User talk:Boghog

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IUPHAR links

Have you managed to make any progress with the IUPHAR links?

regards Chidochangu (talk) 14:56, 28 March 2012 (UTC)[reply]

Hi Chidochangu. The mapping of Wikipedia drug articles to IUPHAR pages is very difficult since Wikipedia does not have any database mechanism (although Wikidata may provide such functionality in the future).

I was able to locate a number of Wikipedia drug articles that were not yet linked to IUPHAR. I have since then added these links. A mapping of Wikipedia drug articles to IUPHAR ligand IDs may be found here (please note that this list does not include mappings that were already in your list).

I have also updated the {{IUPHAR}} template and activated the new links. A mapping of Wikipedia Gene Wiki articles (that link to the IUPHAR database) to Entrez Gene IDs may be found here. Boghog (talk) 15:51, 10 April 2012 (UTC)[reply]

Hi Thank for your help with this list.. I will see what we can do to get the receprocal links set up on IUPHAR-db and will try to send an example to you soon... Chidochangu (talk) —Preceding undated comment added 08:39, 11 April 2012 (UTC).[reply]

Great! Again, I apologize for taking so long but I have been busy in real life and determining the drugbox mappings was non-trivial. Thank you for your help in establishing the reciprocal links. Cheers. Boghog (talk) 18:53, 11 April 2012 (UTC)[reply]

WikiThanks

You are among the top 5% of most active Wikipedians this month! 66.87.2.119 (talk) 16:04, 31 March 2012 (UTC)[reply]

Image request

Hi Boghog! I'm preparing the article "GPCR oligomer" for the german wikipedia in my sandbox. I'd like to ask you whether you could make a sectional drawing of a model of a receptor heterodimer embedded in a membrane. --Hm20 (talk) 10:24, 1 April 2012 (UTC)[reply]

Hi Hm20! I would be happy to help, but I am not exactly sure how to do this. If an experimental structure of a heterodimer were available, this would be very straight forward. Correct me if I am wrong, but I believe no such experimental structures exists. Lacking an experimental structure, do you known if some one has created a model of a heterodimeric structure? Lacking a heterodimer structure, are there any structures (experimental or modeled) of homodimers available (parallel, not anti-parallel)? Boghog (talk) 11:16, 1 April 2012 (UTC)[reply]

Hi, The kappa opioid receptor PDB 4djh is a parallel homodimer in the crystal. It was published in Nature a couple of weeks ago (epub. don't think its in print yet PMID 22437504). Most GPCRs though tend to crystallise as head-to-tail dimers, which is biologically irrelevant. ~~A2-33

Excellent! I take this one. Hm20 (talk) 17:11, 1 April 2012 (UTC)[reply]

Wow, hot off the presses! Thanks A2-33! Hm20, I assume that you want something analogous to the image in TRPV. I will see what I can do. Boghog (talk) 18:08, 1 April 2012 (UTC)[reply]

Initial attempt to the right. How does this look? Boghog (talk) 20:22, 1 April 2012 (UTC)[reply]

Thank you very much, Boghog! I love your drawings. Hm20 (talk) 20:56, 1 April 2012 (UTC)[reply]

I just noticed that the 4djh crystal structure is of a artificial fusion protein between the κ-opioid receptor and lysozyme. In the original graphic, lysozyme appeared to be an intracellular domain which obviously is not right. I have updated the graphic to suppress the display of lysozyme. Sorry about that. Boghog (talk) 06:34, 7 April 2012 (UTC)[reply]

WikiProject Immunology

I see you have edited some of the pages within the scope of immunology. Please have a look at the proposal for a WikiProject Immunology WP:WikiProject Council/Proposals/Immunology and give your opinion (support or oppose). Thank you for your attention. Kinkreet^{~♥moshi moshi♥~} 09:28, 4 April 2012 (UTC)[reply]

Disambiguation link notification for April 5

Hi. When you recently edited GDF6, you added links pointing to the disambiguation pages Epidermis and Noggin (check to confirm | fix with Dab solver). Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

