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Alice in Wonderland syndrome

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Alice in Wonderland syndrome
Other namesTodd's syndrome,[1] Lilliputian hallucinations, dysmetropsia
Illustration from Lewis Carroll's Alice's Adventures in Wonderland depicting the title character seated hunched over in a tiny room. Alice is positioned awkwardly with her weight supported partially by her left forearm, which rests on the floor and spans nearly half of the room's length. Her head is ducked beneath the low ceiling and her right arm reaches outside, resting on an open window's sill. The folds of Alice's dress occupy much of the remaining free space in the room.
The perception a person can have due to micropsia, a potential symptom of dysmetropsia. From Lewis Carroll's 1865 novel Alice's Adventures in Wonderland
SpecialtyPsychiatry, neurology
SymptomsMicropsia (disoriented perception on objects)
ComplicationsImpaired vision
Usual onsetBefore, during, or after a migraine[2]
DurationEach symptom is separate and will only occur for a 20-to-50-minute period of time.[3]

Alice in Wonderland syndrome (AIWS), also known as Todd's syndrome or dysmetropsia, is a neuropsychological condition that causes a distortion of perception. People may experience distortions in visual perception of objects such as appearing smaller (micropsia) or larger (macropsia), or appearing to be closer (pelopsia) or farther (teleopsia) away than they actually are. Size distortion may occur in other sensory modalities as well.

Alice in Wonderland Syndrome (AIWS) is often associated with migraines, brain tumors, and psychoactive drug use. It can also be the initial symptom of the Epstein–Barr virus (see Epstein-Barr virus-associated lymphoproliferative diseases).[4] AiWS can be caused by abnormal amounts of electrical activity resulting in abnormal blood flow in the parts of the brain that process visual perception and texture.[5]

Anecdotal reports suggest that the symptoms of mononucleosis commonly occur as AiWS in childhood,[6] with many people growing out of it in their teen years. It appears that AiWS is also a common experience at sleep onset and has been known to commonly arise due to a lack of sleep.[citation needed]

Signs and symptoms

AIWS affects the sense of vision, sensation, touch, and hearing, as well as one's own body image.[7] Migraines, nausea, dizziness, and agitation are also commonly associated symptoms with Alice in Wonderland Syndrome.[8] Less frequent symptoms sometimes described in Alice in Wonderland syndrome patients include loss of limb control and dis-coordination, memory loss, lingering touch and sound sensations, and emotional instability.[9]

Visual Distortions

Individuals with AIWS can experience hallucinations or illusions of expansion, reduction or distortion of their own body image, such as microsomatognosia (feeling that their own body or body parts are shrinking), or macrosomatognosia (feeling that their body or body parts are growing taller or larger). These changes in perception are collectively known as metamorphosias, or Lilliputian hallucinations.[9]

People with certain neurological diseases have experienced similar visual hallucinations.[10] These hallucinations are called "Lilliputian", which means that objects appear either smaller or larger than reality.[11]

Patients may experience either micropsia or macropsia. Micropsia is an abnormal visual condition, usually occurring in the context of visual hallucination, in which the affected person sees objects as being smaller than they are in reality.[12] Macropsia is a condition where the individual sees everything larger than it actually is.[13]

One 17-year-old boy described his odd symptoms by the following: "Quite suddenly objects appear small and distant or large and close. I feel as [if] I am getting shorter and smaller 'shrinking' and also the size of persons are not longer than my index finger (a lilliputian proportion). Sometimes I see the blind in the window or the television getting up and down, or my leg or arm is swinging. I may hear the voices of people quite loud and close or faint and far. Occasionally, I experience attacks of migrainous headache associated with eye redness, flashes of lights and a feeling of giddiness. I am always conscious to the intangible changes in myself and my environment".[14]

Although a person's vision is not affected, they will often 'see' objects as the incorrect size, shape or perspective angle. Therefore, people, cars, buildings, houses, animals, trees, environments, etc., look smaller or larger than they should be. Further, depth perception can be altered whereby perceived distances are incorrect. For example, a corridor may appear to be very long, or the ground may appear too close.[9][15]

