogen beta chain has been shown to interact with Lipoprotein(a).[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171564 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033831 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: FGB fibrinogen beta chain". 
  6. ^ Klose, R; Fresser F; Kochl S; Parson W; Kapetanopoulos A; Fruchart-Najib J; Baier G; Utermann G (December 2000). "Mapping of a minimal apolipoprotein(a) interaction motif conserved in fibrin(ogen) beta - and gamma -chains". J. Biol. Chem. UNITED STATES. 275 (49): 38206–12. doi:10.1074/jbc.M003640200. ISSN 0021-9258. PMID 10980194. 

Further reading[edit]