1,3-Difluoro-2-propanol
Appearance
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IUPAC name
1,3-Difluoro-2-propanol
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.006.561 |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C3H6F2O | |
Molar mass | 96.077 g·mol−1 |
Density | 1.24 g/cm3 (at 25 °C) [1] |
Boiling point | 54–55 °C |
Hazards | |
Flash point | 42 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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1,3-Difluoro-2-propanol is a metabolic poison which disrupts the citric acid cycle and is used as a rodenticide, similar to sodium fluoroacetate. It is the main ingredient (along with 1-chloro-3-fluoro-2-propanol) in the rodenticide product Gliftor which was widely used in the former USSR.[2][3][4]
References
- ^ http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=de&N4=176923%7CALDRICH&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&F=SPEC
- ^ Buklan AI, Kravets AF (1986). "[Gliftor poisoning]". Sud. Med. Ekspert. (in Russian). 29 (1): 55–6. PMID 3961873.
- ^ Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ (1998). "The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote". J. Biochem. Mol. Toxicol. 12 (1): 41–52. doi:10.1002/(SICI)1099-0461(1998)12:1<41::AID-JBT6>3.0.CO;2-P. PMID 9414486.
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: CS1 maint: multiple names: authors list (link) - ^ Menon KI, Feldwick MG, Noakes PS, Mead RJ (2001). "The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate". J. Biochem. Mol. Toxicol. 15 (1): 47–54. doi:10.1002/1099-0461(2001)15:1<47::AID-JBT6>3.0.CO;2-E. PMID 11170315.
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: CS1 maint: multiple names: authors list (link)