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Prostaglandin E2

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Prostaglandin E2
Clinical data
ATC code
Identifiers
  • 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] hept-5-enoic acid
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.006.052 Edit this at Wikidata
Chemical and physical data
FormulaC20H32O5
Molar mass352.465 g/mol g·mol−1

In medicine, dinoprostone, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour and also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts.

It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.) and Propess (by Ferring Pharmaceuticals), as a vaginal suppository, to prepare the cervix for labour; it is used to induce labour.

The chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid.

Like other prostaglandins, dinoprostone can be used as an abortifacient.

It works by binding and activating the prostaglandin E2 receptor.

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