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Resolving KCNMA1

Hi Boghog, I noticed your change to KCNMA1 and realized that there are partially redundant articles on this channel. I worked on this channel for 5 years during my PhD and participated the publication of it crystal structure 7 years later, so it's dear to my heart :) I'd like to propose merging BK channel and KCNMA1, and using 'KCNMA1' as the title. This will reduce redundancy and unify the Gene Wiki article nomenclature with KCNMB1, KCNMB2, etc. Do you have recommendations on how best to proceed? For example, after merging content, should I just add redirects to the old articles? AlexanderPico (talk) 17:49, 11 April 2012 (UTC)[reply]

Hi Alexander. It is great to have some experts like yourself contributing to these Gene Wiki articles! Concerning Calcium-activated potassium channel subunit alpha-1, I have no objection renaming this article to KCNMA1. I am not so sure about merging the BK channel article into KCNMA1 however. The later is a gene/protein specific article while the former is about the alpha tetramer + optional beta subunits. I think it makes some sense to have one parent article that covers both alpha and beta subunits (BK channel) plus separate gene/protein specific articles (KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4). One thing that probably should be moved is the {{Infobox protein family}} (Pfam calcium-activated BK potassium channel alpha subunit) from BK channel to KCNMA1. Thoughts? Boghog (talk) 18:37, 11 April 2012 (UTC)[reply]

I had the same thought initially, but actually the entire BK article is only relevant to the alpha subunit and doesn't say anything substantial about the beta subunits. I was also persuaded by the fact that other articles and templates already provide overview of the complex and list the beta subunits: Calcium-activated_potassium_channel and Template:Ion_channels. AlexanderPico (talk) 19:22, 11 April 2012 (UTC)[reply]

Approaching the issue from the other direction... I'd like to copy the content from BK channel to the KCNMA1 article (since it equally applies), but I'm not sure how best to handle this redundancy and increased maintenance burden. Should I transclude? Should one of the articles just have minimal information and reference the other? AlexanderPico (talk) 20:46, 11 April 2012 (UTC)[reply]

I was feeling bold and went ahead and migrated all the appropriate content from BK channel. I've asked for feedback on the best title for the Gene Wiki article and will proceed by consensus. Then I will likely redirect BK channel to the Gene Wiki article since it will no longer contain unique information. Thanks again for advice. Please feel free to toss a wrench into these plans of mine if they cause you any concern. Cheers, AlexanderPico (talk) 03:40, 12 April 2012 (UTC)[reply]

Disambiguation link notification for April 17

Hi. When you recently edited MSMB, you added a link pointing to the disambiguation page C. albicans (check to confirm | fix with Dab solver). Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

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Image of C. albicans – we live and learn... --ἀνυπόδητος (talk) 11:31, 17 April 2012 (UTC)[reply]

Disambiguation pages can lead to interesting surprises ;-) Cheers. Boghog (talk) 18:00, 17 April 2012 (UTC)[reply]

Thank you for your contributions on the Roundabout (gene) page

Hello Boghog,

I wanted to thank you for your contributions to the Roundabout (gene) page. I am collaborating with a couple others on improving the page as a research-type project, and your editing has certainly helped improve the page, and our project. If you have any other suggestions for the page, be it formatting or information, they would be much appreciated. Again, thank you!

Kaleinonen (talk) 20:38, 19 April 2012 (UTC)[reply]

Hi Kaleinonen. You guys have done an excellent job of expanding the roundabout (gene) article! It looks like it is in pretty good shape. My only suggestion is that there are two sections (guidance of non-neural cells and dyslexia) that only contain one sentence apiece. It would be good if these two sections were expanded somewhat. Again, very nice work. Cheers. Boghog (talk) 20:56, 19 April 2012 (UTC)[reply]

We will certainly work on expanding those two sections, thank you for the suggestion!

Kaleinonen (talk) 13:22, 20 April 2012 (UTC)[reply]

A barnstar for you

		The Modest Barnstar
		Thanks for your recent contributions! 66.87.0.140 (talk) 22:49, 24 April 2012 (UTC)[reply]

^ PDB: 4DJH; Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC (2012). "Structure of the human κ-opioid receptor in complex with JDTic". Nature. doi:10.1038/nature10939. PMID 22437504. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[pmid22437504-1] PDB: 4DJH; Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC (2012). "Structure of the human κ-opioid receptor in complex with JDTic". Nature. doi:10.1038/nature10939. PMID 22437504. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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