Prostaglandin E2
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.006.052 |
Chemical and physical data | |
Formula | C20H32O5 |
Molar mass | 352.465 g/mol g·mol−1 |
In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.
It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour. PGE2 is also sold under the trade name Latanoprost as an opthalamic solution to be used to lower intraocular pressure by increasing outflow of aqueous humour via the uveoscleral route.
The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.
Like other prostaglandins, dinoprostone can be used as an abortifacient.
It works by binding and activating the prostaglandin E2 receptor.
External links
- Dinoprostone - medlineplus.org
- Cervidil - Forest Laboratories, Inc. (the manufacturer of Cervidil).
- Prostin E2 - pfizer.com
- Cervidil/Prostin E2 - RxList.com
- What is Cervidil? - birthingnaturally.net.
- Cervidil/Prostin E2 - drugs.com