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Vitamin U

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Vitamin U[1]
Names
IUPAC name
(3-amino-3-carboxypropyl)-dimethylsulfanium chloride
Other names
S-Methyl-L-methionine
Vitamin U
Identifiers
3D model (JSmol)
  • InChI=1S/C6H13NO2S.ClH/c1-10(2)4-3-5(7)6(8)9;/h5H,3-4,7H2,1-2H3;1H
  • C[S+](C)CCC(C(=O)O)N.[Cl-]
Properties
C6H14ClNO2S
Molar mass 199.69 g·mol−1
Melting point 134 °C (273 °F)[1] (chloride salt, decomp.)
Hazards
Lethal dose or concentration (LD, LC):
2760 mg/kg (iv, mice, chloride salt)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Vitamin U is a synonym for methylmethionine sulfonium chloride.[2] The term was coined in 1950 by Garnett Cheney for anti-Ulcerogenic[3] factors in raw cabbage juice that sped healing of peptic ulcers (in eleven days versus thirty-seven for placebo).[4][5][6] S-methylmethionine is not the only beneficial compound in these plants.[7] Other research points to fibre preventing ulcers.[8] Glucosinolate is a group of molecules in the Brassicaceae family with gastro- and hepato-protective action.[9] Indoles and iso-thio-cyanates dominate effects of Brassicaceae in this article, because they are products of glucosinolate decomposition.

Gastroenterology

Without myrosinase, bacteria in the rat cecum can hydrolyse glucoraphanin into raphanin.[10] Allyl-iso-thio-cyanate (AITC) increases food transit time in rat colons.[11] Sulforaphane enhances protection and repair of gastric mucosa in vitro.[12] DIM has many molecular targets and dramatic effects against ulcerative colitis and colon cancer in what lives.[13]

Hepatology

While Brassicaceae is a large family of plants containing hepato-protective agents,[14] it does not contain a monopoly on them.[15]

Oncology

I3C promotes cancer cell death in vitro with many molecular targets on breast, prostate, endometrium, colon, and leukocytes.[16] Broccoli sprouts are rich enough in glucoraphanin for experimental results against aflatoxin, a carcinogen.[17] Ulyasov and others found positive results in leukemia with DIM,[18] Glucobrassicin being a precursor of DIM through indole-3-carbinol.

Microbiology

Iso-thio-cyanates are an important factor in the action of Wasabi against Helicobacter Pylori,[19][20][21] and ITC is not a molecule, but a functional group on many different molecules, Sinigrin being a notable precursor of allyl-ITC, and AITC being a larger part of Wasabi than of most other Brassicaceae. Sulforaphane demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.[12]

Contraindications

Brassica species probably cause baby colic in breast-feeding.[22]

References

  1. ^ a b c Merck Index, 12th Edition, 10165
  2. ^ National Center for Biomedical Ontology. "Methylmethionine Sulfonium Chloride".
  3. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15436263, please use {{cite journal}} with |pmid=15436263 instead.
  4. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18104715, please use {{cite journal}} with |pmid=18104715 instead.
  5. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 3010497, please use {{cite journal}} with |pmid=3010497 instead.
  6. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 5839761, please use {{cite journal}} with |pmid=5839761 instead.
  7. ^ http://realfoodforager.com/6-reasons-to-drink-fermented-cabbage-juice/
  8. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20166992, please use {{cite journal}} with |pmid=20166992 instead.
  9. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11506821, please use {{cite journal}} with |pmid=11506821 instead.
  10. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21776467, please use {{cite journal}} with |pmid=21776467 instead.
  11. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21689654, please use {{cite journal}} with |pmid=21689654 instead.
  12. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21548875, please use {{cite journal}} with |pmid=21548875 instead.
  13. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19334074, please use {{cite journal}} with |pmid=19334074 instead.
  14. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16082211, please use {{cite journal}} with |pmid=16082211 instead.
  15. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20128046, please use {{cite journal}} with |pmid=20128046 instead.
  16. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16082211, please use {{cite journal}} with |pmid=16082211 instead.
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  18. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 22514694, please use {{cite journal}} with |pmid=22514694 instead.
  19. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15246236, please use {{cite journal}} with |pmid=15246236 instead.[unreliable medical source?]
  20. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15856408, please use {{cite journal}} with |pmid=15856408 instead.
  21. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12032331, please use {{cite journal}} with |pmid=12032331 instead.
  22. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8537569, please use {{cite journal}} with |pmid=8537569 instead.[unreliable medical source?]

External links

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