Leukotriene B4

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Leukotriene B4
Leukotriene B4.svg
IUPAC name
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid
71160-24-2 YesY
ChEBI CHEBI:15647 YesY
ChemSpider 4444132 YesY
Jmol interactive 3D Image
KEGG C02165 YesY
PubChem 5280492
Molar mass 336.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.[2]

Eicosanoid synthesis. (Leukotrienes at right.)


  1. ^ a b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X. 
  2. ^ http://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013.  Missing or empty |title= (help)