Talk:Piperidine

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Heterocyclic

There is no mention that piperidine is a heterocyclic compound. I fix it.--84.163.86.13 00:03, 10 October 2006 (UTC)[reply]

Piperidine compounds

No, piperidine is not the same as piperidine compounds. Some editors are obsessed with the following idea:

Piperidine is a structural component of fireant venom.

Piperidine is a structural component of neuroleptics.

ergo: Neuroleptics cause symptoms like fireant venom

etc. See also article on phenothiazine:

Phenothiazine is an insecticide

Phenothiazine compounds are neuroleptics

ergo: Neuroleptics are bugspray and cause anticholinesterase toxicity.

etc. etc.

I have added a few more examples of piperidine toxic compounds to add to this kind of logic. You can check it out.

And: Please don't revert edits without a comment. This is not a looney bin. 70.137.181.232 (talk) 09:24, 21 July 2008 (UTC)[reply]

Added Piperidine alkaloid, which is an insecticide. So, for the records, piperidine compounds fight insects, everywhere. 70.137.181.232 (talk) 00:46, 25 July 2008 (UTC)[reply]

Disgressions

I have just reinstated my recent edits that had been reverted (diff. Here are my detailed reasons:

Quinine is a bad example, it contains quinuclidine, not piperidine
The whole section about ditran has nothing to do with this article
The rest of that section was written in a very unencyclopedic tone and/or had not much to do with piperidine itself
The neuroleptics are not synthesized from piperidine and were clearly in the wrong section
The piperidine structure is so common that it does not make sense to randomly list compounds that have it in their structure

Cacycle (talk) 02:50, 25 July 2008 (UTC)[reply]

The mentioned neuroleptics are not "synthesized from" piperidine, but are piperidine compounds. Checked. 70.137.181.232 (talk) 03:31, 25 July 2008 (UTC)[reply]

I didn't fall over the quinine (didn't add it either). Ditran etc are piperidine compounds, some neuroleptics too. They are not synthesized from piperidine. I agree that the piperidine structure is common. The bulbocapnine was indeed far fetched. So, *sigh*, I agree with your edit. The whole conspiracy theory now down the drain. *sigh*. Can't we at least mention, that anabasine is an insecticide? 70.137.181.232 (talk) 03:02, 25 July 2008 (UTC)[reply]

Sigh* the whole educational effort now ruined *sigh*. Censored! *THEY* don't want us to know the *TRUTH*.

70.137.181.232 (talk) 03:43, 25 July 2008 (UTC)[reply]

I am in favor of the information you added to the piperdine article staying in. The article is quite small compared to many other articles on Wikipedia and i am in favor of the article being expanded to be exhaustive in all compounds containing piperidine. 65.28.227.116 (talk) 04:07, 29 July 2008 (UTC)[reply]

Dispute on piperidine

If piperidine is used as a precursor to commerically significant compounds, then this application merits mention, IMHO. The mere presence of the piperidine-skeleton is more questionable. Otherwise the benzene article would or could indicate it is "in" thousands of compounds, which would be silly. It is very possible that piperidine is a common pharmacophore, a concept that could be explained. In WE-chem, we are constantly dealing with all sorts of editors, often from advocates for some political cause or conspiracy, who cannot suppress an urge to fill these pages with tangential information (e.g. that Socrates drank a tea containing a molecule related to piperidine!), the main virtue of such information being that it is merely true, vs pertinent and notable.--Smokefoot (talk) 17:23, 28 July 2008 (UTC)[reply]

I think there is always some room in the articles about functional groups, heterocycles, and common ring systems, to discuss the properties that are general to the compounds having a given substructure, as well as some specific examples. However, the discussion needs to be focused and avoid too many random-looking examples, or even worse, a selection of not-so-random examples that gives wrong ideas to the reader. One of the statements that was removed during the edit war was that "Many pharmaceutical drugs contain a piperidine ring because the group tends to impart favorable pharmacokinetic properties such as water solubility and bioavailability. Most piperidines induce the liver enzyme CYP2D6, resulting in faster metabolism, such as in many beta-blockers and antiarrhythmics". This kind of information, if true, seems highly relevant, but can we have a reference, please? I did a quick search to see if I could find an article about piperidine as a building block in drug molecules, but I couldn't find it. --Itub (talk) 17:46, 28 July 2008 (UTC)[reply]

That cited part on pharmacokinetics is utter nonsense. That might actually be true for that unnamed class of compounds, but it is clearly not a general feature of the piperidine moiety. You could equally well attribute this to methylene groups. Cacycle (talk) 00:52, 29 July 2008 (UTC)[reply]

The article simply states that piperdine is a structrual component of these drugs which is true: risperidone, raloxifene, minoxidil, thioridazine, haloperidol, droperidol, and mesoridazine. Nowhere is it stateed that the drugs are synthesised from piperidine. Dr CareBear (talk) 14:18, 28 July 2008 (UTC)[reply]

The sentence, as it is there now, suggests that the compound 'contains' piperidine ("Piperidine is found in the following drugs"), which is untrue (and that was true quite a couple of times in the edits). It would be better to say that it is a structural component of the drug. --Dirk Beetstra ^{T C} 14:51, 28 July 2008 (UTC)[reply]