Talk:BRCA1

Anybody...

Anybody think it's kind of funny how the gene that causes breast cancer kind of has the word "BRA" in it? Lol —Preceding unsigned comment added by 99.249.194.215 (talk) 00:09, 25 February 2011 (UTC)

Yes, cancer is hilarious.

Faulty gene

Some text in this article was originally taken from http://ghr.nlm.nih.gov/gene=brca1 (public domain)

I altered this article by adding "faulty" into the sentence "Women and men who inherit a copy of this gene...". This is because it is not the gene which causes an increased risk of cancer, but the presence of a faulty copy of the gene. A faulty copy means the gene's tumour-suppressing abilities cannot be expressed.

It is good that at least a stub is present on the BRCA genes. However, it would be best if both of these were extensively modified. As a first pass, I'd like to see the following: 1. Differential between genetic/familial breast csncers in age of onset (BRCA mutations are far more common in early onset disease) 2. Discussion of associated risks including recurrence on the other side, risks to males carrying mutations, and risks to first degree relatives. 3. Discussion of other cancers at increased risk in BRCA mutaion carriers 4. discussion of differences in clinical presentation of BRCA1 vs BRCA2 carriers 5. Increased prevalence of mutations in Ashkenazi jews This is not my specific field, and it would be great for a specialist to edit these.

adding ProteinBoxBot content

Anyone have any thoughts on how/if we should merge the existing infobox with the one generated using the ProteinBoxBot (shown at right)?

AndrewGNF 22:47, 14 September 2007 (UTC)

I went ahead and replaced the existing protein box with the GNF_Protein_box. The later contained all the information in the former with the exception of information domains and motifs. The the domain and motif information has been included in a new structure section. Cheers. Boghog2 (talk) 18:34, 20 July 2008 (UTC)

Hispanics

JAMA - Hispanics in Northern California have a lot of BRCA1. JFW | T@lk 18:49, 2 January 2008 (UTC)

Well, according to a forward article, those Hispanics are descendents of conversos who fled the Spanish Inquisition. Further, it refers to BCRA1 is a Jewish marker. See http://www.forward.com/articles/how-do-sephardic-jews-figure-into-the-genetic-equa/ Mulp (talk) 04:11, 15 May 2008 (UTC)

Demographic distribution

The prevalence rates in different parts of the world, and among different ethnicities, should be stated on the article. F W Nietzsche (talk) 16:09, 6 January 2009 (UTC)

Interactions

May I suggest that section be turned into a table? E.g. BRCA1 is know to interact with a number of molecules. They are: etc...Calaka (talk) 03:02, 19 September 2009 (UTC)

Some of the interactions have been controversial (BRCA1 interacting with Xist comes to mind). Perhaps going over the list is in order.--Pjlmac (talk) 14:07, 5 October 2009 (UTC)

Yikes, what a mess. I second changing it to a table, and perhaps reviewing it (does each one really need 6 or 7 references?) —Preceding unsigned comment added by 75.73.155.40 (talk) 06:42, 2 December 2009 (UTC)

I have converted the interaction list into a bulleted list and wrapped in a {{div col}} template specifying a fixed column width such that the number of columns dynamically adjusts to the width of the browser window. Does it look OK now? Boghog (talk) 21:17, 2 December 2009 (UTC)

This article would be easier to read and edit if we move this list of interactions (and their many references) to a separate article (BRCA1 interactions ?) ? Rod57 (talk) 14:45, 10 February 2010 (UTC)

I am not sure that spliting out an interaction article is a good idea. For one thing, this creates extra work in creating and maintaining the new article with little if any benefit. One of the justifications for adding lists of known protein-protein interactions to Gene Wiki pages was to reduce the number of orphan articles. BRCA1 is an extreme example that interacts with many other proteins. The interaction section is confined to its own section in the article, therefore I don't see how including this section in the BRCA1 article interferes with editing of the rest of the article. The readability problem may be a problem, especially when viewing with Internet Explorer before version 8 where the list is not displayed in columns. The reference list on the other hand is very long. This could be condensed somewhat by grouping citation and perhaps restricting the citation to review articles. Boghog (talk) 20:28, 10 February 2010 (UTC)

A general discussion of this topic is found at: Portal:Gene_Wiki/Discussion#Split_out_Interactions. Mikael Häggström (talk) 06:29, 15 May 2011 (UTC)

breast cancer

I have a lump behind my nipple which very painful itchy, and leaking substance. I have already had 1 course of antibiotics and it hasnt cleared, could this be just an abyss or breast cancer —Preceding unsigned comment added by Kazzies123 (talk • contribs) 21:37, 2 May 2010 (UTC)

Create BRCA_mutations_overview?

I am contemplating creating something like that for following purposes:

• easy entry/link point for articles such as breast cancer
• gathering epidemiologic and treatment relevant information as much of the available publications deal with all variants or do not distinguish them
• giving pointers to stuff like jewish ashkenazi inteligence theory that would seem somewhat offtopic in either BRCA1/2 articles

Thoughts? Richiez (talk) 14:30, 15 June 2010 (UTC)

User:Mikael Häggström was quicker and created BRCA mutation :) Richiez (talk) 20:27, 18 June 2010 (UTC)

Virus Regulation Help?

Frank Ryan claims in Virolution, p. 142, that endogenous retroviral sequences help in the expression of BRCA-1 (and other human genes). Supposedly demonstrated by a Roy J Britten in 1996. Not sure if this useful in this context, though.