Hallucinations

Zoopsias is an additional hallucination that is sometimes associated with Alice in Wonderland syndrome. Zoopsias involves hallucinations of either swarms of small animals (e.g. ants and mice etc.), or isolated groups of larger animals (e.g. dogs and elephants etc.).[16] This experience of zoopsias is shared in a variety of conditions, such as delirium tremens.[17]

In addition, some people may, in conjunction with a high fever, experience more intense and overt hallucinations, seeing things that are not there and misinterpreting events and situations.[18]

Hearing and Time Distortions

The person affected by Alice in Wonderland syndrome may also lose a sense of time, a problem similar to the lack of spatial perspective. Time seems to pass very slowly, akin to an LSD experience. The lack of time and space perspective also leads to a distorted sense of velocity. For example, one could be inching along ever so slowly in reality, yet it would seem as if one were sprinting uncontrollably along a moving walkway, leading to severe, overwhelming disorientation.

Sufferers of Alice in Wonderland syndrome can often experience paranoia as a result of disturbances in sound perception. This can include amplification of soft sounds or misinterpretation of common sounds.[19][9]


It has been noted that patients are often reluctant to describe their symptoms due to fear of being labeled with a psychiatric disorder. It is usually easy to rule out psychosis as those with Alice in Wonderland syndrome are typically aware that their hallucinations and distorted perceptions are not 'real', and they have not lost touch with reality.[8] Furthermore, younger patients who frequently experience Alice in Wonderland syndrome may struggle to describe their unusual symptoms, and thus, it is recommended to encourage children to draw their visual illusions during episodes.[9]

It appears that the symptoms of AiWS do not change in severity over the course of the syndrome, and though the symptoms may acutely impact the patient's life, Alice in Wonderland syndrome typically resolves itself within weeks or months.[8] Furthermore, AiWS symptoms occur transiently during the day for short periods of time, with most patients describing their symptoms as lasting anywhere between 10 seconds to 10 minutes. This, combined with the typically short duration of the syndrome, suggests that Alice in Wonderland syndrome typically causes a relatively short-term disruption of normal functioning.

While there currently is no identified genetic locus/loci associated with Alice in Wonderland syndrome, observations suggest that a genetic component does exist. AiWS does appear to be passed on from parent to child, with one case study showcasing a grandmother, mother, son, and daughter all with Alice in Wonderland syndrome. In addition, there is an established hereditary trait of migraines. Examples of environmental influences on the incidence of AiWS include the use of the drug topiramate and potentially the dietary intake of tyramine. Further research is required to establish the genetic and environmental influences on Alice in Wonderland syndrome.[8]

Causes

Complete and partial forms of the Alice in Wonderland syndrome exist in a range of disorders, including epilepsy, intoxicants, infectious states, fevers, and brain lesions.[9] Furthermore, the syndrome is commonly associated with migraines, as well as the use of psychoactive drugs. It can also be the initial symptom of the Epstein–Barr virus (see mononucleosis), and a relationship between the syndrome and mononucleosis has been suggested.[20][6][21][8] Epstein–Barr virus appears to be the most common cause in children, while for adults it is more commonly associated with migraines.[22]

Cerebral hypotheses

AiWS can be caused by abnormal amounts of electrical activity causing abnormal blood flow in the parts of the brain that process visual perception and texture.[5] Nuclear medical techniques using technetium, performed on patients during episodes of Alice in Wonderland syndrome, have demonstrated that AiWS is associated with reduced cerebral perfusion in various cortical regions (frontal, parietal, temporal and occipital), both in combination and in isolation. It has been hypothesized that any condition resulting in a decrease in perfusion of the visual pathways or visual control centers of the brain may be responsible for the syndrome. For example, one study used single photon emission computed tomography to demonstrate reduced cerebral perfusion in the temporal lobe in patients with AiWS.[23] Other theories exist that suggest the syndrome is a result of unspecific cortical dysfunction (e.g. from encephalitis, epilepsy, decreased cerebral perfusion), or reduced blood flow to other areas of the brain.[9][8] Other theories suggest that disordered body image perceptions stem from within the parietal lobe. This has been demonstrated by the production of disturbances of body image through electrical stimulation of the posterior parietal cortex. Other researchers suggest that metamorphopsias may be a result of reduced perfusion of the non-dominant posterior parietal lobe during migraine episodes.[9]

