Talk:Quetiapine

Treatment of insomnia

Since the beginning of last year,I've been suffering from severe insomnia,so I need to take a pill of this medicine every single night.This drug was prescripted by my psychiatrist.Lately,I've been really worried about my situation,as I fear that such a long usage period will cause serious side effects,and withdrawing it could possibly worsen my condition or even cause other issues.What do current studies and researchs reveal about that?What are the hazards of taking this medicine for too long or withdrawing it after a period of one or two years?--Ksio.amaral89 (talk) 05:16, 15 March 2012 (UTC)

I'm not sure if this is the right place to ask this question, maybe this section should be removed. Anyway: the possible side effects are by a long shot smaller than the side effects of insomnia. Also, the longer you take it, the easier it will be for you to stop using it. Ask your psychiatrist, he probably knows what he is doing. 189.103.31.150 (talk) 22:35, 14 May 2013 (UTC)

If I were you I would taper Seroquel asap. It is hard to withdraw and has numerous side effects. The use for insomnia is off-label. But the drug is very expensive and that's the reason it's being prescribed for insomnia. Take care.--Justana (talk) 01:55, 8 May 2012 (UTC)

Not that much is know as it has not been well studied. Look at review article on pubmed. Have added evidence to this page. Doc James (talk · contribs · email) (if I write on your page reply on mine) 22:46, 14 May 2013 (UTC)

AstraZeneca's self-editing on Wikipedia, August 2007

Three years before its half-billion dollar fine, AstraZeneca was caught (in August 2007) editing its own Wikipedia page from an IP address originating within the company itself (specifically, AstraZeneca was caught removing warning information about the drug's link to suicidial ideation in minors). This was written up in the entry and on the Talk page, after the scandal received attention from the Times of London, Fox News, etc. Not wanting to be the poster boy for Big Pharma's most egregious trespasses, the company has since become smarter about how it disguises its Wikipedia activity. But I thought it worth mentioning again for the sake of newer editors. Sandover (talk) 10:25, 25 March 2013 (UTC)

Do you think the company is still editing Wikipedia but we have not been able to detect it? Doc James (talk · contribs · email) (if I write on your page reply on mine) 02:38, 26 May 2013 (UTC)

One could, I suppose, ask editors whether they are in the pocket of Big Pharma, but the response would be quite predictable, and quite independent of its own veracity. Or, we could WP:AGF, unless conclusively shown otherwise... DavidLeighEllis (talk) 14:59, 28 July 2013 (UTC)

Citation

The citation for this agent as an adjunct for depression treatment is inappropriate.

the citation for partial agonism at the 5ht1a receptor site is inappropriate. Primary citations should be used when possible: Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine’s antidepressant activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33:2303-12. should replace citation #46

Exclusivity status of Seroquel XR.

Maybe some research about the exclusivity status of Seroquel XR should be done. The "Dosage" section mentions 2017 as the year of expiration of such exclusivity. However, I just got my refill for 150mg tablets, and got a Generic made by Teva, and named Teva Quetiapine XR.

Update: Here are some links about the subject. It seems that AstraZeneca's patent on the XR formula was challenged, and the challenge was upheld in court.

http://www.nortonrosefulbright.com/knowledge/publications/77262/pharma-in-brief-canada-federal-court-dismisses-prohibition-application-for-quetiapine-tablets

http://www.pharmatimes.com/article/12-03-27/Teva_fast_out_of_the_blocks_to_sell_generic_Seroquel.aspx

These links were found with Google using this search expression: "Teva Pharmaceuticals Quetiapine"