(S)-norcoclaurine synthase
Appearance
(S)-norcoclaurine synthase | |||||||||
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Identifiers | |||||||||
EC no. | 4.2.1.78 | ||||||||
CAS no. | 79122-01-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme (S)-norcoclaurine synthase (EC 4.2.1.78) catalyzes the chemical reaction
- 4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (Dopamine) (S)-norcoclaurine + H2O
![](http://upload.wikimedia.org/wikipedia/commons/thumb/2/23/%28S%29-norcoclaurine_synthesis.svg/550px-%28S%29-norcoclaurine_synthesis.svg.png)
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in benzylisoquinoline alkaloid biosynthesis.
References
[edit]- Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555–562. doi:10.1002/jlac.1990199001104.
- Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry. 28 (4): 1083–1086. doi:10.1016/0031-9422(89)80187-6.
- Samanani N, Facchini PJ (2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878–83. doi:10.1074/jbc.M203051200. PMID 12107162.