Throughout all the neuroimaging studies, several cortical regions (including the temporoparietal junction within the parietal lobe, and the visual pathway, specifically the occipital lobe) are associated with the development of Alice in Wonderland syndrome symptoms.[1]

Migraines

The role of migraines in Alice in Wonderland syndrome is still not understood, but both vascular and electrical theories have been suggested. For example, visual distortions may be a result of transient, localized ischaemia (an inadequate blood supply to an organ or part of the body) in areas of the visual pathway during migraine attacks. In addition, a spreading wave of depolarization of cells (particularly glial cells) in the cerebral cortex during migraine attacks can eventually activate the trigeminal nerve's regulation of the vascular system. The intense cranial pain during migraines is due to the connection of the trigeminal nerve with the thalamus and thalamic projections onto the sensory cortex. Alice in Wonderland syndrome symptoms can precede, accompany, or replace the typical migraine symptoms.[9]

Diagnosis

Alice in Wonderland syndrome is a disturbance of perception rather than a specific physiological change to the body's systems. The diagnosis can be presumed when other causes have been ruled out and if the patient presents symptoms along with migraines and complains of onset during the day (although it can also occur at night). As there are no established diagnostic criteria for Alice in Wonderland syndrome, there is likely to be a large degree of variability in the diagnostic process and thus it is likely to be poorly diagnosed.[22]

Prognosis

Whatever the cause, the bodily related distortions can recur several times a day and may take some time to abate. Understandably, the person can become alarmed, frightened, and panic-stricken throughout the course of the hallucinations—maybe even hurt themselves or others around them. The symptoms of the syndrome themselves are not harmful and are likely to disappear with time. The outcome is typically not harmful, especially in children, and most patients outgrow these episodes. The long-term prognosis typically depends on the root cause of the syndrome, and it is the underlying condition which must be evaluated and treated. Often, the difficulty lies within the patient's reluctance to describe their symptoms out of fear of being labeled with a psychiatric disorder.

Treatment

At present, Alice in Wonderland syndrome has no standardized treatment plan. Often, treatment methods revolve around migraine prophylaxis, as well as the promotion of a low tyramine diet. Drugs that may be used to prevent migraines include: anticonvulsants, antidepressants, calcium channel blockers, and beta blockers. Other treatments that have been explored include repetitive transcranial magnetic stimulation (rTMS). Further research is required to establish an effective treatment regime.[8] One can also help this by getting close up and looking at things, slowly proceeding to look at things further away.[citation needed]

Epidemiology

The lack of established diagnostic criteria or large-scale epidemiological studies on Alice in Wonderland syndrome means that the exact prevalence of the syndrome is currently unknown. One study on 3,224 adolescents in Japan demonstrated the occurrence of macropsia and micropsia to be 6.5% in boys and 7.3% in girls, suggesting that the symptoms of AiWS may not be so rare.[24]

It appears that the male/female ratio is dependent on the age range being observed. Studies showed that younger males (age range of 5 to 14 years) were 2.69 times more likely to experience AiWS than girls of the same age, while there were no significant differences between students of 13 to 15 years of age. Conversely, female students (16- to 18-year-olds) showed a significantly greater prevalence.[22]

The average age of the start of Alice in Wonderland syndrome is six but it is very normal for some to experience the syndrome from childhood to their late 20s.[8] It is also thought that this syndrome is hereditary because many parents who have AiWS report their children having it as well.[25]

History

The syndrome is sometimes called Todd's syndrome, in reference to an influential description of the condition in 1955 by Dr. John Todd (1914–1987), a British consultant psychiatrist at High Royds Hospital at Menston in West Yorkshire.[26][15][27] Todd discovered that several of his patients experienced severe headaches causing them to see and perceive objects as greatly out of proportion. They had altered sense of time and touch, as well as distorted perceptions of their own body. Although having migraine headaches, none of these patients had brain tumors, damaged eyesight, or mental illness that could have caused similar symptoms. They were also all able to think lucidly and could distinguish hallucinations from reality, however, their perceptions were skewed.[28]

