PDE8A

PDE8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ECM, 3ECN
Identifiers
Aliases	PDE8A, HsT19550, phosphodiesterase 8A
External IDs	OMIM: 602972; MGI: 1277116; HomoloGene: 1957; GeneCards: PDE8A; OMA:PDE8A - orthologs
EC number	3.1.4.53
Gene location (Human)
Chr.	Chromosome 15 (human)
End	85,139,145 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,984,281 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; middle frontal gyrus; ; inferior ganglion of vagus nerve; ; inferior olivary nucleus; ; external globus pallidus; ; subthalamic nucleus; ; mucosa of colon; ; pars reticulata; ; mucosa of sigmoid colon; ; palpebral conjunctiva;
	Top expressed in
	seminiferous tubule; ; cumulus cell; ; spermatocyte; ; lumbar subsegment of spinal cord; ; lacrimal gland; ; spermatid; ; parotid gland; ; calvaria; ; pyloric antrum; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity; kinase binding; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; extracellular exosome;
Biological process	cyclic nucleotide metabolic process; cAMP catabolic process; regulation of transcription, DNA-templated; signal transduction; positive regulation of protein phosphorylation; negative regulation of cell death; positive regulation of ERK1 and ERK2 cascade; cellular response to epidermal growth factor stimulus; negative regulation of hydrogen peroxide-induced cell death; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5151
	18584
	ENSG00000073417
	ENSMUSG00000025584
	O60658
	O88502
NM_001243137; NM_002605; NM_173454; NM_173455; NM_173456;
	NM_173457
	NM_008803
	NP_001230066; NP_002596; NP_775656
	NP_032829
	Wikidata
View/Edit Human	View/Edit Mouse

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.^[5]^[6] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073417 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025584 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–577. doi:10.1006/bbrc.1998.8684. PMID 9618252.
^ "Entrez Gene: PDE8A phosphodiesterase 8A".
^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.

Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA". Annu. Rev. Biochem. 71: 817–846. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043. PMID 12045112.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Glavas NA, Ostenson C, Schaefer JB, et al. (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–6324. Bibcode:2001PNAS...98.6319G. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644.
Wang P, Wu P, Egan RW, Billah MM (2002). "Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution". Gene. 280 (1–2): 183–194. doi:10.1016/S0378-1119(01)00783-1. PMID 11738832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–574. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wu P, Wang P (2005). "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (51): 17634–17639. doi:10.1073/pnas.0407649101. PMC 539753. PMID 15596729.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073417 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025584 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9618252-5] Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–577. doi:10.1006/bbrc.1998.8684. PMID 9618252.

[entrez-6] "Entrez Gene: PDE8A phosphodiesterase 8A".

[pmid21920574-7] Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.

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References

Further reading