Since Lewis Carroll had been a well-known migraine sufferer with similar symptoms, Todd speculated that Carroll had used his own migraine experiences as a source of inspiration for his famous 1865 novel Alice's Adventures in Wonderland. Carroll's diary reveals that in 1856 he consulted William Bowman, an eminent ophthalmologist, about the visual manifestations of the migraines he regularly experienced.[29] Since Carroll had these migraine symptoms for years before writing Alice’s Adventures, it seemed reasonable[to whom?] that Carroll had used his experiences as inspiration.[citation needed]

Society and Culture

"Gulliver's Travels"

Alice in Wonderland syndrome's symptom of micropsia has also been related to Jonathan Swift's novel Gulliver's Travels. It has been referred to as "Lilliput sight" and "Lilliputian hallucination", a term coined by British physician Raoul Leroy in 1909,[30] based on the small people that inhabited the island of Lilliput in the novel.[31]

"Alice in Wonderland"

Alice in Wonderland syndrome was named after Lewis Carroll's famous 19th-century novel Alice's Adventures in Wonderland. In the story, Alice, the title character, experiences numerous situations similar to those of micropsia and macropsia. The thorough descriptions of metamorphosis clearly described in the novel were the first of their kind to depict the bodily distortions associated with the condition. Speculation has arisen that Carroll may have written the story using his own direct experience with episodes of micropsia resulting from the numerous migraines he was known to suffer from.[32] It has also been suggested that Carroll may have suffered from temporal lobe epilepsy.[33]

See also

References

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  5. ^ a b Feldman, Caroline (April 7, 2008). "A Not So Pleasant Fairy Tale: Investigating Alice in Wonderland Syndrome". Serendip. Serendip Studio, Bryn Mawr College. Archived from the original on November 9, 2008. Retrieved 25 November 2011.
  6. ^ a b Eshel, Lahat (1991). ""Alice in Wonderland" syndrome: a manifestation of infectious mononucleosis in children". Behavioural Neurology. 4 (3): 163–166. doi:10.3233/BEN-1991-4304. PMID 24487499.
  7. ^ Stapinski, Helene (23 June 2014). "I Had Alice in Wonderland Syndrome". The New York Times. Archived from the original on 6 September 2015. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  8. ^ a b c d e f g h O'Toole P, Modestino EJ (June 2017). "Alice in Wonderland Syndrome: A real life version of Lewis Carroll's novel". Brain & Development. 39 (6): 470–474. doi:10.1016/j.braindev.2017.01.004. PMID 28189272.
  9. ^ a b c d e f g h i Farooq O, Fine EJ (December 2017). "Alice in Wonderland Syndrome: A Historical and Medical Review". Pediatric Neurology. 77: 5–11. doi:10.1016/j.pediatrneurol.2017.08.008. PMID 29074056.
  10. ^ "Alice in Wonderland syndrome". Mosby's Dictionary of Medicine, Nursing & Health Professions. Philadelphia: Elsevier Health Sciences. 2009. ISBN 978-0-323-22205-1.
  11. ^ Craighead, W. Edward; Nemeroff, Charles B., eds. (2004). "Hallucinations". The Concise Corsini Encyclopedia of Psychology and Behavioral Science. Hoboken: Wiley. ISBN 978-0-471-22036-7. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  12. ^ "Micropsia". Mosby's Emergency Dictionary. Philadelphia: Elsevier Health Sciences. 1998.
  13. ^ "Macropsia". Collins English Dictionary. London: Collins. 2000. ISBN 978-0-00-752274-3. Archived from the original on 2018-01-07.
  14. ^ Hamed SA (January 2010). "A migraine variant with abdominal colic and Alice in Wonderland syndrome: a case report and review". BMC Neurology. 10: 2. doi:10.1186/1471-2377-10-2. PMC 2817660. PMID 20053267.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  15. ^ a b Lanska JR, Lanska DJ (March 2013). "Alice in Wonderland Syndrome: somesthetic vs visual perceptual disturbance". Neurology. 80 (13): 1262–4. doi:10.1212/WNL.0b013e31828970ae. PMID 23446681.
  16. ^ Ffytche DH (2007-06-07). "Visual hallucinatory syndromes: past, present, and future". Dialogues in Clinical Neuroscience. 9 (2): 173–89. PMC 3181850. PMID 17726916.
  17. ^ Platz WE, Oberlaender FA, Seidel ML (1995). "The phenomenology of perceptual hallucinations in alcohol-induced delirium tremens". Psychopathology. 28 (5): 247–55. doi:10.1159/000284935. PMID 8559948.
  18. ^ "What Is Alice in Wonderland Syndrome?". WebMD. Retrieved 2018-09-06.
  19. ^ Hemsley, Rik (2017-09-13). "Alice in Wonderland Syndrome". aiws.info. Archived from the original on 2017-09-14. Retrieved 2017-09-13. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  20. ^ Cinbis M, Aysun S (May 1992). "Alice in Wonderland syndrome as an initial manifestation of Epstein-Barr virus infection". The British Journal of Ophthalmology. 76 (5): 316. doi:10.1136/bjo.76.5.316. PMC 504267. PMID 1390519.
  21. ^ "Alice in Wonderland syndrome". Taber's Cyclopedic Medical Dictionary. Philadelphia: F. A. Davis Company. 2009. ISBN 978-0-8036-2325-5.
  22. ^ a b c Mastria G, Mancini V, Viganò A, Di Piero V (2016). "Alice in Wonderland Syndrome: A Clinical and Pathophysiological Review". BioMed Research International. 2016: 8243145. doi:10.1155/2016/8243145. PMC 5223006. PMID 28116304.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  23. ^ Kuo YT, Chiu NC, Shen EY, Ho CS, Wu MC (August 1998). "Cerebral perfusion in children with Alice in Wonderland syndrome". Pediatric Neurology. 19 (2): 105–8. doi:10.1016/s0887-8994(98)00037-x. PMID 9744628.
  24. ^ Abe K, Oda N, Araki R, Igata M (July 1989). "Macropsia, micropsia, and episodic illusions in Japanese adolescents". Journal of the American Academy of Child and Adolescent Psychiatry. 28 (4): 493–6. doi:10.1097/00004583-198907000-00004. PMID 2788641.
  25. ^ Weissenstein A, Luchter E, Bittmann MA (2014). "Alice in Wonderland syndrome: A rare neurological manifestation with microscopy in a 6-year-old child". Journal of Pediatric Neurosciences. 9 (3): 303–4. doi:10.4103/1817-1745.147612. PMC 4302569. PMID 25624952.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  26. ^ Todd J (November 1955). "The syndrome of Alice in Wonderland". Canadian Medical Association Journal. 73 (9): 701–4. PMC 1826192. PMID 13304769.
  27. ^ "The Career of Dr John Todd And Drug Addiction Case Studies". Highroydshospital.com. Archived from the original on 2014-06-07. Retrieved 2014-06-04.
  28. ^ Cau C (October 1999). "La sindrome di Alice nel paese delle meraviglie" [The Alice in Wonderland syndrome]. Minerva Medica (in Italian). 90 (10): 397–401. PMID 10767914.
  29. ^ Martin, R. "Through the Looking Glass, Another Look at Migraine" (PDF). Archived (PDF) from the original on 2013-09-21. Retrieved 2013-09-15. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  30. ^ Chand, Prabhat K.; Murthy, Pratima. "Understanding a Strange Phenomenon: Lilliputian Hallucinations". German Journal of Psychiatry. Archived from the original on 2009-01-23. Retrieved 2009-10-25. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  31. ^ "Medical Definition of Lilliputian hallucination". MedicineNet. Retrieved August 16, 2018.
  32. ^ Martin, R. "Through the Looking Glass, Another Look at Migraine" (PDF). Archived (PDF) from the original on 2013-09-21. Retrieved 2013-09-15. {{cite web}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  33. ^ Angier, Natalie (1993-10-12). "In the Temporal Lobes, Seizures and Creativity". The New York Times. ISSN 0362-4331. Archived from the original on 2017-09-13. Retrieved 2017-09-13. {{cite news}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
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